A practical review of dermoscopy for pediatric dermatology part I: Melanocytic growths

Kaushik, Anshika; Natsis, Nicola E.; Gordon, Samantha; Seiverling, Elizabeth V.

doi:10.1111/pde.14291

Cited by 6 publications

(2 citation statements)

References 66 publications

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“…Lesions with a starburst pattern are expected to grow symmetrically in all directions with homogenous blue-black color changes before undergoing involution; lesions that do not follow this course should be excised ( 54 ). Dynamic changes in nevi are not uncommon in children and a symmetrical spitzoid lesion is unlikely to be melanoma in this population, therefore, clinicians may defer to clinical context to determine whether to pursue excision or monitoring ( 54 , 57 ).…”

Section: Dermoscopymentioning

confidence: 99%

The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification

2022

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Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions.

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Section: Dermoscopymentioning

confidence: 99%

The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification

2022

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“…A modified pediatric two-step algorithm aids in diagnosis; melanomas show structureless areas, shiny white lines, and atypical vessels, whereas congenital nevi commonly show patterns of dots and globules and reticular networks. [ 7 ]…”

Section: Discussionmentioning

confidence: 99%

Pediatric Melanoma Arising in a Background of Melanocytic Nevi

Jamir,

Khonglah,

Harris

et al. 2023

Indian Dermatology Online Journal

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Malignant melanoma is an aggressive neoplasm primarily involving the skin. They may arise de novo or from a premalignant melanocytic lesion. Melanomas are primarily known to occur in adults. Pediatric melanomas (PM) are rare and predominantly occur de novo following ultraviolet deoxyribonucleic acid (DNA) damage. They may also be associated with the presence of congenital melanocytic nevi. We report a rare case of a 6-year-old child with multiple melanocytic nevi subsequently diagnosed with melanoma of the back and metastatic disease.

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