A Preliminary Investigation of Corpus Callosum and Anterior Commissure Aberrations in Aggressive Youth with Bipolar Disorders

Saxena, Kirti; Tamm, Leanne; Walley, Annie; Simmons, Alex; Rollins, Nancy; Chia, Jonathan M.; Soares, Jair C.; Emslie, Graham J.; Fan, Xin; Huang, Hao

doi:10.1089/cap.2011.0063

Cited by 63 publications

(41 citation statements)

References 46 publications

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“…A similar whole‐brain DTI study comparing the FA among 19 psychotic BD I patients, 21 unaffected FDR, and 18 HC found significant reductions in FA in the BD I patients as compared to controls, but with no significant difference between the unaffected FDR of patients and controls . Similar findings have been observed in many other DTI studies in subjects with BD or at high genetic risk of BD . One study presented a contrasting finding of increased FA in the genu of the corpus callosum .…”

Section: Discussionsupporting

confidence: 71%

Diffusion tensor imaging tractography study in bipolar disorder patients compared to first‐degree relatives and healthy controls

Mahapatra

Khandelwal

Sharan

et al. 2017

Psychiatry Clin Neurosci

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Section: Discussionsupporting

confidence: 71%

Diffusion tensor imaging tractography study in bipolar disorder patients compared to first‐degree relatives and healthy controls

Mahapatra

Khandelwal

Sharan

et al. 2017

Psychiatry Clin Neurosci

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“…After randomise processing in TBSS, the cluster filtering procedures described above were conducted with a home-made IDL program (ITT, Boulder, CO). Furthermore, small-volume false discovery rate (FDR) correction (Versace, Almeida et al 2008; Cullen, Klimes-Dougan et al 2010; Saxena, Tamm et al 2012) was employed with R software package (R-2.13.1). Specifically, the small volumes were anatomically defined regional masks with the disrupted clusters detected above as the centers and containing skeleton voxels 100 times larger than the disrupted clusters.…”

Section: Methodsmentioning

confidence: 99%

White matter integrity in physically fit older adults

et al. 2013

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Background White matter (WM) integrity declines with normal aging. Physical activity may attenuate age-related WM integrity changes and improve cognitive function. This study examined brain WM integrity in Masters athletes who have engaged in life-long aerobic exercise training. We tested the hypothesis that life-long aerobic training is associated with improved brain WM integrity in older adults. Methods Ten Masters athletes (3 females, age=72.2±5.3yrs, endurance training>15yrs) and 10 sedentary older adults similar in age and educational level (2 females, age=74.5±4.3yrs) participated. MRI fluid-attenuated-inversion-recovery (FLAIR) images were acquired to assess white matter hyper intensities (WMH) volume. Diffusion tensor imaging (DTI) was performed to evaluate the WM microstructural integrity with a DTI-derived metric, fractional anisotropy (FA) and mean diffusivity (MD). Results After normalization to whole-brain volume, Masters athletes showed an 83% reduction in deep WMH volume relative to their sedentary counterparts (0.05 ± 0.05% vs. 0.29 ± 0.29%, p<0.05). In addition, we found an inverse relationship between aerobic fitness (VO2max) and deep WMH volume (r=−0.78, p<0.001). Using TBSS, Masters athletes showed higher FA values in the right superior corona radiata (SCR), both sides of superior longitudinal fasciculus (SLF), right inferior fronto-occipital fasciculus (IFO), and left inferior longitudinal fasciculus (ILF). In addition, Masters athletes also showed lower MD values in the left posterior thalamic radiation (PTR) and left cingulum hippocampus. Conclusions These findings suggest that life-long exercise is associated with reduced WMH and may preserve WM fiber microstructural integrity related to motor control and coordination in older adults.

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“…Executive function and processing speed were correlated with anisotropy of the anterior thalamic radiation and uncinate fasciculus in late life depression (Sexton et al, 2011). Abnormal myelination and morphometry of callosum interhemispheric connections have been consistently associated with BD (Bearden et al, 2011) and dimensions of BD psychopatology, such as aggression (Saxena et al, 2012) and suicide (Matsuo et al, 2010).…”

Section: Lithium and Gsk3-b Effects On White Matter F Benedetti Et Almentioning

confidence: 96%

Lithium and GSK3-β Promoter Gene Variants Influence White Matter Microstructure in Bipolar Disorder

Benedetti

Bollettini

Barberi

et al. 2012

Neuropsychopharmacol

147

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Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase 3-b (GSK3-b). The less active GSK3-b promoter gene variants have been associated with less detrimental clinical features of BD. GSK3-b gene variants and lithium can influence brain gray matter structure in psychiatric conditions. Diffusion tensor imaging (DTI) measures of white matter (WM) integrity showed widespred disruption of WM structure in BD. In a sample of 70 patients affected by a major depressive episode in course of BD, we investigated the effect of ongoing long-term lithium treatment and GSK3-b promoter rs334558 polymorphism on WM microstructure, using DTI and tract-based spatial statistics with threshold-free cluster enhancement. We report that the less active GSK3-b rs334558*C gene-promoter variants, and the long-term administration of the GSK3-b inhibitor lithium, were associated with increases of DTI measures of axial diffusivity (AD) in several WM fiber tracts, including corpus callosum, forceps major, anterior and posterior cingulum bundle (bilaterally including its hippocampal part), left superior and inferior longitudinal fasciculus, left inferior fronto-occipital fasciculus, left posterior thalamic radiation, bilateral superior and posterior corona radiata, and bilateral corticospinal tract. AD reflects the integrity of axons and myelin sheaths. We suggest that GSK3-b inhibition and lithium could counteract the detrimental influences of BD on WM structure, with specific benefits resulting from effects on specific WM tracts contributing to the functional integrity of the brain and involving interhemispheric, limbic, and large frontal, parietal, and fronto-occipital connections.

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A Preliminary Investigation of Corpus Callosum and Anterior Commissure Aberrations in Aggressive Youth with Bipolar Disorders

Cited by 63 publications

References 46 publications

Diffusion tensor imaging tractography study in bipolar disorder patients compared to first‐degree relatives and healthy controls

Diffusion tensor imaging tractography study in bipolar disorder patients compared to first‐degree relatives and healthy controls

White matter integrity in physically fit older adults

Lithium and GSK3-β Promoter Gene Variants Influence White Matter Microstructure in Bipolar Disorder

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