A prebiotic, short-chain fructo-oligosaccharides promotes peak bone mass and maintains bone mass in ovariectomized rats by an osteogenic mechanism

Porwal, Konica; Pal, Subhashis; Kulkarni, Chirag; Singh, Prati Pal; Sharma, Shivani; Singh, Punj Lata; Prajapati, Gurudayal; Gayen, Jiaur R.; Ampapathi, Ravi Sankar; Mullick, Ashim; Chattopadhyay, Naibedya

doi:10.1016/j.biopha.2020.110448

Cited by 27 publications

(26 citation statements)

References 40 publications

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“…In addition, a study reported that treatment with FOS significantly enhanced bone health in Ovx rats by enhancing the butyrate levels in serum. 144 …”

Section: Harnessing the Immunoporotic Role Of Gut Microbiota (Gm)mentioning

confidence: 99%

The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis

Srivastava¹,

Sapra²

2022

JIR

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Discoveries in the last few years have emphasized the existence of an enormous breadth of communication between bone and the immune system in maintaining skeletal homeostasis. Originally, the discovery of various factors was assigned to the immune system viz. interleukin (IL)-6, IL-10, IL-17, tumor necrosis factor (TNF)-α, receptor activator of nuclear factor kappa B ligand (RANKL), nuclear factor of activated T cells (NFATc1), etc., but now these factors have also been shown to have a significant impact on osteoblasts (OBs) and osteoclasts (OCs) biology. These discoveries led to an alteration in the approach for the treatment of several bone pathologies including osteoporosis. Osteoporosis is an inflammatory bone anomaly affecting more than 500 million people globally. In 2018, to highlight the importance of the immune system in the pathophysiology of osteoporosis, our group coined the term “immunoporosis”. In the present review, we exhaustively revisit the characteristics, mechanism of action, and function of both innate and adaptive immune cells with the goal of understanding the potential of immune cells in osteoporosis. We also highlight the Immunoporotic role of gut microbiota (GM) for the treatment and management of osteoporosis. Importantly, we further discuss whether an immune cell-based strategy to treat and manage osteoporosis is feasible and relevant in clinical settings.

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“…In addition, a study reported that treatment with FOS significantly enhanced bone health in Ovx rats by enhancing the butyrate levels in serum. 144 …”

Section: Harnessing the Immunoporotic Role Of Gut Microbiota (Gm)mentioning

confidence: 99%

The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis

Srivastava¹,

Sapra²

2022

JIR

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“…Before any surgery animals were anesthetized using xylazine (10 mg kg −1 ) and ketamine (40 mg kg −1 ) injection (intramuscular). 30,32,33 2.2.1 5/6 th nephrectomy (Nx) model of CKD. Forty adults (12-14 weeks) female SD rats (weight 200-230 g) were either sham-operated or Nx.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…The EchoMRITM-500 body composition analyzer (EchoMRI Corporation Pvt. Ltd, Singapore) was used to scan the experimental rats following our previously described method 29,30,33 to determine the fat mass and lean mass as percentages of body weight. The system was calibrated by scanning a known sample of canola oil and distilled water before any animals were scanned.…”

Section: Body Compositionmentioning

confidence: 99%

“…32 Finally, by using the Bioquant Osteo software, MS/BS, MAR and BFR were calculated using the respective formulas: MS/BS = (dLS + sLS/2)/BS × 100 (%), MAR = Ir.L.Th/10 days (μm per day), BFR = MAR × (MS/BS) (μm per day). 29,31,33,44,47,[49][50][51][52] Unmineralized osteoids were studied at the proximal femur by cutting 6 μm sections of undecalcified bones as described above. Goldner trichrome (GT) staining procedure was carried out according to the protocol available from Bioquant.…”

Section: Surface Referent Bone Formationmentioning

confidence: 99%

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Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function

et al. 2022

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“…Gut-derived SCFAs, especially butyrate and propionate, are the regulators of bone homeostasis, traveling to bone marrow and directly affecting bone metabolism. Fructo-oligosaccharide administration significantly increases serum level of butyrate and promotes bone formation in rats, ameliorating the pathological bone loss due to estrogen deficiency ( Porwal et al., 2020 ). Study by Lucas and colleagues directly demonstrated the translocation of SCFAs to bone tissue, as evidenced by augmented butyrate or propionate concentrations in bone marrow of the mice with exogenous supplement of corresponding SCFA in drinking water ( Lucas et al., 2018 ).…”

Section: Underlying Mechanisms Of Gut-alveolar Bone Axismentioning

confidence: 99%

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Jia

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health via regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.

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A prebiotic, short-chain fructo-oligosaccharides promotes peak bone mass and maintains bone mass in ovariectomized rats by an osteogenic mechanism

Cited by 27 publications

References 40 publications

The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis

The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis

Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

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