A practical approach to vascular pathology in pulmonary hypertension

Grünberg, Katrien; Mooi, Wolter J.

doi:10.1016/j.mpdhp.2013.06.013

Cited by 3 publications

(2 citation statements)

References 69 publications

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“…Biopsy pathology has no significant role to play in the demonstration of PH in this group of diseases, or in the assessment of its severity, but it does provide some angle on pathogenesis. Various distinct histological patterns of hypertensive pulmonary vascular disease have been identified in past decades, and these can be linked, to some extent, to different clinical contexts [4]. It is plausible that these various patterns and the differences between them reflect differences in pathogenesis and are, therefore, of potential therapeutic interest.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary hypertensive vasculopathy in parenchymal lung diseases and/or hypoxia

2017

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Pulmonary hypertension (PH) with complicating chronic lung diseases and/or hypoxia falls into group 3 of the updated classification of PH. Patients with chronic obstructive lung disease (COPD), diffuse lung disease (such as idiopathic pulmonary fibrosis (IPF)) and with sleep disordered breathing are particularly exposed to the risk of developing PH. Although PH in such a context is usually mild, a minority of patients exhibit severe haemodynamic impairment, defined by a mean pulmonary arterial pressure (mPAP) of ≥35 mmHg or mPAP values ranging between 25 mmHg and 35 mmHg with a low cardiac index (<2 L·min·m). The overlap between lung parenchymal disease and PH heavily affects life expectancy in such a patient population and complicates their therapeutic management. In this review we illustrate the pathological features and the underlying pathophysiological mechanisms of pulmonary circulation in chronic lung diseases, with an emphasis on COPD, IPF and obstructive sleep apnoea syndrome.

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Section: Introductionmentioning

confidence: 99%

Pulmonary hypertensive vasculopathy in parenchymal lung diseases and/or hypoxia

2017

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“…Evaluation of vasculopathy was performed according to previously described patterns [7]. Immunohistochemical staining with Ki-67, histone H3 and cleaved caspase 3 was performed to determine proliferation and apoptosis of endothelial cells.…”

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confidence: 99%