2019
DOI: 10.1101/624288
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A preliminary study of resting brain metabolism in treatment-resistant depression before and after treatment with olanzapine-fluoxetine combination

Abstract: 19Treatment-resistant depression (TRD) occurs in many patients and causes high 20 morbidity and mortality. Because TRD subjects are particularly difficult to study 21 especially longitudinally, biological data remain very limited. In a preliminary study to 22 judge feasibility and power, 25 TRD patients were referred from specialty psychiatric 23 practices. All were severely and chronically depressed and mostly had comorbid 24 psychiatric disorders as is typical in TRD. Nine patients were able to complete all … Show more

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