The assimilation of microwave and infrared (IR) radiance satellite observations within numerical weather prediction (NWP) models have been an important component in the effort of improving the accuracy of analysis and forecast. Such capabilities were implemented during the development of the high-resolution Copernicus European Regional Reanalysis (CERRA), funded by the Copernicus Climate Change Services (C3S). The CERRA system couples the deterministic system with the ensemble data assimilation to provide periodic updates of the background error covariance matrix. Several key factors for the assimilation of radiances were investigated, including appropriate use of variational bias correction (VARBC), surface-sensitive AMSU-A observations and observation error correlation. Twenty-one-day impact studies during the summer and winter seasons were conducted. Generally, the assimilation of radiances has a small impact on the analysis, while greater impacts are observed on short-range (12 and 24-h) forecasts with an error reduction of 1–2% for the mid and high troposphere. Although, the current configuration provided less accurate forecasts from 09 and 18 UTC analysis times. With the increased thinning distances and the rejection of IASI observation over land, the errors in the analyses and 3 h forecasts on geopotential height were reduced up to 2%.