A preliminary study of association between adolescent estradiol level and dorsolateral prefrontal cortex activity during emotion regulation

Chung, Yu Sun; Poppe, Andrew; Novotny, Stephanie; Epperson, C. Neill; Kober, Hedy; Blumberg, Hilary P.; Ochsner, Kevin N.; Gross, James J.; Pearlson, Godfrey D.; Stevens, Michael C.

doi:10.1016/j.psyneuen.2019.104398

Cited by 23 publications

(12 citation statements)

References 49 publications

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“…Estrogen is also known to selectively increase blood flow in executive areas in adults (79) and emerging evidence has established a link between higher estradiol levels and greater dorsolateral prefrontal cortex activity during emotion regulation in adolescents (80). It is possible that hormone-mediated mechanisms contribute to observed sex differences in coupling within the FPN.…”

Section: Discussionmentioning

confidence: 99%

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

Baller

Valcarcel

Adebimpe

et al. 2021

Preprint

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To support brain development during youth, the brain must balance energy delivery and consumption. Previous studies in adults have demonstrated high coupling between cerebral blood flow and brain function as measured using functional neuroimaging, but how this relationship evolves over adolescence is unknown. To address this gap, we studied a sample of 831 children and adolescents (478 females, ages 8-22) from the Philadelphia Neurodevelopmental Cohort who were scanned at 3T with both arterial spin labeled (ASL) MRI and resting-state functional MRI (fMRI). Local coupling between cerebral blood flow (CBF, from ASL) and the amplitude of low frequency fluctuations (ALFF, from fMRI) was first quantified using locally weighted regressions on the cortical surface. We then used generalized additive models to evaluate how CBF-ALFF coupling was associated with age, sex, and executive function. Enrichment of effects within canonical functional networks was evaluated using spin-based permutation tests. Our analyses revealed tight CBF-ALFF coupling across the brain. Whole-brain CBF-ALFF coupling decreased with age, largely driven by coupling decreases in the inferior frontal cortex, precuneus, visual cortex, and temporoparietal cortex (pfdr <0.05). Females had stronger coupling in the frontoparietal network than males (pfdr <0.05). Better executive function was associated with decreased coupling in the somatomotor network (pfdr <0.05). Overall, we found that CBF-ALFF coupling evolves in development, differs by sex, and is associated with individual differences in executive function. Future studies will investigate relationships between maturational changes in CBF-ALFF coupling and the presence of psychiatric symptoms in youth.

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Section: Discussionmentioning

confidence: 99%

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

Baller

Valcarcel

Adebimpe

et al. 2021

Preprint

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“…In normative development, puberty is associated with dramatic changes in the brain, neuroendocrine system, and HPA axis (125,126). Puberty alters the function of each of these systems and their interactionsfor example, circulating sex hormones and inflammatory markers predict brain function related to emotion regulation and executive control in adolescence (127,128). Accumulating cross-species work suggests that ELA not only modulates brain and biology concurrently, but also may have ongoing or novel effects during and after puberty.…”

Section: Pubertal Stress Recalibration Hypothesismentioning

confidence: 99%

Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence

Leal

Silvers

2021

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Early life adversity (ELA) exposure (including trauma, abuse, neglect or institutional care) is a precursor to poor physical and mental health outcomes, and is implicated in 30% of adult mental illness. In recent decades, ELA research has increasingly focused on characterizing factors that confer resilience to ELA, and on identifying opportunities for intervention. In this review, we describe recent behavioral and neurobiological resilience work that suggests adolescence (a period marked by heightened plasticity, development of key neurobiological circuitry, and sensitivity to the social environment) may be a particularly opportune moment for ELA intervention. We review intrapersonal factors associated with resilience that become increasingly important during adolescence (specifically, reward processing, affective learning, and self-regulation), and describe the contextual factors (family, peers, and broader social environment) that modulate them. Additionally, we describe how the onset of puberty interacts with each of these factors, and explore recent findings that point to possible "pubertal recalibration" of ELA exposure as an opportunity for intervention. Lastly, we conclude by describing considerations and future directions for resilience research in adolescents, with a focus on understanding developmental trajectories using dimensional, holistic models of resilience.

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“…There is evidence that E2 receptors are located in the frontal cortex ( 13 ). Previous studies have reported that E2 level had an association with activity of the frontal cortex during emotion regulation and sexual stimuli ( 12 , 43 ). In line with previous findings, the positive correlation between E2 level and brain activity in the right SFG suggested that E2 might positively contribute to the function of the frontal cortical system in related tasks.…”

Section: Discussionmentioning

confidence: 93%

Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level

Guo

Qiu

et al. 2021

Front. Endocrinol.

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ObjectiveSerum hormone deficiencies during menopause transition may affect spontaneous brain activity and global cognition. The purpose of this study was to explore the differences in spontaneous brain activity between premenopausal and perimenopausal women, and to investigate the associations between spontaneous brain activity, serum hormone levels and global cognition.MethodsThirty-two premenopausal women (47.75 ± 1.55 years) and twenty-five perimenopausal women (51.60 ± 1.63 years) underwent resting-state functional MRI (fMRI) scan. Clinical information including Mini-Mental State Examination (MMSE), levels of estradiol (E2), free testosterone, progesterone, prolactin, follicle-stimulating hormone and luteinizing hormone were measured. Regional homogeneity (ReHo) was used to evaluate spontaneous brain activity alterations between perimenopausal and premenopausal women. Correlation analysis was used to investigate the associations between brain functional alterations and clinical measures in perimenopausal group.ResultsThe results demonstrated increased ReHo value in the right lingual gyrus (LG) and decreased ReHo value in the right superior frontal gyrus (SFG) in perimenopausal women compared with premenopausal women. In perimenopausal group, ReHo of the right LG showed a negative correlation with level of E2 (r = -0.586, p = 0.002), ReHo of the right SFG showed a positive correlation with level of E2 (r = 0.470, p = 0.018) and MMSE (r = 0.614, p = 0.001).ConclusionsThe results demonstrated that women approaching menopause suffered from altered functions in brain regions related to cognitive function, working memory, the results also revealed a direct association between levels of E2 and brain functions in perimenopausal women.

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A preliminary study of association between adolescent estradiol level and dorsolateral prefrontal cortex activity during emotion regulation

Cited by 23 publications

References 49 publications

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

Developmental coupling of cerebral blood flow and fMRI fluctuations in youth

Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence

Altered Spontaneous Brain Activity in Women During Menopause Transition and Its Association With Cognitive Function and Serum Estradiol Level

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