A ppb level turn-on fluorescence chemosensor for the detection of Zn2+

Jiang, Jian-Qiao; Sun, Chun‐Lin; Shi, Zi‐Fa; Zhou, Xu; Zhang, Hao‐Li

doi:10.1016/j.snb.2015.05.122

Cited by 14 publications

(3 citation statements)

References 28 publications

(37 reference statements)

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“…The detection limit for Zn 2+ is estimated as low as ∼0.76 μM using the equation of C DL = 3S b m –1 (defined by IUPAC, where S b is the standard deviation from 10 blank solutions, and m represents the slope of the calibration curve) . Such a low detection limit for Zn 2+ falls far below the normal concentration level of Zinc ion in human body (about 10 μM) . Therefore, we expect that TPA-1 can be used as a “turn-on” biosensor for specific detection of Zn 2+ in biological systems.…”

Section: Resultsmentioning

confidence: 98%

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Multifunctional Metallo-Organic Vesicles Displaying Aggregation-Induced Emission: Two-Photon Cell-Imaging, Drug Delivery, and Specific Detection of Zinc Ion

Wei

Wang

Huang

et al. 2018

ACS Appl. Nano Mater.

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Molecules displaying aggregation-induced emission (AIE) property can hardly self-assemble into vesicles desired in design of theranostics. We report the formation of metallo-organic AIE vesicles with triarylamine carboxylate (TPA-1) and Zn2+ ions. TPA-1 shows a great binding affinity to Zn2+ as a fluorescence turn-on sensor. The vesicles exhibited high fluorescence-emission property under two-photon mode which endows them very good cell imaging ability. Drug-loading experiments suggest a loading capacity for the model anticancer drug 5-fluorouracil (5-Fu) can reach up to 53.4%, and sustained release of the drug is possible in biological environment. This is the first report of supramolecular coordination fluorescent vesicles based on AIE molecule. Further study reveals the fluorescence enhancement of TPA-1 can only be triggered by Zn2+, suggesting the ability of specific detection of Zn2+. This study indicates that the formation of metallo-organic vesicles can be a multiplatform for cell-imaging, drug carrier, and metal ions detection.

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Section: Resultsmentioning

confidence: 98%

“…42 Such a low detection limit for Zn 2+ falls far below the normal concentration level of Zinc ion in human body (about 10 μM). 43 Therefore, we expect that TPA-1 can be used as a "turn-on" biosensor for specific detection of Zn 2+ in biological systems.…”

Section: Acs Applied Nano Materialsmentioning

confidence: 99%

Multifunctional Metallo-Organic Vesicles Displaying Aggregation-Induced Emission: Two-Photon Cell-Imaging, Drug Delivery, and Specific Detection of Zinc Ion

Wei

Wang

Huang

et al. 2018

ACS Appl. Nano Mater.

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“…Therefore, the development of a new method for Zn 2+ ion detection in environmental and biological systems is a critical need. In recent studies, processes using fluorescence chemosensors were found to deliver the best analytical techniques for monitoring metal ions in solution, due to their effective features such as simplicity, high sensitivity, ease of function, quick response to fluorogenic and chromogenic colorimetric changes, and biocompatibility in cell imaging, plus generating inexpensive detection systems that delivered considerable advantages over other methods …”

Section: Introductionmentioning

confidence: 99%

Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn²⁺ and bioimaging studies in live cells

et al. 2019

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A phenothiazine-rhodamine (PTRH) fluorescent dyad was synthesized and its ability to selectively sense Zn 2+ ions in solution and in in vitro cell lines was tested using various techniques. When compared with other competing metal ions, the PTRH probe showed the high selectivity for Zn 2+ ions that was supported by electronic and emission spectral analyses. The emission band at 528 nm for the PTRH probe indicated the ring closed form of PTRH, as for Zn 2+ ion binding to PTRH, the λ em get shift to 608 nm was accompanied by a pale yellow to pink colour (under visible light) and green to pinkish red fluorescence emission (under UV light) due to ring opening of the spirolactam moiety in the PTRH ligand. Spectral overlap of the donor emission band and the absorption band of the ring opened form of the acceptor moiety contributed towards the fluorescence resonance energy transfer ON mechanism for Zn 2+ ion detection. The PTRH sensor had the lowest detection limit for Zn 2+ , found to be 2.89 × 10 −8 M. The sensor also demonstrated good sensing application with minimum toxicity for in vitro analyses using HeLa cells.

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Recent studies focusing on the development of fluorescence probes for zinc ion

Wang

Kong

et al. 2021

Coordination Chemistry Reviews

100

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A ppb level turn-on fluorescence chemosensor for the detection of Zn2+

Cited by 14 publications

References 28 publications

Multifunctional Metallo-Organic Vesicles Displaying Aggregation-Induced Emission: Two-Photon Cell-Imaging, Drug Delivery, and Specific Detection of Zinc Ion

Multifunctional Metallo-Organic Vesicles Displaying Aggregation-Induced Emission: Two-Photon Cell-Imaging, Drug Delivery, and Specific Detection of Zinc Ion

Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn²⁺ and bioimaging studies in live cells

Recent studies focusing on the development of fluorescence probes for zinc ion

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A ppb level turn-on fluorescence chemosensor for the detection of Zn2+

Cited by 14 publications

References 28 publications

Multifunctional Metallo-Organic Vesicles Displaying Aggregation-Induced Emission: Two-Photon Cell-Imaging, Drug Delivery, and Specific Detection of Zinc Ion

Multifunctional Metallo-Organic Vesicles Displaying Aggregation-Induced Emission: Two-Photon Cell-Imaging, Drug Delivery, and Specific Detection of Zinc Ion

Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn2+ and bioimaging studies in live cells

Recent studies focusing on the development of fluorescence probes for zinc ion

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Product

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Phenothiazine–rhodamine‐based colorimetric and fluorogenic ‘turn‐on' sensor for Zn²⁺ and bioimaging studies in live cells