A predictive depression pattern in mild cognitive impairment

Houde, Michèle; Bergman, Howard; Whitehead, Victor; Chertkow, Howard

doi:10.1002/gps.2028

Cited by 45 publications

(36 citation statements)

References 21 publications

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“…This again suggests that MCI and mood are related and hints at the potential for a temporal element to the relationship, as the presence of MCI at baseline had an influence on the presence of depression at follow-up. However, mood problems at baseline were not associated with a change from no cognitive impairment to MCI, which reflects previous research (Panza et al, 2008;Steenland et al, 2012), or from MCI to dementia over the two year period, which again fits with some previous literature (Devier et al, 2009;Houde et al, 2008;Vicini Chilovi et al, 2009), but contrasts with other research findings (Gabryelewicz et al, 2007).…”

Section: Are MCI and Mood Problems Related?contrasting

confidence: 56%

“…Only one study found that a higher score on measures of depression was significantly more frequent in individuals who progress from MCI to dementia (Gabryelewicz et al, 2007). One study found that whilst there was no difference in the baseline levels of depressive symptoms between individuals who progressed to dementia and those who did not, the persistence of depressive symptoms increased risk of progression (Houde et al, 2008). A further study followed participants for 2.1 years and found that baseline NPI scores for depression were higher in those who progressed from MCI to dementia than in those who continued to be classified as having MCI, although this did not remain significant after correction for multiple…”

Section: Progression From MCI To Dementiamentioning

confidence: 99%

“…Research has shown that both the presence of symptoms of depression (Gabryelewicz et al, 2007) and the persistence of depressive symptoms (Houde, Bergman, Whitehead, & Chertkow, 2008) are related to increased risk of progression from MCI to dementia. However, a protective effect of depression on progression to dementia was also found (Vicini Chilovi et al, 2009).…”

Section: Relationship Between Mood and Cognitionmentioning

confidence: 99%

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The Relationship Between Mild Cognitive Impairment and Mood in Older People

Yates¹

2018

Preprint

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Mild cognitive impairment (MCI) has received increasing attention since the early 1990s. However, considerable controversy exists over exactly how the concept of MCI is defined and measured, and the implications of assigning or receiving a diagnosis of MCI. There is evidence of a link between MCI and mood, but empirical work remains conflicted and inconclusive. The first chapter provides an overview of the MCI concept and highlights some of the issues surrounding its definition. Chapter 2 provides a detailed description of the methodology and background to the empirical work presented in Chapters 4-6. A systematic review of the literature forms the third chapter of this thesis and establishes the need for further study into the relationship between MCI and mood. Chapter 4 makes use of data from the first Cognitive Function and Ageing Study (MRC-CFAS I) to investigate the role of subjective memory complaints (SMC) in the relationship between MCI and mood over a two year period. The results indicated that SMC may be related more strongly to mood than to objective cognitive performance, which raises questions about whether SMC should be included as a criterion in the MCI definition. Chapter 5 clarifies these findings using data from a contemporary cohort in the Cognitive Function and Ageing Study Wales (CFAS Wales). Chapter 6 investigates the role of health in the relationship between MCI and mood, again using data from CFAS Wales. The findings suggest that health problems constitute a risk factor for developing depression and anxiety, which may in turn affect cognitive functioning. This presents a useful opportunity for intervention to improve the quality of life for older people by improving their physical health, or improving the management of long-term conditions. Social networks were investigated as an influential factor in the relationship between MCI and mood, using data from CFAS Wales. Whilst increases in social network size were associated with fewer mood problems and increased cognitive functioning, they did not moderate the relationship between the two. However, this finding still showed that having more social contacts is beneficial and important to the quality of life of older people. The last chapter presents a discussion of the findings in relation to each of the research questions outlined in Chapter 1. The chapter also includes a commentary on the methodological considerations that were faced when developing this thesis, the implications of the findings and directions for future research.

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Section: Are MCI and Mood Problems Related?contrasting

confidence: 56%

Section: Progression From MCI To Dementiamentioning

confidence: 99%

Section: Relationship Between Mood and Cognitionmentioning

confidence: 99%

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The Relationship Between Mild Cognitive Impairment and Mood in Older People

Yates¹

2018

Preprint

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“…Houde and colleagues [33] reported that the simple presence or absence of depression at referral did not predict progression from MCI to AD in 60 patients with A-MCI who were observed annually for an average of 4.3 years. However, positive answers to specifi c GDS questions that referred to "melancholic" affect and the persistence of depression over 2 to 3 years signifi cantly predicted cognitive deterioration that eventually led to AD.…”

Section: Patients With Depressive Symptoms: Clinical Characteristmentioning

confidence: 98%

Psychological distress and risk for dementia

Simard

Hudon²,

Reekum³

2009

Curr Psychiatry Rep

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The concept of mild cognitive impairment (MCI) primarily emphasizes changes in individuals' mental abilities, but it has recently been suggested that neuropsychiatric symptoms should also be considered important factors in age-related neurodegeneration. Psychological distress, defined as a reaction of an individual to external and internal stresses, is characterized by a mixture of psychological symptoms. It also may be considered a neuropsychiatric symptom encompassing depression, anxiety, and apathy. This paper reviews and summarizes recent evidence and relevant issues regarding the presence of psychological distress in healthy older adults and MCI patients and its relationship to risk for developing dementia. Results presented in this review show that psychological distress and depressive, anxious, and apathetic symptoms can be present in MCI and may predict progression to dementia. This article also provides suggestions for future research.

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“…Depression has been identified as a risk factor for the development of Alzheimer's disease [1], as a factor in the conversion of MCI to AD [2], and as a disorder affecting a significant number of individuals with AD [3]. The underlying biological mechanisms linking depression and AD are unclear.…”

Section: Introductionmentioning

confidence: 99%