A potential role of mechano-gated potassium channels in meningioma-related seizures

Bogdanović, Ivan; Opačić, Miloš; Baščarević, Vladimir; Raičević, Savo; Ilić, Rosanda; Grujičić, Danica; Spasojević, Ivan; Ristić, Aleksandar J.

doi:10.1016/j.heliyon.2023.e20761

Cited by 1 publication

(1 citation statement)

References 24 publications

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“… 128 The cortical TREK‐1 level in patients with meningioma‐associated epilepsy was lower than that in meningioma patients without seizures, while the cortical TRAAK level in patients without seizures after meningioma resection was higher than that in patients still with seizures after operation, indicating a potential association among an aberrant mechanical condition given the tumor, the level changes of MSCs, and the seizures, which is deserved to explore in future. 129 …”

Section: The Mscs Respond To Stiffness Changes In Neurodegenerative D...mentioning

confidence: 99%

Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

Li,

Zhao,

Tian

et al. 2024

CNS Neurosci Ther

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BackgroundAs physical signals, mechanical cues regulate the neural cells in the brain. The mechanosensitive channels (MSCs) perceive the mechanical cues and transduce them by permeating specific ions or molecules across the plasma membrane, and finally trigger a series of intracellular bioelectrical and biochemical signals. Emerging evidence supports that wide‐distributed, high‐expressed MSCs like Piezo1 play important roles in several neurophysiological processes and neurological disorders.AimsTo systematically conclude the functions of MSCs in the brain and provide a novel mechanobiological perspective for brain diseases.MethodWe summarized the mechanical cues and MSCs detected in the brain and the research progress on the functional roles of MSCs in physiological conditions. We then concluded the pathological activation and downstream pathways triggered by MSCs in two categories of brain diseases, neurodegenerative diseases and place‐occupying damages. Finally, we outlined the methods for manipulating MSCs and discussed their medical potential with some crucial outstanding issues.ResultsThe MSCs present underlying common mechanisms in different brain diseases by acting as the “transportation hubs” to transduce the distinct signal patterns: the upstream mechanical cues and the downstream intracellular pathways. Manipulating the MSCs is feasible to alter the complicated downstream processes, providing them promising targets for clinical treatment.ConclusionsRecent research on MSCs provides a novel insight into brain diseases. The common mechanisms mediated by MSCs inspire a wide range of therapeutic potentials targeted on MSCs in different brain diseases.

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Section: The Mscs Respond To Stiffness Changes In Neurodegenerative D...mentioning

confidence: 99%

Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

Li,

Zhao,

Tian

et al. 2024

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

A potential role of mechano-gated potassium channels in meningioma-related seizures

Cited by 1 publication

References 24 publications

Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

Mechanobiological insight into brain diseases based on mechanosensitive channels: Common mechanisms and clinical potential

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