A Preliminary Investigation on Plasma Cell Adhesion Molecules Levels by Protein Microarray Technology in Major Depressive Disorder

Liu, Wanying; Zheng, Yingxia; Zhang, Fuxu; Zhu, Mo; Guo, Qian; Xu, Hua; Liu, Caiping; Chen, Haiying; Wang, Xiaoliang; Hu, Yao; Zhang, Tianhong; Lin, Zhiguang; Zhang, Chen; Li, Guanjun; Jiang, Kaida; Liu, Xiaohua

doi:10.3389/fpsyt.2021.627469

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…In addition, loss of cln3 ( Huber et al, 2017 ) or cln5 ( Huber and Mathavarajah, 2018b ) in D. discoideum causes adhesion defects. Increased NRCAM levels have been reported in the blood plasma of patients diagnosed major depressive disorder ( Liu et al, 2021 ), and the function of NRCAM has been associated with Alzheimer's disease ( Hu et al, 2010 ). However, recent work suggests that NRCAM is not a suitable CSF biomarker for differentiating between different forms of dementia ( Müller et al, 2015 ); therefore, its use as an NCL biomarker requires further evaluation.…”

Section: Potential Biomarkers Identified In Animal Models and Humansmentioning

confidence: 99%

Altered protein secretion in Batten disease

Huber

2021

Disease Models &Amp; Mechanisms

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The neuronal ceroid lipofuscinoses (NCLs), collectively known as Batten disease, are a group of neurological diseases that affect all ages and ethnicities worldwide. There are 13 different subtypes of NCL, each caused by a mutation in a distinct gene. The NCLs are characterized by the accumulation of undigestible lipids and proteins in various cell types. This leads to progressive neurodegeneration and clinical symptoms including vision loss, progressive motor and cognitive decline, seizures, and premature death. These diseases have commonly been characterized by lysosomal defects leading to the accumulation of undigestible material but further research on the NCLs suggests that altered protein secretion may also play an important role. This has been strengthened by recent work in biomedical model organisms, including Dictyostelium discoideum, mice, and sheep. Research in D. discoideum has reported the extracellular localization of some NCL-related proteins and the effects of NCL-related gene loss on protein secretion during unicellular growth and multicellular development. Aberrant protein secretion has also been observed in mammalian models of NCL, which has allowed examination of patient-derived cerebrospinal fluid and urine for potential diagnostic and prognostic biomarkers. Accumulated evidence links seven of the 13 known NCL-related genes to protein secretion, suggesting that altered secretion is a common hallmark of multiple NCL subtypes. This Review highlights the impact of altered protein secretion in the NCLs, identifies potential biomarkers of interest and suggests that future work in this area can provide new therapeutic insight.

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Section: Potential Biomarkers Identified In Animal Models and Humansmentioning

confidence: 99%

Altered protein secretion in Batten disease

Huber

2021

Disease Models &Amp; Mechanisms

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“…However, only a few studies on a topic are present. Only recently, Liu et al [ 40 ] documented increased levels of Carcinoembryonic Antigen Related Cell Adhesion Molecule-1 (CEACAM-1) and Neural Cell Adhesion Molecule (NCAM) in plasma of patients with major depressive disorder (MDD). Learning and memory –involve a vast array of CAMs [ 12 , 22 , 29 ]; therefore, we will present only selected examples here.…”

Section: Cams In a Health And A Diseasementioning

confidence: 99%

Physicochemical Principles of Adhesion Mechanisms in the Brain

Stachowicz

2023

IJMS

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The brain functions through neuronal circuits and networks that are synaptically connected. This type of connection can exist due to physical forces that interact to stabilize local contacts in the brain. Adhesion is a fundamental physical phenomenon that allows different layers, phases, and tissues to connect. Similarly, synaptic connections are stabilized by specialized adhesion proteins. This review discusses the basic physical and chemical properties of adhesion. Cell adhesion molecules (CAMs) such as cadherins, integrins, selectins, and immunoglobulin family of cell adhesion molecules (IgSF) will be discussed, and their role in physiological and pathological brain function. Finally, the role of CAMs at the synapse will be described. In addition, methods for studying adhesion in the brain will be presented.

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Correlating plasma protein profiles with symptomatology and treatment response in acute phase and early remission of major depressive disorder

Křenek,

Bartečková,

Makarová

et al. 2024

Front. Psychiatry

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ObjectivesThis study aimed to explore the relationship between plasma proteome and the clinical features of Major Depressive Disorder (MDD) during treatment of acute episode.MethodsIn this longitudinal observational study, 26 patients hospitalized for moderate to severe MDD were analyzed. The study utilized Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS) alongside clinical metrics, including symptomatology derived from the Montgomery-Åsberg Depression Rating Scale (MADRS). Plasma protein analysis was conducted at the onset of acute depression and 6 weeks into treatment. Analytical methods comprised of Linear Models for Microarray Data (LIMMA), Weighted Correlation Network Analysis (WGCNA), Generalized Linear Models, Random Forests, and The Database for Annotation, Visualization and Integrated Discovery (DAVID).ResultsFive distinct plasma protein modules were identified, correlating with specific biological processes, and uniquely associated with symptom presentation, the disorder’s trajectory, and treatment response. A module rich in proteins related to adaptive immunity was correlated with the manifestation of somatic syndrome, treatment response, and inversely associated with achieving remission. A module associated with cell adhesion was linked to affective symptoms and avolition, and played a role in the initial episodes and treatment response. Another module, characterized by proteins involved in blood coagulation and lipid transport, exhibited negative correlations with a variety of MDD symptoms and was predominantly associated with the manifestation of psychotic symptoms.ConclusionThis research points to a complex interplay between the plasma proteome and MDD’s clinical presentation, suggesting that somatic, affective, and psychotic symptoms may represent distinct endophenotypic manifestations of MDD. These insights hold potential for advancing targeted therapeutic strategies and diagnostic tools.LimitationsThe study’s limited sample size and its naturalistic design, encompassing diverse treatment modalities, present methodological constraints. Furthermore, the analysis focused on peripheral blood proteins, with potential implications for interpretability.

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A Preliminary Investigation on Plasma Cell Adhesion Molecules Levels by Protein Microarray Technology in Major Depressive Disorder

Cited by 3 publications

References 37 publications

Altered protein secretion in Batten disease

Altered protein secretion in Batten disease

Physicochemical Principles of Adhesion Mechanisms in the Brain

Correlating plasma protein profiles with symptomatology and treatment response in acute phase and early remission of major depressive disorder

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