A Predictive Model of In‐Hospital Mortality in Elderly Patients Admitted to Medical Intensive Care Units

Bo, Mario; Raspo, Silvio; Massaia, Massimiliano; Cena, Paola; Bosco, Francesca; Fabris, F.; Antro, C; Gai, AP Valerio

doi:10.1046/j.1532-5415.2003.514844.x

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…There is evidence that weight loss occurs a few year prior to clinical diagnoses of dementia. Weight loss is associated with greater mortality among AD patients [13] as well as those without dementia [14] . The effect of AD, and subclinical dementia on weight loss presents a challenge in being able to evaluate the role of adiposity in development of dementia on AD.…”

Section: Weight Change and Dementiamentioning

confidence: 99%

The Epidemiology of Adiposity and Dementia

Whitmer

2007

CAR

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Adipose tissue is the largest endocrine gland in the body, yet only recently has its role in neurodegenerative disease been considered. Prospective population level evidence has emerged to show that both obesity and overweight, is associated with an increased risk of all cause dementia, Alzheimer's disease (AD), and underlying neurodegenerative changes. Weight loss in late life however is associated with dementia, and those categorized as underweight are also at a greater risk of dementia. Given the current epidemic of obesity, and the expected age-related increase in dementia incidence, even a small association between these two diseases has far reaching public health implications. However, due to the effects of both AD-associated weight loss and age-related changes in body composition, there are methodological challenges in appropriately evaluating obesity as a risk factor for developing dementia. There is a need to take a 'life course approach' and to consider the role of risk factors prior to the onset of old age. Our work has shown that both obesity and overweight, as measured by body mass index and skinfold thickness, in middle-age are strongly associated with an increased risk of all cause dementia, Alzheimer disease & Vascular dementia, independent of the development of diabetes and cardiovascular-related morbidities. There is also value in assessing regional body shape distributions of adiposity, particular the role of abdominal obesity. Mechanistic pathways such as adipocyte secreted proteins and hormones, and inflammatory cytokines could explain the association between obesity and increased risk of dementia.

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Section: Weight Change and Dementiamentioning

confidence: 99%

The Epidemiology of Adiposity and Dementia

Whitmer

2007

CAR

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“…Chiavone PA ve arkadaşlarının yaptığı çalışmada APACHE-II değeri arttıkça mortalite oranının arttığı gösterildi (18,19). Çalışmamızda ise APACHE-II skoru ile mortalite arasında istatistiksel olarak anlamlı bir ilişki saptanmadı.…”

Section: Discussionunclassified

The Relationship Between Inflammatory Reagents and Mortality in Patients Over the Age of 55 Hospitalised in the Internal Medicine Intensive Care Unit from the Emergency Service

Uluoz¹,

Sebe²,

Ay³

et al. 2013

JAEM

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Objective: In this study, we tried to determine the relationship between inflammatory reagents, acute phase reactants, GCS, APACHE-II, SAPS-II scores and mortality of the patients over the age of 55 hospitalised inthe internal medicine intensive care unit. Material and Methods: This study was planned as a prospective, randomized study and the patients hospitalized in the intensive care unit from the emergency medicine department were enrolled in this study following the ethics committee approval. A standard data collection form was prpeared to collect the data in a standard way. 48 (%65.8) male, 25 (%34.2) women and a total of 73 patients were included in our study. Blood samples were taken from each patient and white blood cell (WBC), hemoglobin, c-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), prothrombin time (PTZ), activated partial thromboplastin time (aPTT), albumin and ferritin levels were studied in our laboratory. Glasgow Coma Scale, SAPS-II and APACHE-II scores were calculated for each patient. "SPSS for Windows version 18" package program was used for statistical analysis of the data. Chi square test was used to compare categorical measures between the groups. Mann-Whitney U test and T-test were used to compare quantitative measurements between the groups. Results: There was no statistically significant difference in mean age among patients who died and survived . Mean duration of hospitalization inthe patient group who died was less than for the survived patients group but there was no statistically significant difference between groups. A significant relationship was found between mortality and the high levels of ferritin, aPTT, SAPS-II and the low levels of albümin, GCS. No significant relationship was found between mortality and leukocyte count, haemoglobin, PTZ, CRP, TNFalpha, IL-1, IL-6, IL-10 and APACHE-II score. Conclusion: SAPS-II, GCS, ferritin, albumin, aPTT measurements were determined to be used in the mortality estimation of the patients hospitalised in the intensive care unit. (JAEM 2013; 12: 13-8)

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“…Inadequate food intake is the cause of malnutrition while physical and cognitive limitations can prevent adequate food intake (25). Cereda et al, 2008 (23), showed that poorer functional status was associated with low BMI, sarcopenia and reduced oral intake and the MNA reliably identifies at-risk institutionalized elderly needing higher standards of care, particularly related to eating.…”

Section: Discussionmentioning

confidence: 99%