A preliminary profile of neuropsychological deficits associated with major depression

Veiel, Hans O. F.

doi:10.1080/01688639708403745

Cited by 444 publications

(315 citation statements)

References 52 publications

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“…In addition, the findings of the lesion study by Shammi and Stuss (1999) suggested a contribution of the PFC to humor processing. The observed humor processing deficits in the present investigation may thus be linked to PFC dysfunction in major depression, as shown by recent studies (Veiel, 1997).…”

Section: Discussionsupporting

confidence: 85%

“…Major depression is associated with cognitive deficits including memory and executive impairment (Veiel, 1997;Zakzanis et al, 1998). These in turn have been linked to dysfunction of fronto-subcortical networks including the dorsolateral prefrontal cortex (DLPFC), the ventrolateral prefrontal cortex (VLPFC), the anterior cingulate cortex (ACC), the basal ganglia and the hippocampus (Brody et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Executive function, mentalizing and humor in major depression

Uekermann

Channon

Lehmkämper

et al. 2007

J Int Neuropsychol Soc

124

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Major depression is associated with cognitive deficits including memory, executive functions, and affect perception, which have been linked to dysfunction of fronto-subcortical networks. However, little is known about social cognition on more complex socially relevant tasks, such as humor processing. In this investigation a computerized humor-processing task was administered to 27 patients with a diagnosis of major depression (Dep) and 27 healthy controls (HC). Theory of mind (mentalizing) and executive functions were also assessed. Both groups were similar in IQ, age, and gender. Depressed patients performed below the control group with respect to both affective and cognitive aspects of humor processing, and these were related to mentalizing and executive performance. Our findings suggest social cognition deficits in major depression. Ability to process humor and appreciate mentalistic perspectives may in turn influence social interactions and should be given consideration in therapeutic approaches to depression. (JINS, 2008, 14, 55-62.)

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Executive function, mentalizing and humor in major depression

Uekermann

Channon

Lehmkämper

et al. 2007

J Int Neuropsychol Soc

124

View full text Add to dashboard Cite

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“…The DAN network shows increased synchronization during goal-directed processes (Corbetta et al, 1998;Kim, 2010), and MDD is characterized by poor performance in cognitive control tasks (Veiel, 1997;Zakzanis et al, 1998) as well as dysfunction in dorsolateral and ventrolateral prefrontal cortex and anterior cingulate cortex during cognitive control tasks (Brody et al, 2001;Rogers et al, 2004). MDD is also characterized by altered orbital frontal cortex activation in the context of processing rewards Smoski et al, 2009), anticipating rewards , and while processing sad distracting information (Elliott et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Crowther

Smoski

Minkel

et al. 2015

Neuropsychopharmacol

119

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Despite the heterogeneous symptom presentation and complex etiology of major depressive disorder (MDD), functional neuroimaging studies have shown with remarkable consistency that dysfunction in mesocorticolimbic brain systems are central to the disorder. Relatively less research has focused on the identification of biological markers of response to antidepressant treatment that would serve to improve the personalized delivery of empirically supported antidepressant interventions. In the present study, we investigated whether resting-state functional brain connectivity (rs-fcMRI) predicted response to Behavioral Activation Treatment for Depression, an empirically validated psychotherapy modality designed to increase engagement with rewarding stimuli and reduce avoidance behaviors. Twenty-three unmedicated outpatients with MDD and 20 matched nondepressed controls completed rs-fcMRI scans after which the MDD group received an average of 12 sessions of psychotherapy. The mean change in Beck Depression Inventory-II scores after psychotherapy was 12.04 points, a clinically meaningful response. Resting-state neuroimaging data were analyzed with a seed-based approach to investigate functional connectivity with four canonical resting-state networks: the default mode network, the dorsal attention network, the executive control network, and the salience network. At baseline, the MDD group was characterized by relative hyperconnectivity of multiple regions with precuneus, anterior insula, dorsal anterior cingulate cortex (dACC), and left dorsolateral prefrontal cortex seeds and by relative hypoconnectivity with intraparietal sulcus, anterior insula, and dACC seeds. Additionally, connectivity of the precuneus with the left middle temporal gyrus and connectivity of the dACC with the parahippocampal gyrus predicted the magnitude of pretreatment MDD symptoms. Hierarchical linear modeling revealed that response to psychotherapy in the MDD group was predicted by pretreatment connectivity of the right insula with the right middle temporal gyrus and the left intraparietal sulcus with the orbital frontal cortex. These results add to the nascent body of literature investigating pretreatment rs-fcMRI predictors of antidepressant treatment response and is the first study to examine rs-fcMRI predictors of response to psychotherapy.

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“…In a meta-analysis, Veiel (1997) found the largest differences between depressed patients and healthy controls on set shifting and inhibition tasks. In addition, planning and working memory impairments have been frequently observed in major depression (see DeBattista, 2005).…”

Section: Introductionmentioning

confidence: 99%

Perception of affective prosody in major depression: A link to executive functions?

Uekermann

Abdel‐Hamid

Lehmkämper

et al. 2008

J Int Neuropsychol Soc

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Major depression is associated with impairments of executive functions and affect perception deficits, both being linked to dysfunction of fronto-subcortical networks. So far, little is known about the relationship between cognitive and affective deficits in major depression. In the present investigation, affect perception and executive functions were assessed in 29 patients with a diagnosis of major depression (Dep) and 29 healthy controls (HC). Both groups were comparable on IQ, age, and gender distribution. Depressed patients showed deficits of perception of affective prosody, which were significantly related to inhibition, set shifting, and working memory. Our findings suggest a significant association between cognitive deficits and affect perception impairments in major depression, which may be of considerable clinical relevance and might be addressed in treatment approaches. Future studies are desirable to investigate the nature of the association in more detail. (JINS, 2008, 14, 552-561.)

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A preliminary profile of neuropsychological deficits associated with major depression

Cited by 444 publications

References 52 publications

Executive function, mentalizing and humor in major depression

Executive function, mentalizing and humor in major depression

Resting-State Connectivity Predictors of Response to Psychotherapy in Major Depressive Disorder

Perception of affective prosody in major depression: A link to executive functions?

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