A preclinical evaluation of polypropylene/polylacticacid hybrid meshes for fascial defect repair using a rat abdominal hernia model

Abstract

ObjectivesSynthetic mesh surgery for both abdominal and urogenital hernia repair is often unsatisfactory in the long-term due to postoperative complications. We hypothesized that a semi-degradable mesh hybrid may provide more appropriate biocompatibility with comparable mechanical properties. The aim was to compare its in vivo biocompatibility with a commercial polypropylene (PP) mesh.Methods72 rats were randomly allocated to either our new composite mesh (monofilament PP mesh knitted with polylactic-acid-fibers (PLA)) or to a commercially available PP mesh that was used as a control. 15, 90, and 180 days after implantation into the rat abdomen mesh tissue complexes were analysed for erosion, contraction, foreign body reaction, tissue integration and biomechanical properties.ResultsNo differences were seen in regard to clinical parameters including erosion, contraction or infection rates between the two groups. Biomechanical properties including breaking load, stiffness and deformation did not show any significant differences between the different materials at any timepoint. Macrophage staining did not reveal any significant differences between the two groups or between timepoints either. In regard to collagen I there was significantly less collagen I in the PP group compared to the PP/ PLA group at day 180. Collagen III did not show any significant differences at any timepoint between the two groups.ConclusionA PP/PLA hybrid mesh, leaving a low amount of PP after PLA degradation seems to have comparable biomechanical properties like PP at 180 days due to enhanced collagen production without significant differences in erosion, contraction, herniation or infection rates.

Ascorbic Acid 2-Phosphate-Releasing Supercritical Carbon Dioxide-Foamed Poly(L-Lactide-Co-epsilon-Caprolactone) Scaffolds Support Urothelial Cell Growth and Enhance Human Adipose-Derived Stromal Cell Proliferation and Collagen Production

“…Increased amount of COL III may provide more elasticity for the forming tissue [98,99], but overproduction of COL III may contribute to the formation of fbrosis [99,100]. Decreased ratio of COL I/III in tissue has been identifed in fbrotic growth [101,102].…”

Implant system for treatment of the orbital floor defects of blowout fractures in the maxillofacial region using polypropylene yarn and bioactive bone cement

“…For antibacterial tests, a combination of five clinically isolated bacterial strains was used: Staphylococcus aureus , Staphylococcus epidermidis , Enterococcus faecalis , Enterobacter cloacae , and Pseudomonas aeruginosa (supplied by the Specialist Hospital in Kościerzyna, Poland). These strains of bacteria were selected for being the most common sources of craniofacial infections (Silkey, Ludtke, & Acharya, ; Ulrich et al, ). Each strain of bacteria was incubated separately and then added to a sterile 0.9% NaCl solution.…”

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

“…However, all biomaterials implantation will inevitably initiate the host FBR (3). This response to biomaterials can affect the performance of the implants during application, and even lead to a range of complications such as infection, chronic inflammation, tissue adhesion and chronic pain (4,5). Therefore, assessing the host FBR is still the most important field of research in biomaterials design and application.…”