A Potential Filling Material for Wound Healing and Shaping: Acellular Dermal Matrix Combined with Autologous Dermis

Qu, Siwei; Yi, Jinyao; Chen, Zheng; Zhou, Jianda

doi:10.1007/s00266-019-01516-0

Cited by 6 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acellular dermal matrix is characterized by rapid vascularization, low antigenicity and stable performance. In our previous studies, the acellular dermal matrix was prepared in granular form for injection lling and we found that it was characterized by high stability, low in ammatory response, and low absorption rate (7). In this study, acellular dermal matrix particles prepared were selected for further study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human adipose-derived stem cells can optimize the filling material in rats

Wang

et al. 2023

BME

Self Cite

View full text Add to dashboard Cite

BACKGROUND: Human adipose-derived stem cells have been identified as a promising candidate for cell-assisted therapy to improve graft survival. OBJECTIVE: To objective of the study was to add human adipose-derived stem cells into filling materials. METHODS: The filling materials were prepared and divided into 6 groups: fat particles with phosphate buffer saline or human adipose-derived stem cells; acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells; mixture of fat particles and acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells. The survival rate, vascular density and histological at 2, 6 and 12 weeks were investigated. RESULTS: Human adipose-derived stem cells significantly improved survival rate in each group at 6 and 12 weeks, and it significantly increased the vascular density in the fat particles and porcine acellular dermal matrix combined group and porcine acellular dermal matrix group at three time points, but human adipose-derived stem cells did not have a significant effect in the fat particles group. CONCLUSION: Human adipose-derived stem cells as assisted cells added into filling material can improve survival rate and vascular density in rats.

show abstract

Section: Discussionmentioning

confidence: 99%

“…ADM is widely used in the elds of burn, plastic surgery, surgery and wound repair (4)(5)(6). In our previous studies, we made cellular dermal matrix particles and explored acellular dermal matrix as a potential injectable ller material (7).…”

Section: Introductionmentioning

confidence: 99%

Human adipose-derived stem cells can optimize the filling material in rats

Wang

et al. 2023

BME

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nevertheless, adequately designed randomized control studies with long‐term monitoring are deserved in the next furure 29,30,47 . Moreover, further studies use in different body areas should be performed to stimulate and/or orientate the production of hADMs by skin Tissue Establishments.…”

Section: Discussionmentioning

confidence: 99%

“…These products can be easily employed both in the surgical room and in the ambulatory setting. In the next future, surgeons dealing with reconstructive surgery and physicians managing patients with deep/complicated wounds should be more confident in using hADMs grafts, can be regarded as a precious resource of especially in territories where skin tissue banks can easily deliver free‐dried tissue, storable at room temperature and ready‐to‐use 26,47 …”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, adequately designed randomized control studies with long-term monitoring are deserved in the next furure. 29,30,47 Moreover, further studies use in different body areas should be F I G U R E 8 A 71-year-old patient with lipodermatosclerosis and venous insufficiency presented with a post-traumatic deep wound at malleolar site. After surgical and enzymatic debridment A, a triple-layer grafting was realized.…”

Section: Burnsmentioning

confidence: 99%

See 1 more Smart Citation

The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Tognetti

Pianigiani

Ierardi

et al. 2021

Dermatologic Therapy

View full text Add to dashboard Cite

Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head-and-neck, oral cavity, legs) are particularly challenging and can often be delayed due to local and systemic factors. In case of deep wounds and/or hard-to-heal wounds, grafting of dermal acellular matrices (ADM) is often needed. Though a great variety of synthetic and semisynthetic dermal and skin equivalents are available, viable human dermis, is still considered the most physiological alternative to replace the loss of autologous dermis, by acting as a physiological scaffold that add structural support to soft tissues. To date, human ADMs (hADMs) have been employed in the reconstruction of skin defects affecting almost all body sites, ranging from visceral sites to the skin and subcutaneous tissues. This review aims to investigate the use of hADM at different body sites and their peculiar advantages. A literature search was using the search terms "acellular dermal matrices", "dermal regeneration", "advances wound healing", "human acellular dermal matrices surgery". A total of 50 out of 150 papers was included. Based on the current body if evidence, hADMs appear to bring several advantages, such as: protection of deep structures (eg, tendons, bones, cartilage and nerves); stimulation of a functional new dermis (rather than a scar); reduction of wound closure time; control of pain and exudate. Finally, hADMs may represent the best treatment option for hard-to-heal wound not only in terms of efficacy and patient satisfaction bout also in terms of sanitary costs, especially across Europe, where hADMs cannot be commercialized as medical devices.

show abstract