A Practical Overview on the Molecular Biology of Meningioma

Delgado-López, Pedro David; Cubo-Delgado, Esther; González-Bernal, Jerónimo J.; Martín-Alonso, Javier

doi:10.1007/s11910-020-01084-w

Cited by 24 publications

(31 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of pial blood supply in the development of peritumoral edema in meningiomas is well described. Of note, Delgado-Lopez et al [ 47 ] recently reviewed causes for peritumoral edema, and according to their observations, the most important cause for edema seems to be the tumor size, which usually reaches a larger volume in this area compared to other locations, which is probably due to the late perception of cognitive symptoms. Furthermore, higher tumor grade and absence of a clear demarcation between the lesion and healthy parenchyma (which was particularly high in this cohort with 35%) also seemed to be associated with edema.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological Outcomes after Surgery for Olfactory Groove Meningiomas

Constanthin

Gondar

Fellrath

et al. 2021

Cancers

View full text Add to dashboard Cite

Background: In recent years, several studies have reported abnormal pre- and postoperative neuropsychological functioning in patients with meningiomas located in the prefrontal cortex (notably the ventromedial region). In the case of olfactory groove meningiomas, the tumor is in direct contact with the inferior aspect of the prefrontal cortex, a cortical region with crucial roles in decision-making, cognition and memory functions, potentially negatively impacting neuropsychological functions. Materials and Methods: We retrospectively compared pre- and post-operative neuropsychological testing of 17 patients undergoing surgical removal of olfactory groove meningiomas in our institution between January 2013 and December 2018. Neuropsychological results were obtained from the patients’ medical history and normalized as z-scores of their respective cognitive functions. Results: Assessment of cognitive follow-up showed an important heterogeneity among patients. Pre-operative cognitive impairment was observed in most patients, particularly in cognitive flexibility (mean z-score: −1.35). Immediate post-operative cognitive status showed an overall impairment in all domains of cognition, significant for the domains of attention (p = 0.0273) and flexibility (p = 0.0234) and almost significant for the domain of language (p = 0.0547). The late follow-up at one year showed a trend towards general improvement, although attention and flexibility remained impaired. Discussion: Olfactory groove meningiomas impact pre-frontal cortex cognitive functions, particularly in the domain of cognitive flexibility. After an initial postoperative worsening, patients tended to improve in most aspects after one year, aside from cognitive flexibility and attention.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuropsychological Outcomes after Surgery for Olfactory Groove Meningiomas

Constanthin

Gondar

Fellrath

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…POLR2A, PIK3CA, SMO, TERT, and SMARCE1 among others, or even combinations of them. 24 Some studies have shown that specific gene mutations seem to be predisposed to certain tumor subtypes and locations. 25 NF2 mutant meningiomas generally occur in lateral and posterior skull base or parasagittal sinus, falcate, annular and intraventricular meningiomas.…”

Section: Discussionmentioning

confidence: 99%

Giant Intraparenchymal Meningioma in a Female Child: Case Report and Literature Review

Guo¹,

Liang²,

Wang³

et al. 2021

CMAR

View full text Add to dashboard Cite

Background Intraparenchymal meningiomas without dural attachment are extremely rare, especially in female children. To our knowledge, fibrous intraparenchymal meningioma located in the temporal lobe has never been reported in female children. The significance in the differential diagnosis of lesions in the temporal lobe should be emphasized. Case Presentation A 12-year-old girl was admitted to our hospital, complaining of recurrent generalized seizures for 2 months. Magnetic resonance imaging demonstrated a solid lesion located in the temporal lobe. The lesion underwent gross total resection. Histopathological examination indicated that the lesion was a fibrous meningioma. Postoperative rehabilitation was uneventful. Conclusion This case report presents an extremely unusual intraparenchymal fibrous meningioma of the temporal lobe with peritumoral edema and reviewed 21 intraparenchymal meningioma cases in children and to discuss the clinical presentation and treatment, differential diagnosis, and radiological features.

show abstract

“…Next-generation sequencing revealed recurrent somatic mutations in the neurofibromin 2 (NF2), TNF receptor associated factor 7 (TRAF7), Krüppel-like factor 4 (KLF4), AKT serine/threonine kinase 1 (AKT1), smoothened (SMO), and phosphatidylinositol-4,5bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) genes, which are collectively found in around 80% of sporadic MGMs and are associated with tumor location, histologic subtype, and clinical outcome [5,6,9,[15][16][17]. The most common chromosomal abnormality in MGM is found in chromosome 22 and occurs 40-70% of grade I tumors.…”

Section: Molecular Changes and Novel Molecularly-targeted Therapeutic Strategiesmentioning

confidence: 99%

“…In addition to histopathological analysis, positron emission tomography (PET) imaging has contributed with the distinction between low-and high-grade MGMs [4]. Also, other classification methods have been more recently proposed, based on molecular markers such as DNA methylation profiles [5,6].…”

Section: Introductionmentioning

confidence: 99%

Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers in Meningioma

Roesler¹,

Souza²,

Isolan³

2021

Preprint

View full text Add to dashboard Cite

Meningioma (MGM) is the most common type of intracranial tumor in adults. The validation of novel prognostic biomarkers to better inform tumor stratification and clinical prognosis is urgently needed. Many molecular and cellular alterations have been described in MGM tumors over the past few years, providing a rational basis for the identification of biomarkers and therapeutic targets. The role of receptor tyrosine kinase (RTKs), including those of the ErbB family of receptors, as oncogenes has been well established in several cancer types. Here, we review histological, molecular, and clinical evidence suggesting that RTKs, including the epidermal growth factor receptor (EGFR, ErbB 1), as well as other members of the ErbB family, may be useful as biomarkers in MGM.

show abstract

A Practical Overview on the Molecular Biology of Meningioma

Cited by 24 publications

References 90 publications

Neuropsychological Outcomes after Surgery for Olfactory Groove Meningiomas

Neuropsychological Outcomes after Surgery for Olfactory Groove Meningiomas

Giant Intraparenchymal Meningioma in a Female Child: Case Report and Literature Review

Receptor Tyrosine Kinases as Candidate Prognostic Biomarkers in Meningioma

Contact Info

Product

Resources

About