The present study was based on both bibliographic sources and the survey to the documentation of invasive plants in Kalahandi district, Odisha, India. A total of 108 species belonging to 91 genera and 37 families are reported. The highest number of species i.e. 15 no. were contributed from both the family Asteraceae and Fabaceae; followed by nine species from Poaceae; six species (Amaranthaceae); five species each from the family Convolvulaceae and Malvaceae; four species each from four families (Apocyanaceae, Euphorbiaceae, Polygonaceae and Solanaceae); three species each from two family (Acanthaceae and Lamiaceae); two species each from six family (Boraginaceae, Cyperaceae, Passifloraceae, Pontederiaceae, Salviniaceae and Verbenaceae); rest 18 families contributed one species each. The diversity of exotic plants was highest in the wasteland (52 spp.), followed by 35 species contributed from the cultivated field, roadside (30 spp.), 15 spp. each from both forest and homestead, river bed (12 spp.), and aquatic (5 spp.). Among these the maximum species contribution is from Tropical America (36 spp.), followed by North America (20 spp.), Africa (19 spp.), Asia (16 spp.), South America (14 spp.), Australia (5 spp.), Europe (4 spp.), Central America (3 spp.), both the sub-trophical America and Mediterranean contributed one species each. The uses of exotic plants for various purposes indicated by the native peoples are discussed here. The present study gives complete and efficient documentation of invasive plants in Kalahandi district of Odisha that will provide a tool for maintenance of the local biodiversity.