A practical approach to improve safety and management in chemotherapy units based on the PROCHE – Programme for optimisation of the chemotherapy network monitoring program

Scotté, Florian; Oudard, Stéphane; Aboudagga, Haïl; Elaidi, Réza; Bonan, Brigitte

doi:10.1016/j.ejca.2012.08.025

Cited by 30 publications

(20 citation statements)

References 6 publications

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“…However, few articles on the implementation of this process are available, with a single paper in France in particular, without feasibility study (Scotté et al, 2013).…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…One way to optimise chemotherapy preparation is to anticipate prescription by using an outsourced phone call platform (Wennberg, Marr, Lang, O'Malley, & Bennett, ). The benefits of pre‐preparing chemotherapy are already known: significant reductions in mean hospital stay and drug wastage, significant increase in bed occupancy rates, fewer treatment interruptions, better management of side effects, lower rate of pain and fatigue (Bonan et al, ; Scotté, Oudard, Aboudagga, Elaidi, & Bonan, ; Soh et al, ). However, few articles on the implementation of this process are available, with a single paper in France in particular, without feasibility study (Scotté et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Optimisation of chemotherapy prescription and preparation in an ambulatory unit: Validation of the OPTIMA program

et al. 2019

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Objective We implemented the two‐step OPTIMA program to anticipate chemotherapy prescription which aims to assess the discrepancy rate between anticipated and real prescription and its impact on waiting time and quality of care. Methods This prospective study included cancer patients receiving any intravenous chemotherapy. The OPTIMA program consists in a nurse phone call and a blood sample two days before the planned treatment. Collected information and biological results were used by a physician to issue a non‐effective (step 1) or effective (step 2) anticipated prescription the day before the consultation. The real prescription was given as usual by another physician on the day of the consultation. Waiting time was collected, and patients’ satisfaction with care was assessed with the OUT‐PATSAT35 questionnaire. Results Respectively, 540 and 979 consultations (283 and 294 patients) were analysed in both steps. The discrepancy rate was 8.7% (step 1). In routine practice, the OPTIMA program (step 2) reduced patients’ waiting time (median time 55 vs. 95 min, p < 0.001). A high general care satisfaction score was observed in both steps (80.7% and 80.2%). Conclusions This anticipation program demonstrated the accuracy of chemotherapy prescription, whatever the regimen and cancer site, and its impact on waiting time optimisation.

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“…However, few articles on the implementation of this process are available, with a single paper in France in particular, without feasibility study (Scotté et al, 2013).…”

Section: Backg Rou N Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimisation of chemotherapy prescription and preparation in an ambulatory unit: Validation of the OPTIMA program

et al. 2019

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“…[29][30][31] For example, at the George Pompidou Hospital in Paris, a simple nurse-driven PROCHE program results in efficient chemotherapy delivery. 32 The overall rate of toxicities with OGS-12 is akin to other trials. 12 A trend toward lesser hematological toxicity may be ascribed to the use of CDDP, which is less myelosuppressive than carboplatin used in the St Jude's study.…”

Section: The Results Of the European And American Osteosarcoma Studymentioning

confidence: 99%

“…The rationale for achieving greater efficiency with limited resources is to relocate them to derive maximum benefit . For example, at the George Pompidou Hospital in Paris, a simple nurse‐driven PROCHE program results in efficient chemotherapy delivery …”

Section: Discussionmentioning

confidence: 99%

Osteosarcoma journey over two decades in India: Small steps, big changes

Bajpai

Chandrasekharan

Simha

et al. 2019

Pediatric Blood & Cancer

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Background The management of osteosarcoma is challenging especially in lower‐income and middle‐income countries, and there is an unmet need to evolve efficient and sustainable chemotherapy regimens. Methods We compared the outcomes in nonmetastatic osteosarcoma patients treated with three sequential non‐high‐dose methotrexate‐based combination chemotherapy protocols at a single tertiary care center over two decades. The first protocol, OGS‐99, involved dose‐intense, alternating dyads of three drugs: doxorubicin (Dox), cisplatin (CDDP), and ifosfamide (Ifo). The second protocol, OGS‐99 enhanced, included OGS‐99 drugs with etoposide and enhanced supportive care. The OGS‐12 protocol involved dose‐dense administration of eight sequential dyads of Dox, CDDP and Ifo, universal growth factor prophylaxis and targeted nutritional support. Event‐free survival (EFS), overall survival (OS), and toxicity were reported using a retrospective chart review in the OGS‐99 and OGS‐99 enhanced protocols and prospectively in the OGS‐12 protocol. Results A total of 41, 94, and 385 treatment‐naïve, consecutive, nonmetastatic patients with extremity osteosarcoma were treated with the OGS‐99 (2000–2005), OGS‐99 enhanced (2010), and OGS‐12 (2011–2016), respectively. At a median follow‐up of 19, 86, and 39 months, the five‐year EFS rates were 38%, 50%, and 62% in the OGS‐99, OGS‐99 enhanced, and OGS‐12, respectively. The corresponding rates of five‐year OS were nonevaluable, 60% and 77%, respectively, with acceptable rates of grade 3–4 toxicities: febrile neutropenia (40%), thrombocytopenia (36%), anemia (51%), and 1% deaths related to toxicity. Conclusions Sequential selection of an intelligent, dose‐dense chemotherapy regimen together with enhanced supportive care resulted in marked improvement in outcomes of nonmetastatic osteosarcoma and this “small steps—big changes” model deserves wider recognition and usage.

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“…Mobile apps are developed, and well accepted by patients, for instance to manage chemotherapy toxicity (McCann et al 2009). Phone call platforms are created to gather information on patient's status, to avoid side effects leading to unscheduled hospitalizations (Coriat et al 2012) but also to recover patient data before treatment, which allows to prepare chemotherapy drugs in advance and reduces waiting times (Scotté et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Patient-hospital communication: A platform to improve outpatient chemotherapy

Lamé

Jouini

Cardinal

et al. 2016

2016 Winter Simulation Conference (WSC)

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We apply Discrete Event Simulation (DES) to a system of two strongly interconnected departments, an outpatient oncology clinic for chemotherapy delivery, and the pharmacy unit that prepares the chemotherapy drugs. The model is developed in close collaboration with the French hospital Henri Mondor, and is validated using real data. The objective is to identify sources of patient waiting times in the outpatient oncology clinic and to identify relevant corrective actions. We show that the coordination between the two departments is the key barrier to higher performance. Solutions are proposed based on increased information sharing and obtaining advanced information on patient status, to allow advanced drug preparation. A two-phase project for improvement is proposed. This paper contributes to the literature on multi-department simulation, which is still rare in healthcare OR compared to onedepartment studies.

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A practical approach to improve safety and management in chemotherapy units based on the PROCHE – Programme for optimisation of the chemotherapy network monitoring program

Cited by 30 publications

References 6 publications

Optimisation of chemotherapy prescription and preparation in an ambulatory unit: Validation of the OPTIMA program

Optimisation of chemotherapy prescription and preparation in an ambulatory unit: Validation of the OPTIMA program

Osteosarcoma journey over two decades in India: Small steps, big changes

Patient-hospital communication: A platform to improve outpatient chemotherapy

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