A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region
Dimitra Gialama,
Devkee M. Vadukul,
Rebecca J. Thrush
et al.
Abstract:Increasing research efforts focus on exploiting antibodies to inhibit the amyloid formation of neurodegenerative proteins. Nevertheless, it is challenging to discover antibodies that inhibit this process in a specific manner. Using ribosome display, we screened for synthetic single-domain antibodies, i.e., sybodies, of the P1 region of α-synuclein (residues 36−42), a protein that forms amyloid in Parkinson's disease and multiple-system atrophy. Hits were assessed for direct binding to a P1 peptide and the inhi… Show more
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