A Predictive Model of Metabolic Syndrome by Medical Examination: Evidence from an 8-Year Chinese Cohort

Guo, Huanyu; Jiang, Weihang; Zhao, Bo; Xiong, Yanhua; Lu, Zhen-Ya

doi:10.2147/dmso.s314550

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…30 According to Gu H et al, the risk of MetS in overweight, pre-hypertension, hypertension subjects were OR = 4.610, CI 95% [2.415 to 8.800], OR = 2.759, CI 95% [1.519 to 5.011] and OR = 3.589, CI 95% [1.672 to 7.706] times higher than that in controls, respectively. 34 Other multivariate logistic analyses, confirm that the visceral obesity OR = 6.54; CI 95% [2.99-14.3], low HDL-C Some limits of our study are that our data did not include information on the treatment status of hypertension. Also, the hygienic and dietetic behaviors were not evaluated that could be confounding factors in our series.…”

Section: Discussionmentioning

confidence: 59%

Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali

Coulibaly¹,

Kondé²,

Traoré³

et al. 2023

IJCBR

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Blood cardiometabolic impairments are associated to high blood pressure which is a pivot cardiovascular risk factor. The objective of this study was to assess cardiometabolic risk factors rates in subjects with high blood pressure in the steady state. A total of 292subjects, 107 cases and 185 controls were enrolled in cross-sectional study. Clinical and biological data were assessed during visits and after overnight fasting. Data were analyzed on R. A p-value < 0.05 was considered for statistical significance.Univariate analysis showed thatage > 50 years, visceral obesity, metabolic syndrome and hs- CRP ≥ 3 mg/L were significant predictors of high blood pressure: OR = 2.1, 95% CI [1.3-3.5], p = 0.003; OR = 1.6, 95% CI [1.0-2.6], p = 0.05; OR = 3.3; 95% CI [2.0-5.4], p < 0.001; OR = 16.8; 95% CI [9.4-31.4], p < 0.001, respectively. Multivariate analysis showed a positive association between obesity, metabolic syndrome, hs-CRP and high blood pressure: aOR = 2.29; 95% CI [1.14-4.69], p = 0.02; aOR = 3.47; 95% CI [1.64-7.61], p = 0.001; aOR = 18.10; CI, 2.5% to 95% [9.40-36.99], p < 0.001, respectively. In contrast, female sex was negatively associated with high blood pressure aOR = 0.31; CI, 95% CI [0.13-0.72], p < 0.008. Prevention policiesshould take into account blood cardiometabolic level for subjects with high blood pressure even though in the steady sate.

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Section: Discussionmentioning

confidence: 59%

Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali

Coulibaly¹,

Kondé²,

Traoré³

et al. 2023

IJCBR

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“…Our data suggest that presence of SRCs, even with incidental finding, might require a further survey of potential metabolic syndrome. Although there have been some predictive models of metabolic syndrome ( 55 – 57 ), clinical application of SRCs in the risk stratification needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Association of simple renal cysts with metabolic syndrome in adults

Shen

Sun²,

Chou³

et al. 2022

Front. Public Health

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Background and aimsMetabolic syndrome is common nowadays and may increase risk of hypertension, type 2 diabetes mellitus, cardiovascular complications and even mortality. Renal cysts are also frequently found during routine examination. However, the relationship between simple renal cysts (SRCs) and metabolic syndrome remains unclear. This study aimed to investigate the association of SRCs with metabolic syndrome.MethodsA total of 16,216 subjects aged ≥18 years were enrolled in this study. SRCs were diagnosed with ultrasonography by finding: sharp, thin posterior walls, a round/oval shape, absence of internal echoes, and posterior enhancement. SRCs were categorized by number (0, 1, and ≥2) and size (<2 and ≥2 cm). Metabolic syndrome was diagnosed according to the consensus statement from the International Diabetes Federation.ResultsIn multivariate analysis, SRCs were positively related to metabolic syndrome (OR: 1.18, 95% CI: 1.06–1.34). The risk of metabolic syndrome was higher for SRCs with a number ≥2 (OR: 1.35, 95% CI: 1.08–1.68) and size ≥2 cm (OR: 1.33, 95% CI: 1.10–1.61). When considering the SRC number and size concomitantly, SRCs with a number ≥2/size ≥2 cm (OR: 1.42, 95% CI: 1.02–1.98) or <2/size ≥2 cm (OR: 1.30, 95% CI: 1.04–1.62) were positively related to metabolic syndrome.ConclusionsSimple renal cysts were found to be related to a higher risk of metabolic syndrome, and the association is more significant in those with larger (sizes ≥2cm) or plural (numbers ≥2) SRCs.

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“…Low HDL-C is associated with insulin resistance and high risk of MetS. 44 Compared to the individuals with high amylase activity, those with low amylase activity had lower levels of long- and medium-chain fatty acids and higher levels of dicarboxylic fatty acids and 2-hydroxybutyrate, 45 which is an established biomarker of glucose malabsorption and insulin resistance. 46 Insulin resistance could increase the synthesis and secretion of very-low-density lipoprotein (VLDL) and TG in the liver, and reduce clearance, resulting in hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults

Zhan¹,

Chen²,

H³

et al. 2021

DMSO

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Purpose: Low serum amylase activity and copy number (CN) variation (CNV) of the salivary amylase gene (AMY1) are reportedly associated with obesity and abnormal glucose metabolism; however, this association remains controversial. We aimed to clarify the relationship between serum amylase activity and the CNV of AMY1/2A/2B with the occurrence of metabolic syndrome (MetS) in Chinese adults. Patients and Methods: Anthropometry, metabolic risk factors, and serum amylase activity were assessed in 560 subjects (260 MetS patients; 300 healthy controls). AMY1/2A/2B CNs were evaluated using the highly sensitive droplet digital PCR. Results: The serum total, pancreatic, and salivary amylase activity, but not the AMY1/2A/2B CNs, was significantly lower in MetS patients than that in the control subjects. Patients <45 y had a lower AMY1 CN, compared to that in healthy controls. Low serum amylase activity was significantly associated with high MetS prevalence (p < 0.001). In the receiver operating characteristic curve analysis, serum amylase activity was a significant diagnostic indicator for MetS. The diagnostic value of total amylase was second only to that of γ-glutamyl transpeptidase; it was higher than that of alanine aminotransferase and uric acid. Conclusion: Low serum amylase activity was significantly associated with increased risk of MetS in Chinese adults. Therefore, amylase could be a potential biomarker for predicting MetS.

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A Predictive Model of Metabolic Syndrome by Medical Examination: Evidence from an 8-Year Chinese Cohort

Cited by 5 publications

References 34 publications

Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali

Effects of cardiometabolic risk factors on blood pressure in outpatients at Sominé DOLO hospital, Mopti, Mali

Association of simple renal cysts with metabolic syndrome in adults

Association of Serum Amylase Activity and the Copy Number Variation of AMY1/2A/2B with Metabolic Syndrome in Chinese Adults

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