A Pregnant Lady With Aggressive Breast Cancer

Wong, Andrew Barnabas; Lim, Elaine; Robless, Peter; Back, Michael; Wang, Shih‐Chang; Ang, Bee-Kiat; Lim, Siak Piang

doi:10.47102/annals-acadmedsg.v36n6p448

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…[8][9][10] In a previous report of a 51-year-old woman with Poland syndrome and multifocal ductal carcinoma in situ, the patient was successfully treated with a unilateral skin-sparing mastectomy and DIEP flap reconstruction. 11 A prior study reported immediate reconstruction with a pedicled transversus rectus abdominis myocutaneous flap in a 42-year-old patient with Poland syndrome and invasive ductal carcinoma. 12 In the majority of other cases of Poland syndrome with a breast tumor, reported reconstruction after mastectomy was predominantly implant-based and less commonly by use of pedicled flap options.…”

Section: Takeawaysmentioning

confidence: 99%

Bilateral Free Deep Inferior Epigastric Artery Perforator Flaps for Reconstruction following Mastectomy in Poland Syndrome Patients

Malekpour,

Tozzi,

Walker

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: Poland syndrome is classically described as symbrachydactyly, with hypoplasia of the pectoralis major and other upper thoracic musculoskeletal structures. It is thought to be caused by intrauterine interruption in subclavian arterial flow and often includes breast hypoplasia. Affected vasculature can pose a challenge for reconstruction with free flaps because inflow may not be reliable in this patient population. Methods: We present the rare case of a 28-year-old woman with left-sided Poland syndrome, significant family history of breast cancer, and BRCA1+ mutation who underwent bilateral prophylactic nipple-sparing mastectomies with successful immediate bilateral deep inferior epigastric artery perforator free flap reconstruction. The surgical literature in this clinical scenario is also reviewed. Results: Preoperative computed tomography angiography of the chest successfully demonstrated the patency and quantified the caliber of the internal mammary vessels to support free flap breast reconstruction. Conclusions: Free tissue transfer is a viable option for breast reconstruction in patients with Poland syndrome undergoing mastectomy guided by preoperative computed tomography angiography to characterize the internal mammary vasculature.

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Section: Takeawaysmentioning

confidence: 99%

Bilateral Free Deep Inferior Epigastric Artery Perforator Flaps for Reconstruction following Mastectomy in Poland Syndrome Patients

Malekpour,

Tozzi,

Walker

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Treatment of the pregnant mother with cancer: A systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: Solid tumors

Azim

Peccatori

Pavlidis

2010

Cancer Treatment Reviews

118

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The association of cancer and pregnancy is increasingly encountered nowadays in clinical practice. Due to the relative rarity of the situation, it lacks a systematized approach. Different systemic therapies are used in managing cancer with uncertainty regarding the potential hazards they could pose on the pregnancy and/or the fetus. We have performed a systematic review of literature to identify all reports addressing cancer patients who were exposed to any of the known systemic therapies during the course of the pregnancy. The results were discussed in two parts; part I addresses pregnant patients with solid tumors while part I for those with hematological malignancies. In part I, we identified different solid tumors diagnosed and treated during the course of pregnancy. Breast cancer was the most commonly treated followed by ovarian cancer. Other tumors were treated as well including lung cancer, cervical cancer, sarcoma and melanomas. It is important to acknowledge the intent of therapy (palliative vs. curative) and the patients has to be properly counseled to reach an informed decision. We aim to provide a more robust consensus on how to approach these cases and provide a higher degree of evidence to support the safety of applying certain management strategies over the other.

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A Pregnant Lady With Aggressive Breast Cancer

Cited by 2 publications

References 10 publications

Bilateral Free Deep Inferior Epigastric Artery Perforator Flaps for Reconstruction following Mastectomy in Poland Syndrome Patients

Bilateral Free Deep Inferior Epigastric Artery Perforator Flaps for Reconstruction following Mastectomy in Poland Syndrome Patients

Treatment of the pregnant mother with cancer: A systematic review on the use of cytotoxic, endocrine, targeted agents and immunotherapy during pregnancy. Part I: Solid tumors

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