The number of pet lovers is increasing, especially during the Covid 19 pandemic. Unfortunately, this has not been balanced with awareness of the potential for animal diseases that can be transmitted to humans or vice versa, called zoonotic diseases. The risk of zoonotic diseases can be reduced with proper knowledge by pet owners. This study aims to analyze the factors that influence zoonosis awareness among cat owners in Depok City. Data collection was carried out through online and offline surveys. The number of respondents was 215 people using voluntary sampling. Data were processed using binary logistic regression. The research results showed that most respondents did not know about zoonotic diseases (75%) and did not know the dangers (79%) even though their cats had been treated at an animal health center. Only 46% of respondents stated that their animals were vaccinated and provided special cages (65%). Factors influencing awareness of zoonosis are educational factors, community involvement, vaccination, and the number of animals kept. Meanwhile, the variables gender, age, provision of special cages, and expenses for animals do not influence zoonosis awareness. Vaccination campaigns are considered quite effective in promoting the dangers of zoonosis. The pet owners who recognize zoonosis tend to limit the number of pets.