A pragmatic approach to the management of menopause

Lega, Iliana C.; Fine, Alexa; Antoniades, Margarita Lam; Jacobson, Michelle

doi:10.1503/cmaj.221438

Cited by 6 publications

(6 citation statements)

References 52 publications

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“…We agree with Lega and colleagues 1 that menopausal hormone therapy (MHT) has been shown in randomized controlled trials (RCTs) to be effective and safe for treating problematic vasomotor symptoms related to menopause. We also agree that treating menopausal vasomotor symptoms is important to decrease later life risks for heart disease and osteoporotic fracture.…”

supporting

confidence: 62%

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Don’t ignore perimenopause

Prior,

Hitchcock,

Shirin

et al. 2023

CMAJ

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supporting

confidence: 62%

“…For women or people born with ovaries who do not wish to, or cannot, take estrogen-based therapy for vasomotor symptoms, oral micronized progesterone has been shown to be both effective and safe in menopause in an RCT, but this practical information was not provided in Lega and colleagues’ review. 1 , 2 …”

mentioning

confidence: 99%

Don’t ignore perimenopause

Prior,

Hitchcock,

Shirin

et al. 2023

CMAJ

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“…More recently, a review in the Canadian Medical Association Journal entitled “A Pragmatic Approach to the Management of Menopause,” reported that, despite early concerns, increasing evidence shows a possible reduction in coronary artery disease with MHT among patients who start MHT before age 60 years or within 10 years of menopause. 24 Furthermore, they note that both RCTs and observational studies consistently show that an association exists between MHT and reductions of coronary artery disease events among women. Lega et al.…”

Section: Moving Forwardmentioning

confidence: 99%

“…note that the metabolic benefits of MHT include an improvement in lipid profile (an increase in high-density lipoprotein and a decrease in low-density lipoprotein) and that some studies have suggested an improvement in insulin sensitivity with a reduction in the risk of diabetes. 24 …”

Section: Moving Forwardmentioning

confidence: 99%

Women’s Heart Health and the Menopausal Transition: Two Faces of the Same Coin

Norris,

Tegg,

Ahmed

et al. 2024

CJC Open

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“…Additionally, the potential negative consequences associated with extended estrogen therapy encompass vaginal hemorrhage, perineal pain, and the development of breast cancer. 13,14,15 Consequently, further research is required to identify alternative agents capable of producing similar advantageous outcomes to estrogen with minimal or no adverse effects.…”

mentioning

confidence: 99%

The Potential Health Benefit of Cowpea Estrogen-like Activity to Restore Vaginal Epithelial Cells Thinning Due to Menopausal Syndrome

2024

TJNPR

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This is achieved through the regulation of vaginal epithelial thickness and the facilitation of antimicrobial peptide synthesis through receptorbinding interactions. 3,4 Estrogen is commonly employed as a form of hormonal replacement therapy in the treatment of many illnesses, such as vaginal atrophy-related conditions in women experiencing menopause. The Women's Health Initiative (WHI) has highlighted concern regarding the lack of regular administration of estrogen replacement medication as a prophylactic measure for many patients. 5,6 Cowpeas contain genistein, a prominent isoflavone found in legume plants. Genistein is a natural flavonoid that has a strong affinity for the estrogen receptor (ER) due to its chemical structure resembling 17βestradiol. 7,8,9 According to a previous study, genistein acts similarly to estrogen in living organisms and in lab settings, promoting mammary gland growth and boosting the growth of MCF-7 cell tumors in mice that have had their ovaries removed. 10,11 In support of this finding, our prior research has already established the correlation between estrogen treatment and the promotion of vaginal epithelial cell repair following ovariectomy (OVX) through key regulatory genes. 12 Moreover, a positive correlation was demonstrated between the initiation of menopausal hormone therapy and the occurrence of Alzheimer's disease and all-cause dementia, even among women who initiated treatment at the age of 55 years or younger. Additionally, the potential negative consequences associated with extended estrogen therapy encompass vaginal hemorrhage, perineal pain, and the development of breast cancer. 13,14,15 Consequently, further research is required to identify alternative agents capable of producing similar advantageous outcomes to estrogen with minimal or no adverse effects.

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A pragmatic approach to the management of menopause

Cited by 6 publications

References 52 publications

Don’t ignore perimenopause

Don’t ignore perimenopause

Women’s Heart Health and the Menopausal Transition: Two Faces of the Same Coin

The Potential Health Benefit of Cowpea Estrogen-like Activity to Restore Vaginal Epithelial Cells Thinning Due to Menopausal Syndrome

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