A potential role of mesenchymal stem cells derived from human umbilical cord blood in ameliorating psoriasis-like skin lesion in the rats

Attia, Sally S.; Rafla, M; El-Nefiawy, Nagwa; Hamid, Hemmat; Amin, Mariam Asaad; Fetouh, Marwa A.

doi:10.5603/fm.a2021.0076

Cited by 10 publications

(5 citation statements)

References 33 publications

(48 reference statements)

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“…Electron microscopy showed that the epidermis of psoriasis cured by hUC-MSCs had uniform thickness, complete epidermis layers, clear boundary between the dermis and the epidermis, complete basement membrane, and no gap between tightly connected basal layer cells and basement membrane. Moreover, hUC-MSCs treatment could also reduce the expression of CD4, CD8 and CD31 in T cells ( 18 ). hUC-MSCs can significantly reduce the severity and development of psoriasis, inhibit the infiltration of immune cells into the skin, and downregulate the expression of various proinflammatory cytokines and chemokines, including first inhibiting neutrophil function and then downregulating the production of type I interferon in plasmacytoid dendritic cells ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Wang

et al. 2022

Front. Immunol.

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ObjectiveTo investigate the efficacy of indirubin combined with human umbilical cord mesenchymal stem cells (hUC-MSCs) in the treatment of psoriatic lesions in BALB/c mice and to explore the related mechanism of indirubin in the treatment of psoriasis.MethodsA BALB/c mouse psoriasis model induced by imiquimod was established and randomly divided into the control group, model group, indirubin group, hUC-MSCs group, and indirubin combined with hUC-MSCs group. Psoriasis area and severity index (PASI) score was used to observe skin lesion changes in the psoriasis-like mouse model. The epidermal scale, the degree of keratinization, and the infiltration of inflammatory cells were observed by hematoxylin eosin (HE) staining. The concentrations of TNF-α, IFN-γ, IL-17A, and IL-23 in serum of mice were measured using enzyme-linked immunosorbent assay (ELISA).ResultsThe PASI integral trend chart indicates that hUC-MSCs and indirubin and the combination of drugs could relieve the appearance of skin lesions and accelerate the recovery of skin lesions. The indirubin group had the best effect in improving the scale of skin lesions. HE staining showed that the number of parakeratosis cells in the three treatment groups was significantly reduced, the degree of erythrocyte extravasation dermis hyperplasia and inflammatory cell infiltration was significantly lower than that in the model group, and the skin thickness and spleen index of the combined treatment group exhibited the most noticeable improvement. ELISA showed that the concentrations of TNF-α, IFN-γ, IL-17A, and IL-23 in serum of mice in the hUC-MSCs treatment group, indirubin group, and combined administration group were all decreased compared with those in the model group, and the concentrations of IFN-γ, IL-17A, and IL-23 could be decreased significantly in the indirubin group.ConclusionsBoth hUC-MSCs and indirubin can effectively reduce psoriasis-like lesions in BALB/c mice, and the combined administration of these drugs has the best effect.

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Section: Discussionmentioning

confidence: 99%

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Wang

et al. 2022

Front. Immunol.

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“…A study testing a treatment with umbilical cord-derived MSCs (UC-MSCs) resulted in comparison with the conventional treatments (betamethasone cream) on imiquimod-induced psoriasis-like skin lesion in adult male albino rat model. MSCs showed efficacy in reducing the severity of the disease, demonstrating that the cells had anti-inflammatory and immunomodulatory effects by inhibiting the clinical manifestation [55].…”

Section: Application Of Mscs In Autoimmune Skin Diseasesmentioning

confidence: 99%

“…Therefore, keratinocytes can trigger psoriasis and actively participate in a complex environment coordinated by cytokines [54]. The treatments depend on the severity of the disease, from topical agents and phototherapy to the usual immunosuppressant drugs [55]. However, these therapies are expensive and are related to adverse reactions, and therefore, there is a need to discover a more effective and safer treatment.…”

Section: Application Of Mscs In Autoimmune Skin Diseasesmentioning

confidence: 99%

Application of Cell-Based Therapies in Veterinary Dermatology

Mesquita¹,

Lopes²,

Sousa³

et al. 2023

Wound Healing - Recent Advances and Future Opportunities

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Stem cells have been extensively studied in the field of veterinary medicine due to their unique characteristics. The last are undifferentiated cells with self-renewal, anti-inflammatory, and immunomodulatory capacity. Mesenchymal stem cells (MSCs) are widely used due to its simple isolation and expansion, being collected from different sources such as adipose tissue, bone marrow, peripheral blood, and umbilical cord. For that reason, MSCs have been studied and used as innovative therapies in the treatment of several diseases, such as tendinitis, bone regeneration, osteoarthritis, neuromuscular diseases, heart diseases, respiratory diseases, kidney disorders, ophthalmology, oncology, and dermatology. Concerning dermatological problems, the number of skin diseases in animals has been increasing in recent years. Skin diseases may be related to genetic conditions, external aggressions, or immunological disorders. Many of these skin pathologies are chronic, reason why the animals are subjected to long-term therapies, which can have deleterious side effects. This review aims to highlight the importance of cell-based therapies, using MSCs from different origins and their secretome, in the field of veterinary dermatology and in immune-mediated diseases such as atopic dermatitis, furunculosis, anal vasculitis, and scar tissue regeneration. These approaches should be further explored, as they have revealed promising results in the search for novel therapies.

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“…With advancing technology for administering MSCs, the application of MSCs has emerged as a promising strategy for the treatment of skin inflammatory disease due to their capability of regeneration, immunomodulation, and differentiation ( 45 ). Recent research found that MSCs have efficacy in the reduction of disease severity and epidermal thickness, arranging layers of epidermal layers, and keeping an intact basement membrane through its powerful capability of immunoregulation ( 46 , 47 ). MSCs can be harvested from different tissues as mentioned before, whereas from different resources MSCs may have various therapeutic effects on skin inflammatory diseases.…”

Section: The Effects Of Mscs From Different Resources On Ad and Psori...mentioning

confidence: 99%

Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis

Yang

Xiao

et al. 2023

Front. Immunol.

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Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and psoriasis has been based on the inhibition, not regulation, of the abnormal inflammatory response, which can induce a number of side effects and drug resistance in long-term treatment. Mesenchymal stem/stromal cells (MSCs) and their derivatives have been widely used in immune diseases based on their regeneration, differentiation, and immunomodulation with few adverse effects, which makes MSCs a promising treatment for chronic skin inflammatory diseases. As a result, in this review, we aim to systematically discuss the therapeutic effects of various resources of MSCs, the application of preconditioning MSCs and engineering extracellular vesicles (EVs) in AD and psoriasis, and the clinical evaluation of the administration of MSCs and their derivatives, which can provide a comprehensive vision for the application of MSCs and their derivatives in future research and clinical treatment.

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A potential role of mesenchymal stem cells derived from human umbilical cord blood in ameliorating psoriasis-like skin lesion in the rats

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Folia Morphologica" are listed in PubMed.

Cited by 10 publications

References 33 publications

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Indirubin combined with umbilical cord mesenchymal stem cells to relieve psoriasis-like skin lesions in BALB/c mice

Application of Cell-Based Therapies in Veterinary Dermatology

Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis

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