A Preliminary Report on Cigarette Smoking and the Incidence of Prematurity

Simpson, W.

doi:10.1007/978-94-011-6621-8_39

Cited by 88 publications

(112 citation statements)

References 0 publications

Supporting

Mentioning

104

Contrasting

Unclassified

Order By: Relevance

“…Smoking has been associated with preterm births for more than half a century (Simpson, 1957). Smoking cessation by women of childbearing age, ideally prior to pregnancy or early in pregnancy, may have more potential for reducing preterm and LBW birth than any other single strategy.…”

Section: Cigarette Smokingmentioning

confidence: 99%

Preterm Labor and Birth: What Have We Learned in the Past Two Decades?

Moore

2003

Journal of Obstetric, Gynecologic & Neonatal Nursing

View full text Add to dashboard Cite

Section: Cigarette Smokingmentioning

confidence: 99%

Preterm Labor and Birth: What Have We Learned in the Past Two Decades?

Moore

2003

Journal of Obstetric, Gynecologic & Neonatal Nursing

View full text Add to dashboard Cite

“…Maternal tobacco smoking during pregnancy is a major societal health concern for developing offspring. Gestational tobacco smoke exposure produces restricted intrauterine growth (Kramer, 1987;Kramer et al, 1990) and low birth weight (Meyer and Comstock, 1972;Simpson, 1957;Wang et al, 2002;Ward et al, 2007), and is associated with sudden infant death syndrome (Fleming and Abbreviations: ASR, acoustic startle response; CN, cochlear nuclei; GD, gestational day; IC, inferior colliculus; ISI, interstimulus interval; IV, intravenous; nAChRs, nicotinic acetylcholine receptor; PnC, caudal pontine reticular nucleus; PND, postnatal day; PPI, prepulse inhibition; PPTg, pedunculopontine tegmental nucleus; SC, superior colliculus; SUD, substance use disorder. Blair, 2007).…”

Section: Introductionmentioning

confidence: 99%

Prenatal IV nicotine exposure produces a sex difference in sensorimotor gating of the auditory startle reflex in adult rats

Lacy

Mactutus

Harrod

2010

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Maternal smoking during pregnancy is associated with auditory processing deficits in children; these effects have been confirmed with animal models of continuous high-dose prenatal nicotine exposure. The present experiments utilized a novel, low-dose, intermittent, intravenous (IV) gestational nicotine exposure model to investigate potential deficits on the preattentive process of sensorimotor gating, as indexed by prepulse inhibition (PPI), in preweanling and adult rat offspring. Pregnant dams received bolus IV injections of nicotine (0.05 mg/kg/injection) 3x/day on gestational days 8–21. Auditory and tactile stimulus modalities were probed with tone and air puff prepulse stimuli, respectively. These prepulse stimuli preceded a 100 dB(A) startle tone by six different interstimulus intervals (ISIs; 0, 8, 40, 80, 120, 4000 ms) to define a curve of response inhibition. The magnitude of PPI increased with age, from 59 to 81% inhibition. Preweanlings (PND 14 and 18) and adults (PND 75) gestationally exposed to nicotine exhibited altered startle responding relative to controls, but the nature of the deficit became more localized at later ages. The entire curve of response inhibition in preweanlings exposed to prenatal nicotine (PND 14) was shifted up relative to controls, and notably, did not interact with prepulse stimulus modality, suggesting a generalized increased sensorimotor responsiveness as a function of prenatal nicotine. At PND 18, a shift in the response curve across all ISIs was again noted, but varied as a function of prepulse stimulus modality; the increased sensorimotor responsiveness was specific to the auditory, but not tactile, sensory modality. In adulthood, male and females animals prenatally exposed to nicotine were differentially sensitive to modulation by the ISIs, relative to control male and female animals. Specifically, despite robust PPI, adult females exposed to gestational nicotine were relatively insensitive to changes in ISI from 8–120 ms; in contrast, the robust PPI of nicotine-exposed males demonstrated a clear focal point of inhibition at 40 ms. These findings indicate that a low, daily dosing of IV prenatal nicotine produces long-lasting alterations in auditory PPI. An important implication of this research is that “chipping” with smoked-tobacco products during pregnancy may produce enduring changes in sensorimotor processing.

show abstract

“…The adverse effects of maternal smoking on pregnancy outcome were first reported in 1957, 1 and since then it has been implicated as a cause of impaired fetal growth, preterm birth, and raised perinatal and infant mortality rates. 2±9 During Paediatric and Perinatal Epidemiology 1999, 13, 245±253 this time there has been an overall decline in the prevalence of smoking in the British population, although rates are still well above the Health of the Nation target of 20% by the year 2000.…”

Section: Introductionmentioning

confidence: 99%

Maternal cigarette smoking and pregnancy outcome

Tuthill

Stewart

Coles

et al. 1999

Paediatric Perinatal Epid

View full text Add to dashboard Cite

Maternal smoking rates in pregnancy have declined, particularly in the non-manual social classes, and perinatal mortality rates have fallen over the last 20 years. We have therefore re-evaluated the relationship between maternal cigarette smoking and pregnancy outcome against this background. A total of 608 stillbirths and 634 infant deaths were identified using the All Wales Perinatal Survey. The cause of death was classified using the clinicopathological system. Maternal smoking rates and social class groupings were compared with those in a cohort of 16047 survivors born to women resident in South Glamorgan. The smoking rate was 37.8% in mothers of babies who died compared with 27.2% in mothers of survivors, an odds ratio (OR) of 1.63 [95% CI 1.44, 1.84]. The OR for unexplained stillbirth was 1.72 [95% CI 1.38, 2.13], placental abruption 2.07 [95% CI 1.29, 3.31], infection 3.70 [95% CI 2.23, 6.13] and sudden infant death syndrome 4.84 [95% CI 3.05, 7.69]. Maternal smoking was not associated with death due to prematurity or a congenital anomaly. Despite changes in smoking habits and the causes of perinatal death, smoking during pregnancy continues to be strongly associated with fetal and infant mortality. It is important that health promotion activities are effective in reducing smoking during pregnancy.

show abstract

A Preliminary Report on Cigarette Smoking and the Incidence of Prematurity

Cited by 88 publications

References 0 publications

Preterm Labor and Birth: What Have We Learned in the Past Two Decades?

Preterm Labor and Birth: What Have We Learned in the Past Two Decades?

Prenatal IV nicotine exposure produces a sex difference in sensorimotor gating of the auditory startle reflex in adult rats

Maternal cigarette smoking and pregnancy outcome

Contact Info

Product

Resources

About