A Preliminary Comparative Study of the Baylis–Hillman Reaction in Ionic Liquid Solution and Gelled Ionic Liquid

Abstract

Baylis–Hillman reaction in ionic liquid ([BMIM][PF6]) solution under stirring conditions and in the presence of a base (DABCO) can also be performed efficiently in non‐stirred gel phase upon gelation of the ionic liquid using a LMW gelator (i.e., (S)‐N‐(1‐oxo‐3‐phenyl‐1‐(tridecylamino)propan‐2‐yl)benzamide). In this preliminary study, the authors have compared both reaction media and the results showed similar behaviors. Interestingly, the ionogel is found to be slightly more effective affording the desired products with moderately higher yields within a reaction period of 24 h.

Catalysis in Supramolecular Systems: the Case of Gel Phases

“…The use of ionogels as reaction media has been also tested to perform the Baylis-Hilmann reaction between 4-fluorobenzaldehyde and methylacrilate (Scheme 14). [25] Scheme 10. Representation of the stereoselective Mannich reaction.…”

Supramolecular Hydrogels with Properties Tunable by Calcium Ions: A Bio-Inspired Chemical System

“…SAFiN hydrogels have a simple and robust preparation process that favors their potential application in different fields, − here as a bioinspired matrix for calcification. They formed through electrostatic and π–π stacking interactions of Boc-L-DOPA­(OBn) 2 -OH molecules in aqueous alkaline conditions.…”

“…The hydrogel formation usually takes place within a few hours through the slow formation of fibers that entrap the solvent. The gels may be constituted of water or an organic solvent, in which a wide variety of materials can be dissolved or suspended and finally trapped into the gel structure, such as graphene, − cells, ,, and catalysts. , After the hydrogel formation, several processes may take place in the confined space of the gel, producing results that are different from that observed in solution.…”