2012
DOI: 10.1016/j.gene.2011.11.007
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A preliminary sketch of horn cancer transcriptome in Indian zebu cattle

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Cited by 11 publications
(10 citation statements)
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“…Gene expression profiling has not been studied in depth in HC yet due to, regional economy and limitations of available technologies. A preliminary sketch was drawn on low coverage‐data for transcriptome profiling in Bos indicus . Similar to that of many other cancers, unduly expressed or under expressed genes deregulate biochemical pathways including metabolic and signalling pathways resulting in carcinogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…Gene expression profiling has not been studied in depth in HC yet due to, regional economy and limitations of available technologies. A preliminary sketch was drawn on low coverage‐data for transcriptome profiling in Bos indicus . Similar to that of many other cancers, unduly expressed or under expressed genes deregulate biochemical pathways including metabolic and signalling pathways resulting in carcinogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…In the previous study [3], the total raw reads generated after processing of sequencing data were 392,692 and 516,696 for horn normal (HN) and cancer (HC) tissue, respectively. With minimum overlap of 20 bases and minimum identity of 90%, the GS de novo assembler (Roche Diagnostics, USA) could assemble 102,147 and 137,314 reads to generate 4,095 and 5,805 contigs for HN and HC, respectively.…”
Section: Analysis Of Splice Variantsmentioning
confidence: 99%
“…It leads to a heavy economic loss due to reduction in draught power, chronic morbidity and mortality of animals. Recently, we reported the preliminary transcriptome analysis of horn cancer in Indian zebu cattle (Kankrej breed), identifying differential expression of potential cancer associated transcripts [3].…”
Section: Introductionmentioning
confidence: 99%
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“…The main difficulties in early diagnosis include the absence of specific markers and the lack of a complete understanding of the cellular hierarchy of morphogenesis of the horn core epithelium. At molecular level, HC has been studied previously for novel gene content (Jakhesara et al 2013b) and global gene expression (Tripathi et al 2012). …”
Section: Introductionmentioning
confidence: 99%