A preliminary evaluation of attenuated total reflection Fourier transform infrared spectroscopy for the hematological analysis of thalassemias

Wan, Jun-Hui; Tian, Pei-Ling; Yin, Hao; Han, Yan; Wei, Xiangcai; Pan, Tao

doi:10.1016/j.clinbiochem.2012.10.001

Cited by 7 publications

(8 citation statements)

References 22 publications

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“…[ 75,76] β-thalassemia patients vs. controls ATR-FTIR spectroscopy -Reduction in α-helix content (1657 cm −1 ), increase in β-sheets (1640 cm −1 and 1680 cm −1 ), alterations in tyrosine ring absorption (1517 cm −1 ), and heightened intensity in bands associated with cysteine SH groups (2550 cm −1 ).…”

Section: Study Population Main Technique Key Spectral Findings Refmentioning

confidence: 99%

“…These findings offer insights for research focusing on the interplay between hematopoietic and mesenchymal stem cells in the bone marrow [74]. In addition, ATR-FTIR spectroscopy has been used in quantitative studies of Hb, MCH, and MCV [75,76]. The optimal wavebands have been determined using the enhanced MW-PLS method, considering stability and consistency across various calibration and prediction sets.…”

Section: Study Population Main Technique Key Spectral Findings Refmentioning

confidence: 99%

See 1 more Smart Citation

Infrared Spectroscopy: A New Frontier in Hematological Disease Diagnosis

Delrue,

Speeckaert,

Oyaert

et al. 2023

IJMS

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Hematological diseases, due to their complex nature and diverse manifestations, pose significant diagnostic challenges in healthcare. The pressing need for early and accurate diagnosis has driven the exploration of novel diagnostic techniques. Infrared (IR) spectroscopy, renowned for its noninvasive, rapid, and cost-effective characteristics, has emerged as a promising adjunct in hematological diagnostics. This review delves into the transformative role of IR spectroscopy and highlights its applications in detecting and diagnosing various blood-related ailments. We discuss groundbreaking research findings and real-world applications while providing a balanced view of the potential and limitations of the technique. By integrating advanced technology with clinical needs, we offer insights into how IR spectroscopy may herald a new era of hematological disease diagnosis.

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Section: Study Population Main Technique Key Spectral Findings Refmentioning

confidence: 99%

Section: Study Population Main Technique Key Spectral Findings Refmentioning

confidence: 99%

Infrared Spectroscopy: A New Frontier in Hematological Disease Diagnosis

Delrue,

Speeckaert,

Oyaert

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…In addition, ATR-FTIR spectroscopy has been applied to the diagnosis of fibromyalgia 17 and thalassemia. 18 Currently, there are no studies applying ATR-FTIR spectroscopy to the differentiation of diabetes, pre-diabetes and healthy people. In order to provide a more economical, rapid and easy-to-promote diagnostic method, herein, for the first time, ATR-FTIR spectroscopy combined with multivariate analysis was used to study human clinical serum samples to establish a diagnostic model and to explore a simple diagnostic method.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, ATR-FTIR spectroscopy has been applied to the diagnosis of fibromyalgia 17 and thalassemia. 18…”

Section: Introductionmentioning

confidence: 99%

Serum-based ATR-FTIR spectroscopy combined with multivariate analysis for the diagnosis of pre-diabetes and diabetes

Pang,

Xing,

Morais

et al. 2024

Analyst

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“…The ATR-FTIR technique has been extensively applied in the areas of life sciences, clinical medicine, and others. [2][3][4][5][6][7][8][9][10][11][12] Partial least-squares (PLS) regression is widely used for comprehensively screening spectroscopic data, extracting information on variables and overcoming the spectral co-linearity. [13][14][15][16][17][18] However, wavelength selection is necessary because the prediction effect of PLS is difficult to improve when the signal-to-noise ratio (SNR) of the wavelength combination is not adequately high.…”

Section: Introductionmentioning

confidence: 99%

Correlation coefficient optimization in partial least-squares regression with application to ATR-FTIR spectroscopic analysis

Chen

Pan

et al. 2015

Anal. Methods

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A wavelength selection method for spectroscopic analysis, named correlation coefficient optimization coupled with partial least-squares (CCO-PLS), is proposed, and was successfully employed for reagent-free ATR-FTIR spectroscopic analysis of albumin (ALB) and globulin (GLB) in human serum. By varying the upper bound of correlation coefficient between absorbance and analyte's content, the CCO-PLS method achieved multiband selection. Two PLS-based methods, which used a waveband having positive peaks of the first loading vector (FLV) and a combination of positive peaks of the correlation coefficient spectrum, were also conducted for comparison. Based on the leave-one-out cross-validation for CCO-PLS, appropriate waveband combinations for ALB and GLB were selected, the root-mean-square errors of prediction for validation samples were 1.36 and 1.35 (g L À1 ) for ALB and GLB, respectively, which were better than the two comparison methods. The CCO-PLS method provided a new approach for multi-band selection to achieve high analytical accuracy for molecular absorption bands that were composed of several spaced wavebands.

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A preliminary evaluation of attenuated total reflection Fourier transform infrared spectroscopy for the hematological analysis of thalassemias

Cited by 7 publications

References 22 publications

Infrared Spectroscopy: A New Frontier in Hematological Disease Diagnosis

Infrared Spectroscopy: A New Frontier in Hematological Disease Diagnosis

Serum-based ATR-FTIR spectroscopy combined with multivariate analysis for the diagnosis of pre-diabetes and diabetes

Correlation coefficient optimization in partial least-squares regression with application to ATR-FTIR spectroscopic analysis

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