A predictive model integrating deep and radiomics features based on gadobenate dimeglumine-enhanced MRI for postoperative early recurrence of hepatocellular carcinoma

Gao, Wenyu; Wang, Wentao; Song, Danjun; Yang, Chun; Zhu, Kai; Zeng, Mengsu; Rao, Shengxiang; Wang, Manning

doi:10.1007/s11547-021-01445-6

Cited by 37 publications

(27 citation statements)

References 32 publications

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“…With such techniques, it is also possible to derive information directly from the images on the molecular and genomic characteristics of the tumor (radiogenomics) with the ultimate intent of extracting indications on aggressiveness, prognosis, and therapeutic response [ 77 , 133 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 ].…”

Section: Precision Medicine: Radiomics and Radiogenomics—the New Fron...mentioning

confidence: 99%

Gender Medicine in Clinical Radiology Practice

Giacobbe

Granata

Trovato

et al. 2023

JPM

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Gender Medicine is rapidly emerging as a branch of medicine that studies how many diseases common to men and women differ in terms of prevention, clinical manifestations, diagnostic-therapeutic approach, prognosis, and psychological and social impact. Nowadays, the presentation and identification of many pathological conditions pose unique diagnostic challenges. However, women have always been paradoxically underestimated in epidemiological studies, drug trials, as well as clinical trials, so many clinical conditions affecting the female population are often underestimated and/or delayed and may result in inadequate clinical management. Knowing and valuing these differences in healthcare, thus taking into account individual variability, will make it possible to ensure that each individual receives the best care through the personalization of therapies, the guarantee of diagnostic-therapeutic pathways declined according to gender, as well as through the promotion of gender-specific prevention initiatives. This article aims to assess potential gender differences in clinical-radiological practice extracted from the literature and their impact on health and healthcare. Indeed, in this context, radiomics and radiogenomics are rapidly emerging as new frontiers of imaging in precision medicine. The development of clinical practice support tools supported by artificial intelligence allows through quantitative analysis to characterize tissues noninvasively with the ultimate goal of extracting directly from images indications of disease aggressiveness, prognosis, and therapeutic response. The integration of quantitative data with gene expression and patient clinical data, with the help of structured reporting as well, will in the near future give rise to decision support models for clinical practice that will hopefully improve diagnostic accuracy and prognostic power as well as ensure a more advanced level of precision medicine.

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Section: Precision Medicine: Radiomics and Radiogenomics—the New Fron...mentioning

confidence: 99%

Gender Medicine in Clinical Radiology Practice

Giacobbe

Granata

Trovato

et al. 2023

JPM

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“…This tissue should be correctly distinguished from new lesions, expressions of disease recurrence [ 140 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 ]. On US assessment, scar tissue is iso-hyperecoic without contrast enhancement during CEUS evaluation [ 140 ].…”

Section: Non Anatomic Liver Resectionmentioning

confidence: 99%

Imaging Features of Main Hepatic Resections: The Radiologist Challenging

Cutolo

Fusco

Simonetti

et al. 2023

JPM

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Liver resection is still the most effective treatment of primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), and of metastatic disease, such as colorectal liver metastases. The type of liver resection (anatomic versus non anatomic resection) depends on different features, mainly on the type of malignancy (primary liver neoplasm versus metastatic lesion), size of tumor, its relation with blood and biliary vessels, and the volume of future liver remnant (FLT). Imaging plays a critical role in postoperative assessment, offering the possibility to recognize normal postoperative findings and potential complications. Ultrasonography (US) is the first-line diagnostic tool to use in post-surgical phase. However, computed tomography (CT), due to its comprehensive assessment, allows for a more accurate evaluation and more normal findings than the possible postoperative complications. Magnetic resonance imaging (MRI) with cholangiopancreatography (MRCP) and/or hepatospecific contrast agents remains the best tool for bile duct injuries diagnosis and for ischemic cholangitis evaluation. Consequently, radiologists should be familiar with the surgical approaches for a better comprehension of normal postoperative findings and of postoperative complications.

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“…By tapping the computational power of artificial intelligence (AI) systems, a large amount of information that go beyond visual image assessment can be collected through the extraction and analysis of radiomics features from medical images, obtained in a routine setting with conventional imaging protocols (e.g., for tumor staging and follow-up). This approach has the potential to enhance options to carry out patient-specific diagnostic and prognostic evaluations, allowing e.g., to predict early treatment response and avoid undue over- or undertreatment depending on the biological aggressiveness of each patient-specific disease, and paving the way to a more individualized patient management [ 22 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ]. Other advantages of radiomics over conventional biopsy include the possibility to capture the tumor tissue in its entirety (providing information regarding its clonal heterogeneity and the tumor microenvironment along with its stromal component), to guide biopsy towards specific tumor areas, and to be repeatable at virtually any time during the disease course, allowing longitudinal monitoring with improved opportunities of optimizing treatment strategies [ 39 , 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Radiomics in Lung Metastases: A Systematic Review

Gabelloni

Faggioni

Fusco

et al. 2023

JPM

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Due to the rich vascularization and lymphatic drainage of the pulmonary tissue, lung metastases (LM) are not uncommon in patients with cancer. Radiomics is an active research field aimed at the extraction of quantitative data from diagnostic images, which can serve as useful imaging biomarkers for a more effective, personalized patient care. Our purpose is to illustrate the current applications, strengths and weaknesses of radiomics for lesion characterization, treatment planning and prognostic assessment in patients with LM, based on a systematic review of the literature.

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A predictive model integrating deep and radiomics features based on gadobenate dimeglumine-enhanced MRI for postoperative early recurrence of hepatocellular carcinoma

Cited by 37 publications

References 32 publications

Gender Medicine in Clinical Radiology Practice

Gender Medicine in Clinical Radiology Practice

Imaging Features of Main Hepatic Resections: The Radiologist Challenging

Radiomics in Lung Metastases: A Systematic Review

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