A practical guide to invasive neurophysiology in patients with deep brain stimulation

Neumann, Wolf‐Julian; Köhler, Richard; Kühn, Andrea A.

doi:10.1016/j.clinph.2022.05.004

Cited by 14 publications

(15 citation statements)

References 71 publications

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“…Bipolar recordings were shown to be helpful in an intraoperative setting during lead extension along the stereotactic trajectory; however, although currently the only alternative option, the interpretation of bipolar recordings in steadily implanted devices relies on careful visual inspection and requires immense electrophysiological expertise [ 5 ]. The issue of bipolar montages in DBS has been further discussed by Neumann and colleagues [ 31 ]. Additionally, a guide to electrophysiologically informed programming using commercially available sensing devices has been proposed by two renowned DBS centers [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

et al. 2022

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Intra- and perioperatively recorded local field potential (LFP) activity of the nucleus subthalamicus (STN) has been suggested to guide contact selection in patients undergoing deep brain stimulation (DBS) for Parkinson’s disease (PD). Despite the invention of sensing capacities in chronically implanted devices, a comprehensible algorithm that enables contact selection using such recordings is still lacking. We evaluated a fully automated algorithm that uses the weighted average of bipolar recordings to determine effective monopolar contacts based on elevated activity in the beta band. LFPs from 14 hemispheres in seven PD patients with newly implanted directional DBS leads of the STN were recorded. First, the algorithm determined the stimulation level with the highest beta activity. Based on the prior determined level, the directional contact with the highest beta activity was chosen in the second step. The mean clinical efficacy of the contacts chosen using the algorithm did not statistically differ from the mean clinical efficacy of standard contact selection as performed in clinical routine. All recording sites were projected into MNI standard space to investigate the feasibility of the algorithm with respect to the anatomical boundaries of the STN. We conclude that the proposed algorithm is a first step towards LFP-based contact selection in STN-DBS for PD using chronically implanted devices.

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Section: Discussionmentioning

confidence: 99%

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

et al. 2022

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“…95 Circadian data can also be obtained directly from the human brain with clinical brain computer interfaces for deep brain stimulation (DBS). 96 DBS is a neurosurgical treatment, for which electrodes are implanted into the basal ganglia and electrical stimulation is applied with robust therapeutic efficacy. 97 The newest generation of deep brain stimulation now allows for recording invasive brain activity, such as beta activity that was described for the MPTP non-human primate model above, over months across the circadian cycle.…”

Section: Ath Iesmentioning

confidence: 99%

“…Wearables and digital health applications are currently emerging that can track medication intake and rhythmic fluctuations of symptoms and side‐effects 95 . Circadian data can also be obtained directly from the human brain with clinical brain computer interfaces for deep brain stimulation (DBS) 96 . DBS is a neurosurgical treatment, for which electrodes are implanted into the basal ganglia and electrical stimulation is applied with robust therapeutic efficacy 97 .…”

Section: Clinical α‐Synucleinopathiesmentioning

confidence: 99%

Sleep and circadian rhythms in α‐synucleinopathies—Perspectives for disease modification

et al. 2023

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The global north is facing an unprecedented rise in the prevalence of neurodegenerative diseases. The increasing incidence of Parkinson's disease is being referred to as a pandemic. The reason for the enormous increase is only partly understood. Lifestyle factors are known to play a role, but they alone cannot account for the surge. One factor that—although being recognized as important—has not been explored in detail so far is the influence of circadian rhythms. Sleep and circadian rhythm disruption are known as key factors in neurodegeneration, and their occurrence during early disease stages suggests a causal role in the pathogenesis. Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) has been identified as a prodromal state of α‐synucleinopathies, such as Parkinson's disease, Lewy body dementia, and multiple system atrophy offering a window for insights into the early development of these diseases. Even though REM sleep is the sleep state most pronounced, driven and modulated by the circadian timing system, specific circadian abnormalities have not been described in iRBD. Novel experimental and clinical approaches exploiting the molecular circuitry underlying circadian timekeeping hold promise to disentangle some of the pathophysiologic mechanisms of α‐synucleinopathies. In this review, we summarize current knowledge on sleep and circadian rhythm disruptions in α‐synucleinopathies with an emphasis on molecular aspects and therapeutic potentials. These insights might contribute to our understanding of the pathogenesis of neurodegenerative diseases and may allow therapeutic interventions addressing the disturbed circadian system at the early stage of disease.

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“…It could also record the multiunit activity of neurons, providing electrophysiological images. In TBI, it includes electroencephalography to help doctors and researchers to judge the brain condition [3]. This article will mainly focus on two emerging technologies focusing on TBI treatments.…”

Section: Introductionmentioning

confidence: 99%

Neuromodulation Therapies for Traumatic Brain Injury

Sun¹

2023

HSET

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Traumatic brain injury (TBI) is associated with high disability and death rates worldwide. Medically refractory patients could turn to neuromodulation therapies. Yet there were no essays focused on this review. This essay introduces two main neuromodulation theories, including their treatment principles and therapeutic effects. The mentioned theories were vagus nerve stimulation (VNS) and deep brain stimulation (DBS). VNS was proved to have a good performance in improving the consciousness of severe patients at the TBI early stage. It could also help reduce secondary brain injuries. While clinical research on DBS also proves a significant advantage in the recovery of minimally conscious state (MCS) patients, especially in the prolonged disorder of conscientiousness (DOC) patients. DBS also proves to be effective in improving the arousal mechanism of cognitive and motor function of re-waken patients, especially combined with rehabilitation treatments. The patient scenarios of these two neuromodulation methods were discussed, as were the advantages and limitations.

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A practical guide to invasive neurophysiology in patients with deep brain stimulation

Cited by 14 publications

References 71 publications

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

Local Field Potential-Guided Contact Selection Using Chronically Implanted Sensing Devices for Deep Brain Stimulation in Parkinson’s Disease

Sleep and circadian rhythms in α‐synucleinopathies—Perspectives for disease modification

Neuromodulation Therapies for Traumatic Brain Injury

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