2021
DOI: 10.48550/arxiv.2105.07570
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A powerful test for differentially expressed gene pathways via graph-informed structural equation modeling

Abstract: A major task in genetic studies is to identify genes related to human diseases and traits to understand functional characteristics of genetic mutations and enhance patient diagnosis. Besides marginal analyses of individual genes, identification of gene pathways, i.e., a set of genes with known interactions that collectively contribute to specific biological functions, can provide more biologically meaningful results. Such gene pathway analysis can be formulated into a high-dimensional two-sample testing proble… Show more

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