A pregnancy complication-dependent change in SIgA-targeted microbiota during third trimester

Cui, Mengjun; Cui, Qi; Yang, Liping; Zhang, Mengyun; Wang, Huiyan; She, Guangtong; Yu, Renqiang; Miao, Tingting; Sun, Jin

doi:10.1039/c9fo02919b

Cited by 25 publications

(36 citation statements)

References 51 publications

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“…In the following months, the variability of microorganisms decreases, and there is an increase in the populations of Proteobacteria and Actinobacteria; Bifidobacteria belong to the latter and play a pivotal role in the defense against pathogenic bacteria, in strengthening the intestinal barrier, and in the nutrients' metabolism. The intestine of a pregnant woman can become more permeable favoring the so-called "bacterial translocation" so that the fetus can come into contact with microorganisms of maternal origin (microbes have been found in the blood of the umbilical cord, in the amniotic fluid, and even in the meconium) (102)(103)(104). Furthermore, according to the most widespread theories, the baby's intestine is colonized during childbirth by the bacteria of the maternal microbiota.…”

Section: Expert Opinionmentioning

confidence: 99%

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Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

et al. 2020

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Polycystic ovary syndrome (PCOS) is a very common endocrine and metabolic disorder with the involvement of both genetic and environmental factors. Although much has been clarified on its pathogenesis, diagnosis, clinical manifestations, and therapy, there are still areas of uncertainty. To address fundamental concepts, novel aspects and hypotheses, and future perspectives, including the possible additional benefits of treatment with nutraceuticals, an expert consensus panel formed by endocrinologists and gynecologists was established. After an independent review of the literature, the panel convened electronically on February 3, 2020, and six resolutions were created, debated, and agreed upon discussion, and finally approved in their final form in a consensus livestream meeting held on April 15. The summary of the resolutions are: (1) PCOS is a well-established medical condition that negatively affects reproduction, general health, sexual health, and quality of life; (2) the symptoms and signs of PCOS appear early in life especially in female newborns from PCOS carriers; (3) women with PCOS have significantly increased risk of pregnancy-related complications including gestational diabetes mellitus; (4) a male PCOS equivalent exists, and it may impact on metabolic health and probably on reproduction; (5) the evidence supports that medical therapy for PCOS is effective, rational, and evidence-based; (6) the evidence supports a major research initiative to explore possible benefits of nutraceutical therapy for PCOS. The proposed resolutions may be regarded as points of agreement based on the current scientific evidence available.

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Section: Expert Opinionmentioning

confidence: 99%

“…This imbalance can also lead to a greater absorption of calories with a consequent weight increase of the pregnant woman and a greater risk of developing GDM. Even the newborn could more easily develop childhood diabetes, allergies, and childhood obesity (102)(103)(104).…”

Section: Expert Opinionmentioning

confidence: 99%

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

et al. 2020

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“…We also found that maternal faeces, breastmilk, and infant faeces shared several species of sIgA-coated bacteria including Bi dobacterium, Enterococcus, Streptococcus, Lactobacillus, Klebsiella, Escherichia-Shigella. We previously found that Bi dobacterium, Enterococcus, and Lactobacillus also belonged to the dominant genus in sIgA-coated microbiota of healthy late pregnant women [33]. In addition, although Staphylococcus is the shared bacterium of sIgA-coated microbiota in breast milk and baby faeces, it is not the dominant bacterium of in maternal faeces, which indicates that the species origin is the skin.…”

Section: Discussionmentioning

confidence: 94%

“…Dominant species were L. reuteri and L. gasseri, which are commonly isolated from breast milk [40][41]. We recently found that L. reuteri is a typical species in the sIgA-coated bacterial fraction of healthy pregnant women [33]. The occurrence of L. reuteri in breast milk was higher in breast milk samples from rural and pastoral areas of China than in those from the industrialised region [33].…”

Section: Discussionmentioning

confidence: 99%

“…We recently found that L. reuteri is a typical species in the sIgA-coated bacterial fraction of healthy pregnant women [33]. The occurrence of L. reuteri in breast milk was higher in breast milk samples from rural and pastoral areas of China than in those from the industrialised region [33]. Strains isolated from the sIgA-targeted fraction of the former improved intestinal epithelial barrier function in mice [42].…”

Section: Discussionmentioning

confidence: 99%

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Co-occurence of Secretory Immunoglobulin A-Coated Bacteria in Maternal Gut, Breast Milk, and Infant Gut in Humans

Cui

Ding

Xiao

et al. 2021

Preprint

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BackgroundGut microbiota promote and maintain infant health. Vertical transmission of bacteria from the maternal gut through breast milk to an infant is an important source of microbial colonisation in human offspring. However, the causative active/culturable bacteria and mechanisms responsible for their mother-neonate vertical transfer via breastfeeding remain unclear. Secretory immunoglobulin A (sIgA) may mediate this vertical transmission; however, evidence supporting this hypothesis is required. In this study, we aimed to investigate whether sIgA-coated bacteria in the maternal intestine may migrate to breast milk and colonise the infant gut.ResultsMaternal faeces, breast milk, and neonatal faeces were collected from 19 mother-infant dyads during lactation stages specific to colostrum, transitional, and mature milk. sIgA-coated bacteria were enriched using magnetic-activated cell sorting, and live bacteria were cultured in lactic acid bacteria- and gut bacteria-specific medium. 16S ribosomal RNA gene amplicon sequencing showed that microbiota diversity in maternal faeces, breast milk, and infant faeces decreased sequentially from colostrum to transitional milk to mature milk. Significant beta diversity existed between sample types (p < 0.05). However, high similarity was found between sIgA-coated microbiota of the three types of samples at the mature milk stage. Source track analysis showed that sIgA-coated microbiota in breast milk and maternal gut are major contributors of sIgA-coated microbiota in infant gut. Genera with co-occurrence in sample types included Bifidobacterium, Enterococcus, Streptococcus, Lactobacillus, Klebsiella, Escherichia-Shigella, and an unclassified genus of Enterobacteriaceae. Shotgun sequencing of three dyads identified co-occurring species Lactobacillus and Bifidobacterium, including Lactobacillus salivarius, Lactobacillus reuteri, Lactobacillus gasseri, Lactobacillus jonsonii, Lactobacillus oris, Bifidobacterium longum, and Bifidobacterium breve. ConclusionsBreastmilk and infant faeces samples showed unique microbial composition and diversity in the three lactation stages. The fractions of sIgA-coated microbiota in maternal faeces, breast milk, and infant gut showed similar bacterial abundance patterns. This study will facilitate development of strategies to adjust aberrant microbial establishment and reduce the risk of disease by providing essential information for effective probiotic administration to the neonate and/or breastfeeding mother.

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Prevention of Atopic Dermatitis in Mice by Lactobacillus Reuteri Fn041 Through Induction of Regulatory T Cells and Modulation of the Gut Microbiota

Zhao

Cui

et al. 2022

Molecular Nutrition Food Res

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Scope: The development of atopic dermatitis (AD) in infants is closely related to the lagging development of intestinal microbiota, including that inoculated by breast milk bacteria, and immune development. Lactobacillus reuteri Fn041 is a secretory immunoglobulin A (sIgA) -coated bacterium derived from human milk. Methods and Results: We intervene with L. reuteri Fn041 in maternal and offspring BALB/C mice during late gestation and lactation and after weaning of the pups, respectively. AD is then induced with MC903. L. reuteri Fn041 significantly suppresses AD symptoms such as skin swelling, mast cell, and eosinophil infiltration. This effect is attributed to the regulation of the systemic Th1 and Th2 cytokine ratios and the promotion of CD4 + CD25 + Foxp3 + regulatory T cell proliferation in mesenteric lymph nodes. It is also associated with the regulation of intestinal microbiota, particularly promoting Lactobacillus and Akkermansia. Conclusion: Our study strengthens the understanding that breast milk-derived sIgA coated potential probiotics are involved in the development of infant intestinal microbiota, thus promoting immune development and preventing allergic diseases, and expanding the knowledge of breast milk sIgA and bacterial interactions on infant immune development.

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A pregnancy complication-dependent change in SIgA-targeted microbiota during third trimester

Abstract: Complications in the third trimester were related to disorders of the intestinal SIgA-targeted microbiota.

Cited by 25 publications

References 51 publications

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Co-occurence of Secretory Immunoglobulin A-Coated Bacteria in Maternal Gut, Breast Milk, and Infant Gut in Humans

Prevention of Atopic Dermatitis in Mice by Lactobacillus Reuteri Fn041 Through Induction of Regulatory T Cells and Modulation of the Gut Microbiota

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