A potentially functional polymorphism in the promoter region of miR-34b/c is associated with renal cell cancer risk in a Chinese population

Zhang, Shaobo; Qian, Ji; Cao, Qiang; Li, Pu; Wang, Meilin; Wang, Jian; Ju, Xingrong; Meng, Xia; Lü, Qiang; Shao, Pengfei; Zhang, Zhengdong; Qin, Chao; Chen, Yin

doi:10.1093/mutage/geu001

Cited by 41 publications

(38 citation statements)

References 23 publications

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“…Pan et al (27) reported that the CT and CT/CC genotypes of the miR-34b/c rs4938723 were associated with a significantly decreased risk of gastric cancer compared with the TT genotype. It has been shown that the pri-miR-34b/c rs4938723 C allele may increase the susceptibility to renal cell carcinoma by decreasing the activity of pri-miR-34b/c promoter (30).…”

Section: Discussionmentioning

confidence: 99%

“…miR-34a is encoded by its own transcript, while miR-34b and miR-34c share a common primary transcript (pri-miR-34b/c) (9). The promoter region of miR-34b/c transcripts contains p53-binding sites (22 Numerous studies investigated the impact of miR-34b/c rs4938723 on the risk of various cancers, but the results are inconsistent (19,(23)(24)(25)(26)(27)(28)(29)(30)(31). To the best of our knowledge, there is only one previous study regarding the impact of the miR-34b/c variant on BC risk (32).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk

et al. 2016

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Abstract. MicroRNAs (miRNAs or miRs) are a family of small non-coding RNAs that function as oncogenes or tumor suppressor genes. Recent evidence suggests that the pri-miR-34b/c rs4938723 variant is associated with the development of cancer. At present, there is an inconsistent association between the single-nucleotide polymorphism in pri-miR-34b/c and cancer in the limited studies. The present study is a case-control investigation, with 263 breast cancer (BC) patients and 221 control women, which examined the potential association of the pri-miR-34b/c rs4938723 polymorphisms with BC susceptibility. The polymorphisms were genotyped by the polymerase chain reaction restriction fragment length polymorphism method. No significant association between the pri-miR-34b/c rs4938723 variant and BC was identified [TC vs. TT: Odds ratio (OR), 0.87; 95% confidence interval (CI), 0.60-1.26; P=0.506; CC vs. TT: OR, 1.22; 95% CI, 0.61-2.47; P= 0.600; TC+CC vs. TT: OR, 0.91; 95% CI, 0.64-1.31; P= 0.648; CC vs. TT+TC: OR, 1.32; 95% CI, 0.67-2.59; P= 0.498; C vs. T: OR, 0.99; 95% CI, 0.75-1.31; P= 0.986]. However, a significant association was observed between the pri-miR-34b/c rs4938723 genotypes and clinicopathological characteristics, such a grade, progesterone receptor and human epidermal growth factor receptor 2 status were observed (P<0.05). These findings suggest that the pri-miR-34b/c rs4938723 variant may not be a risk factor for the development of BC. IntroductionBreast cancer (BC), the most prevalent type of cancer in women, is a major public and global health problem and accounts for 14% of total annual cancer fatalities worldwide (1). Similarly, BC is the most common malignancy affecting Iranian women (2). Although the etiology of BC remains to be identified, genetic factors are shown to have important roles in the pathogenesis and progress of this malignancy (3-8).MicroRNAs (miRNAs or miRs) are a class of single-stranded non-coding RNA typically 17-25 nucleotides in length that have key roles in the regulation of cellular processes by targeting mRNAs for cleavage or translational repression (9,10). They regulate the expression of genes at the post-transcriptional level by targeting the 3' untranslated regions of mRNAs. Cumulative evidence suggests that the dysregulation of miRNA expression is involved in the tumorigenesis by acting as tumor suppressors or oncogenes (11-15). Single-nucleotide polymorphisms (SNPs) or mutations in miRNA genes can affect the miRNA biosynthesis and expression of target genes, therefore resulting in diverse functional consequences and thereby possibly representing potentially important biomarkers for the prognosis of cancer (7,(16)(17)(18).The pri-miR-34b/c gene resides in a CpG island within the intron of the B-cell translocation gene 4. Therefore, it is expected that pri-miR-34b/c is co-transcribed by either the promoter of the protein-coding gene or by its own transcription initiation region, as is the case with the majority of miRNAs, whether they are intergenic or located within the i...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk

et al. 2016

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“…This is in accordance to the known role of both genes in cancer-related pathways. For example, MIR-124A is correlated with breast cancer growth and aggressiveness (86), whilst MIR-34B, which has tumor-suppressive effects through the inhibition of BCL-2 (87), is associated to renal cell cancer risk (88) and silenced in hepatocellular carcinoma (89). …”

Section: Discussionmentioning

confidence: 99%

An Integrative Analysis of Meningioma Tumors Reveals the Determinant Genes and Pathways of Malignant Transformation

Gómez¹,

Orgueira

2014

Front. Oncol.

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Meningiomas are frequent central nervous system neoplasms, which despite their predominant benignity, show sporadically malignant behavior. Type 2 neurofibromatosis and polymorphisms in several genes have been associated with meningioma risk and are probably involved in its pathogenesis. Although GWAS studies have found loci related to meningioma risk, little is known about the factors determining malignant transformation. Thus, this study is aimed to identify the genomic and transcriptomic factors influencing evolution from benignity toward aggressive phenotypes. By applying an integrative bioinformatics pipeline combining public information on a wealth of biological layers of complexity (from genetic polymorphisms to protein interactions), this study identified a module of co-expressed genes highly correlated with tumor stage and statistically linked to several genomic regions (module Quantitative Trait Loci, mQTLs). Ontology analysis of the transcription hub genes identified microtubule-associated cell-cycle processes as key drivers of such network. mQTLs and single nucleotide polymorphisms associated with meningioma stage were replicated in an alternative meningioma cohort, and integration of these results with up-to-date scientific literature and several databases retrieved a list of genes and pathways with a potentially important role in meningioma malignancy. As a result, cytoskeleton and cell–cell adhesion pathways, calcium-channels and glutamate receptors, as well as oxidoreductase and endoplasmic reticulum-associated degradation pathways were found to be the most important and redundant findings associated to meningioma progression. This study presents an integrated view of the pathways involved in meningioma malignant conversion and paves the way for the development of new research lines that will improve our understanding of meningioma biology.

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“…GATA-X transcription factors can activate or repress expression of target genes when they bind to a specific DNA sequence (A/T) GATA (A/G) in the region of promoters (Bossard et al, 1998). In recent years, some case-control studies have been conducted to determine the association between rs4938723 and multiple kinds of cancers in various types, such as hepatocellular carcinoma (Xu et al, 2011;Han et al, 2013;Son et al, 2013), colorectal cancer (Gao et al, 2013;Oh et al, 2014), renal cell cancer (Zhang et al, 2014), esophageal cancer (Yin et al, 2013), nasopharyngeal carcinoma and breast cancer (Bensen et al, 2013). However, the results are conflicting and inconclusive.…”

Section: Research Articlementioning

confidence: 99%

Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis

Lin¹,

Chen²,

Song³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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A potentially functional polymorphism in the promoter region of miR-34b/c is associated with renal cell cancer risk in a Chinese population

Cited by 41 publications

References 23 publications

Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk

Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk

An Integrative Analysis of Meningioma Tumors Reveals the Determinant Genes and Pathways of Malignant Transformation

Association between a Polymorphism in miR-34b/c and Susceptibility to Cancer - a Meta-analysis

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