A potential role for adrenal androgens in postpartum psychiatric distress

Marrs, Chandler; Ferraro, Douglas P.; Cross, Chad L.; Rogers, Sherise C.

doi:10.1016/j.ejogrb.2008.12.008

Cited by 12 publications

(9 citation statements)

References 3 publications

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“…One classic study found that estrogen levels were lower 4-6 weeks and 0-2 weeks before delivery in women with depressive symptoms (10), whereas Buckwalter et al (11) found progesterone, not estradiol, to be associated with depressive scores. In addition, women with lower late pregnancy testosterone concentrations (-60 pg/mL), experienced more postpartum psychiatric disturbances compared with those with elevated postpartum DHEA-S concentrations ()2500 pg/mL) (13). The study found that significant psychiatric distress exhibited lower late pregnancy testosterone, followed by elevated postpartum DHEA-S concentrations.…”

Section: Introductionmentioning

confidence: 76%

No impact of gonadal steroid levels on the association between C-reactive protein and prepartum depression scores

Scrandis¹,

Siddiqi²,

Postolache³

2010

International Journal on Disability and Human Development

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Background: Gonadal steroids interact with immune function and mood regulation: their levels during pregnancy, and their subsequent drop during the postpartum period, have been hypothesized to contribute to prepartum depressive symptoms. The objective was to estimate if a previously reported interaction between C-reactive protein (CRP) and peripartum depressive symptoms is at least partially mediated or modified by levels of gonadal steroids. The study group comprised 29 women at high-risk for developing postpartum depression. Methods: We conducted a preliminary longitudinal study with 29 women who were at high-risk of developing depressive symptoms during pregnancy and after delivery. Typical and atypical depression scores were measured at 35-38 weeks' gestation, 1-5 days postpartum, and 5-6 weeks postpartum. Estradiol, progesterone, testosterone, CRP, and interleukin-6 were measured at each time point. Results: Prepartum CRP and atypical depression scores remained significantly correlated after adjusting for gonadal steroid levels. Conclusions:In future larger studies that address the role of potential inflammatory markers in prepartum depression, adjustment for gonadal steroids might not be necessary. However, future studies investigating interactions between prolactin, HPA axis and gonadal steroids and molecular and cellular mediators of inflammation, and their downstream effects could lead to new understanding and therapeutic targeting of peripartum depression.

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Section: Introductionmentioning

confidence: 76%

No impact of gonadal steroid levels on the association between C-reactive protein and prepartum depression scores

Scrandis¹,

Siddiqi²,

Postolache³

2010

International Journal on Disability and Human Development

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“…This study, however, had only 19 participants who were assessed during the last 2 months of pregnancy and again within 2 months following delivery, not focusing on the immediate postpartum period neither using a continuous follow-up [24]. Finally, a recent study showed that hormone concentrations between symptomatic and asymptomatic participants demonstrated no significant patterns for progesterone, estrone, estradiol or estriol but showed an association with testosterone and DHEAS [25,26]. Following childbirth, progesterone levels decline abruptly and this has been implicated in postpartum mood changes.…”

Section: Discussionmentioning

confidence: 99%

Reproductive hormones and postpartum mood disturbances in Greek women

Chatzicharalampous¹,

Rizos²,

Pliatsika³

et al. 2010

Gynecological Endocrinology

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“…In a smaller study of healthy women with no prior psychopathology, n=27, prenatal DHEA-S correlated with prenatal paranoia and psychoticism and postpartum DHEA-S correlated with postpartum anxiety symptoms, paranoia, and somatization. The scale used was the Symptoms Checklist 90-R [66]. These limited results seem more consistent with what one would theoretically expect based on evidence from the inhibitory NASs, and opposite to those found for DHEA -so clearly more research is warranted.…”

Section: Dehydroepiandrosterone (Dhea)mentioning

confidence: 61%

Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature

McEvoy

Payne

Osborne

2018

Curr Psychiatry Rep

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The bulk of the evidence on neuroactive steroids in perinatal depression concerns allopregnanolone. Recent studies have been mixed, with some studies finding a direct correlation between lower levels of allopregnanolone and increased depressive symptoms but other studies finding no relationship. Evidence concerning other neuroactive steroids and perinatal depression is sparse. Additional research is needed with larger sample sizes and better characterization across the perinatal period (rather than cross-sectionally). Because some studies point to a lag between neuroactive steroid dysregulation and subsequent symptoms, future research should consider interactions with other aspects of neuroactive steroid physiology, such as synthetic enzymes or receptor plasticity.

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A potential role for adrenal androgens in postpartum psychiatric distress

Cited by 12 publications

References 3 publications

No impact of gonadal steroid levels on the association between C-reactive protein and prepartum depression scores

No impact of gonadal steroid levels on the association between C-reactive protein and prepartum depression scores

Reproductive hormones and postpartum mood disturbances in Greek women

Neuroactive Steroids and Perinatal Depression: a Review of Recent Literature

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