2016
DOI: 10.1371/journal.pcbi.1004795
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A Predictive Model for Yeast Cell Polarization in Pheromone Gradients

Abstract: Budding yeast cells exist in two mating types, a and α, which use peptide pheromones to communicate with each other during mating. Mating depends on the ability of cells to polarize up pheromone gradients, but cells also respond to spatially uniform fields of pheromone by polarizing along a single axis. We used quantitative measurements of the response of a cells to α-factor to produce a predictive model of yeast polarization towards a pheromone gradient. We found that cells make a sharp transition between bud… Show more

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Cited by 23 publications
(36 citation statements)
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References 68 publications
(76 reference statements)
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“…Proof. Consider a sequence (D k ) k with D k → ∞ as k → ∞ and let (u k , v k , w k ) be a solution to (17)- (21) with D replaced by D k . By the bound (22) and standard compactness arguments we deduce the existence of a subsequence (not relabeled)…”
Section: Passage To the Limit D → ∞mentioning
confidence: 99%
See 2 more Smart Citations
“…Proof. Consider a sequence (D k ) k with D k → ∞ as k → ∞ and let (u k , v k , w k ) be a solution to (17)- (21) with D replaced by D k . By the bound (22) and standard compactness arguments we deduce the existence of a subsequence (not relabeled)…”
Section: Passage To the Limit D → ∞mentioning
confidence: 99%
“…For finite D we use a similar rescaling of the steady-state equation (17)- (21) as in the previous section but consider in addition to (26) that D becomes large with ε → 0, more precisely D 1 ε D with D of order one. This yields the following bulk-surface system.…”
Section: Derivation Of a Nonlocal Obstacle Problemmentioning
confidence: 99%
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“…Receptor activation restricts polarised assembly movement [28] and thus, high local levels of chemoattractant positively regulate polarity axis stability. At least in yeast, the concentration range capable of gradient sensing is very narrow [56]. Polarity axis stability is thus a product of local concentration sampling by the polarised assembly and global concentration integration through Cdc24-sequestration (Fig.…”
Section: Local Sampling Versus Global Inhibitory Signalling à a Modelmentioning
confidence: 99%
“…The globally integrated chemoattractant concentration sets the level of polarity axis stability. At least in yeast, the concentration range capable of gradient sensing is very narrow [56]. The integrated signal will not change dramatically in response to small fluctuations of chemoattractant.…”
Section: Local Sampling Versus Global Inhibitory Signalling à a Modelmentioning
confidence: 99%