1996
DOI: 10.1006/bbrc.1996.1148
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A Precursor of the Nitric Oxide Donor SIN-1 Modulates the Stress Protein Heme Oxygenase-1 in Rat Liver

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Cited by 55 publications
(27 citation statements)
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“…51,52 However, our results suggest that endogenous NO generated by preconditioning is not responsible for increased HSP. In fact, the mechanisms involved in the beneficial effects of the two sources of NO might well be different.…”
Section: 34contrasting
confidence: 51%
“…51,52 However, our results suggest that endogenous NO generated by preconditioning is not responsible for increased HSP. In fact, the mechanisms involved in the beneficial effects of the two sources of NO might well be different.…”
Section: 34contrasting
confidence: 51%
“…In agreement with this concept, we have previously reported that at the concentrations of SNP, SNAP, and SIN-1 used in our protocol (0.5-1 mM) no relevant cytotoxic effects to endothelial cells were detected (8). In addition, we observed that in vivo administration of a precursor of the NO releasing agent SIN-1 caused a rapid increase in hepatic HO-1 mRNA expression and activity, and this effect was not associated with overt damage to liver tissue (32). Other authors have reported that the cytotoxic activity of SIN-1, which mediates the formation of ONOO Ϫ , occurred in human epithelial cancer cells at high concentrations (5 mM) and only 48 h after incubation (47).…”
Section: Effect Of Various No Donors On Endothelial Hemesupporting
confidence: 51%
“…Where indicated, 100 l of the culture medium were reacted with an equal volume of Griess reagent (0.5% sulfanilamide, 0.05% N-(1-naphthyl)ethylenediamine dihydrochloride in 2.5% H 3 PO 4 ) in 96-well plates at room temperature for 10 min with shaking. The resulting azodye product was spectrophotometrically quantitated at 550 nm using a Dynatech MR 700 microplate reader, and nitrite levels were determined as described previously by comparison with standard curves made from a solution of sodium nitrite (32).…”
Section: Methodsmentioning
confidence: 99%
“…In addition to regulating vascular tone, it is now increasingly recognized that NO modulates a variety of important physiological activities related to vascular homeostasis, including platelet aggregation, leukocyte trafficking, cell signaling, and the migration and growth of endothelial and smooth muscle cells. NO donors 64 and pure, gaseous NO 65 induce HO-1. This induction is due, in part, to the increased stability of HO-1 mRNA 65 and extends to many different forms of NO (eg, NONOates, S-nitrosothiols, sodium nitroprusside, and pentaerythritol tetranitrate) and vascular cells.…”
Section: Response To Therapeutic Agentsmentioning
confidence: 99%