2021
DOI: 10.1016/j.jid.2021.02.012
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A Predictive Self-Organizing Multicellular Computational Model of Infant Skin Permeability to Topically Applied Substances

Abstract: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, a… Show more

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Cited by 8 publications
(13 citation statements)
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“…The middle of the ventral side of volar forearm was chosen for the measurements. The results obtained using the computational model compared very well with the experimental data [160]. This technique clearly has potential for evaluation of chemical permeation following repeated use of baby wipes and other infant skin care products.…”
Section: Challenges and Opportunitiessupporting
confidence: 53%
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“…The middle of the ventral side of volar forearm was chosen for the measurements. The results obtained using the computational model compared very well with the experimental data [160]. This technique clearly has potential for evaluation of chemical permeation following repeated use of baby wipes and other infant skin care products.…”
Section: Challenges and Opportunitiessupporting
confidence: 53%
“…The authors used CRS to measure skin hydration and NMF concentrations in infants. Recently, Stamatas et al (2021) proposed a computational model for estimation of permeation of actives in infant skin [160]. Briefly, skin permeation of a marker compound (caffeine) in infants and adults was determined using CRS.…”
Section: Challenges and Opportunitiesmentioning
confidence: 99%
“…This model builds on a previously presented model that considers explicitly keratinocyte proliferation, differentiation and desquamation processes and can recapitulate skin structure, water barrier function and penetration kinetics of an external substance introduced at the skin surface at a given time of the simulation. 13 This model is modified here by the introduction of KLK production, auto-activation (KLK*) and inhibition by LEKTI, processes which affect the rate of corneocyte desquamation at the skin surface. 20,21 The mathematical model first described by Tanaka et al 10 is adapted and integrated at the agent-level programming of the corneocytes, present only in the SC.…”
Section: Model Overviewmentioning
confidence: 99%
“…The agent-based model also allows for the simulation of permeation of a topically applied substance, as described by Stamatas et al 13 Here, we consider that the externally applied substance is an irritant, which can trigger skin inflammation depending on its . 15 (II) KLK and its inhibitor, LEKTI are released at the interface of SG and SC and interact in the SC.…”
Section: Model Overviewmentioning
confidence: 99%
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