2020
DOI: 10.3389/fendo.2020.608248
|View full text |Cite
|
Sign up to set email alerts
|

A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia

Abstract: Obesity and obesity-related diseases are major public health concerns that have been exponentially growing in the last decades. Bariatric surgery is an effective long-term treatment to achieve weight loss and obesity comorbidity remission. Post-bariatric hypoglycemia (PBH) is a late complication of bariatric surgery most commonly reported after Roux-en-Y gastric bypass (RYGB). PBH is the end result of postprandial hyperinsulinemia but additional endocrine mechanisms involved are still under debate. Our aim was… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
13
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 14 publications
(15 citation statements)
references
References 47 publications
2
13
0
Order By: Relevance
“…Against our hypothesis and indications from previous work using provocative tests [ 46 ], counter-regulatory responses to hypoglycaemia did not differ significantly between the PBH and the RYGB control group. Although attenuated counter-regulation may predispose to PBH, these response patterns may be rather characteristic of the altered post-bariatric surgery physiology (sustained weight loss and lower nadir glucose levels) rather than a root cause of PBH.…”
Section: Discussionsupporting
confidence: 80%
“…Against our hypothesis and indications from previous work using provocative tests [ 46 ], counter-regulatory responses to hypoglycaemia did not differ significantly between the PBH and the RYGB control group. Although attenuated counter-regulation may predispose to PBH, these response patterns may be rather characteristic of the altered post-bariatric surgery physiology (sustained weight loss and lower nadir glucose levels) rather than a root cause of PBH.…”
Section: Discussionsupporting
confidence: 80%
“…Previous papers on “variability” have used various indices to evaluate their variability. SD has been used to evaluate the glycemic, blood pressure, and fasting TG variability ( 19 , 20 , 32 , 33 ) ( 34 , 35 ); the Adj-SD has also been used to evaluate the glycemic and fasting TG variability with adjusting for the number of measurements ( 19 , 21 , 22 , 36 ); and the MMD has been used to evaluate the glycemic and blood pressure variability ( 23 , 24 , 37 , 38 ). Our study suggested that the SD and Adj-SD might be more reliable than MMD, but MMD is calculated more easily than the other two.…”
Section: Discussionmentioning
confidence: 99%
“…Three indices of postprandial TG variability were calculated; the standard deviation (SD), SD adjusted (Adj-SD) for the number of measurements, and maximum minus minimum difference (MMD) of postprandial TG during the first three years of follow-up ( 19 22 ) ( 23 , 24 ). To minimize the effect of different numbers of TG measurements on the calculated values, the Adj-SD was defined according to the following formula: Adj − SD = SD/√[ n /( n − 1)].…”
Section: Methodsmentioning
confidence: 99%
“…A total number of participants accounted for 527 patients, including 42 patients who dropped out from 5.5 to 7.5 years follow-up (Figure 1). Three indices of postprandial TG variability were calculated, including standard deviation (SD), SD adjusted (Adj-SD) for the number of measurements, and maximum minus minimum difference (MMD) of postprandial TG during the rst 3-year follow up (19) (20) (21) (22) (23) (24). To minimize any effect of different numbers of TG measurements on the calculated values, an Adj-SD was de ned according to the formula: Adj-SD = SD/√[n/(n−1)].…”
Section: Study Design and Participantsmentioning
confidence: 99%