A pregnancy-specific β1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene

Oikawa, Shinzo; Inuzuka, Chikako; Kuroki, Masahide; Matsuoka, Yuji; Kōsaki, Goro; Nakazato, Hiroshi

doi:10.1016/0006-291x(89)92324-3

Cited by 39 publications

(14 citation statements)

References 26 publications

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“…The human CEA family, recognized by CD66 and CD67 antibodies, consists of two major subfamilies, one termed the CEA subgroup, containing CEA, NCA, biliary glycoprotein (41), CGM1 (CGM1a, CGM1b, and CGM1c) (24,42), CGM2, CGM6, and CGM7 (CGM ϭ CEA gene family member). The second subfamily consists of the pregnancy-specific glycoproteins (43)(44)(45).…”

Section: Microbiology: Chen and Gotschlichmentioning

confidence: 99%

CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins

Chen

Gotschlich

1996

Proc. Natl. Acad. Sci. U.S.A.

160

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Section: Microbiology: Chen and Gotschlichmentioning

confidence: 99%

CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins

Chen

Gotschlich

1996

Proc. Natl. Acad. Sci. U.S.A.

160

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“…This PS/G species contains the Arg-Gly-Asp tripeptide (amino acids 126-128) in a position similar to that found in some other PSPG species (13,14,17,19,22). This tripeptide is also present in the well known cellular adhesion molecule N-CAM and in other proteins that are known to be important in the cellular recognition process (27,33).…”

mentioning

confidence: 89%

“…Moreover, near-full-length cDNAs encoding members ofthe PSf3G family were isolated and characterized by our laboratory (11,12) as well as by others (13)(14)(15)(16)(17)(18)(19)(20). Two gene fragments that share strong sequence similarity with the reported PSfG cDNAs have been reported (21,22). We now report the structural organization of a genomic clone that contains two linked PS(3G genes.…”

mentioning

confidence: 96%

“…27), within the immunoglobulin superfamily contain the surface active tripeptide Arg-GlyAsp, which acts in cell-surface recognition. Many members of the PSI3G gene family (including PSGGB in this study) are closely related to N-CAM and encode proteins that contain the Arg-Gly-Asp tripeptide (13,14,17,19,22). In this paper, we explore the possibility that the PSGGB-encoded protein may be involved in the genesis of gestational trophoblastic disease by acting as an adhesion molecule.…”

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confidence: 99%

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Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.

Leslie

Watanabe

Lei

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

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A genomic clone containing two linked human pregnancy-specific (31-glycoprotein (PSI3G) genes has been isolated and characterized. The two genes are arranged in the same 5' -+ 3' orientation; the 3' region (including the A2and B-C exons) of the upstream gene, PSGGA, is linked to the 5' region (including the 5'/L and L/N exons) of PSGGB, the downstream gene. Depending upon the domains compared, PSGGA and PSGGB share 92-98% nucleotide and 86-95%

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“…Sequence comparison allows division into two subgroups: the CEA subgroup members encode mainly membrane-bound molecules, whereas the PSG-subgroup encodes secreted proteins (reviewed in Thompson et al, 1991). The expression pattern of human PSG genes has been determined a t the mRNA level by Northern analyses, cDNA cloning, and reverse transcriptase-polymerase chain reaction [RT-PCRI (Oikawa et al, 1989;Barnett et al, 1990;Thompson et al, 1990;Streydio and Vassart, 1990). These studies confirm the main site of expression to be the placenta, although PSG transcripts have also been found in salivary glands (Zoubir et al, 1990) and fetal liver Khan et al, 1989;Khan and Hammarstrom, 1990).…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal expression of pregnancy‐specific glycoprotein gene rnCGM1 in rat placenta

Rebstock

Lucas

Weiß

et al. 1993

Developmental Dynamics

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As a basis towards a better understanding of the role of the pregnancy-specific glycoprotein (PSG) family in the maintenance of pregnancy, detailed investigations are described on the expression of a recently identified rat PSG gene (rnCGMl) at the mRNA and protein levels. Using specific oligonucleotide primers, rnCGMl transcripts were identified after reverse transcription, polymerase chain reaction, and hybridization with a radiolabelled, internal oligonucleotide. Transcripts were only found in significant amounts in placenta. In situ hybridization visualized rnCGM1 transcripts at day 14 post coitum (P.c.), in secondary trophoblast giant cells and in the spongiotrophoblast. Only those secondary giant cells lining the maternal decidua were positive. In contrast, primary giant cells did not contain rnCGMl mRNA. At day 18 P.c., rnCGMl transcripts were almost exclusively detectable in the spongiotrophoblast. No rnCGMl transcripts were found in rat embryos of these two developmental stages. Rabbit antisera were generated against the amino-terminal immunoglobulin variable-like domain and against a synthetic peptide containing the last 13 carboxy-terminal amino acids of rnCGMI. Both antisera recognized a 124 kDa protein in day 18 rat placental extracts as identified by Western blot analysis. The anti-peptide antiserum recognized a 116 kDa protein in the serum of a 14 day p.c. pregnant rat that is absent from the sera of non-pregnant females. Taken together, these results confirm exclusive expression of rnCGMl in the rat trophoblast, but unlike human PSG, negligible or no expression is found in other organs, such as fetal liver or salivary glands, indicating a more specialized function of rnCGM1. Its spatiotemporal expression pattern is conducive with a potential role of PSG in protecting the fetus against the maternal immune system andlor in regulating the invasive growth of trophoblast cells. 0 1993 Wiley-Liss, Inc.

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A pregnancy-specific β1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene

Cited by 39 publications

References 26 publications

CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins

CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins

Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.

Spatiotemporal expression of pregnancy‐specific glycoprotein gene rnCGM1 in rat placenta

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