A Pox Disease in Monkeys Transmitted to Man

McNulty, Wilbur P.

doi:10.1001/archderm.1968.01610090058008

Cited by 37 publications

(7 citation statements)

References 13 publications

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“…Infection was also detected in humans handling the monkeys (Crandell et al, 1969; McNulty et al, 1968). Experimental infection of rabbits resulted in productive infections in German checker rabbits but not in New Zealand white rabbits.…”

Section: Yatapoxvirusesmentioning

confidence: 99%

Poxviruses and the evolution of host range and virulence

Haller¹,

Chen²,

McFadden³

et al. 2014

Infection, Genetics and Evolution

251

257

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Poxviruses as a group can infect a large number of animals. However, at the level of individual viruses, even closely related poxviruses display highly diverse host ranges and virulence. For example, variola virus, the causative agent of smallpox, is human-specific and highly virulent only to humans, whereas related cowpox viruses naturally infect a broad spectrum of animals and only cause relatively mild disease in humans. The successful replication of poxviruses depends on their effective manipulation of the host antiviral responses, at the cellular-, tissue- and species-specific levels, which constitutes a molecular basis for differences in poxvirus host range and virulence. A number of poxvirus genes have been identified that possess host range function in experimental settings, and many of these host range genes target specific antiviral host pathways. Herein, we review the biology of poxviruses with a focus on host range, zoonotic infections, virulence, genomics and host range genes as well as the current knowledge about the function of poxvirus host range factors and how their interaction with the host innate immune system contributes to poxvirus host range and virulence. We further discuss the evolution of host range and virulence in poxviruses as well as host switches and potential poxvirus threats for human and animal health.

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Section: Yatapoxvirusesmentioning

confidence: 99%

Poxviruses and the evolution of host range and virulence

Haller¹,

Chen²,

McFadden³

et al. 2014

Infection, Genetics and Evolution

251

257

View full text Add to dashboard Cite

show abstract

“…In the wild, transmission from the reservoir of affected monkey populations to humans is believed to be through mosquitoes as vectors. Direct skin inoculation was implicated in the outbreaks that occurred in animal handlers in the United States 5–7 . The disease produced by the tanapox virus is characterized by a mild febrile illness lasting 3–4 days during which one or two pock‐like lesions appear, usually on the upper part of the body.…”

Section: Discussionmentioning

confidence: 99%

Tanapox Virus Infection

Croitoru

Birgé

Rudikoff

et al. 2002

Skinmed

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“…In addition to MPV, other poxviruses also produce poxlike diseases in nonhuman primates. These include smallpox (6,13,36,58,59), Yaba tumor virus (10), Yaba-related virus (15,22,38,53,57), and molluscum contagiosum (27). Most species of monkeys are not very susceptible to experimental infection with smallpox virus (5,14,36,58).…”

Section: Classificationmentioning

confidence: 99%