2005
DOI: 10.1089/vbz.2005.5.127
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A Preliminary Study of the Patterns of Sin Nombre Viral Infection and Shedding in Naturally Infected Deer Mice (Peromyscus maniculatus)

Abstract: Deer mice (Peromyscus maniculatus) were trapped in southern Manitoba, Canada and tested for evidence of Sin Nombre virus infection. Viral genome was amplified from tissues as well as saliva/ oropharyngeal fluid, and urine samples were collected from seropositive animals. Detection of viral RNA in tissue samples and excreta/secreta from mice suggest that differences may exist between naturally infected rodents with respect to viral shedding.

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Cited by 20 publications
(22 citation statements)
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“…Person-to-person transmission of ANDV has been reported (29,35,37,51), but the mechanism of person-to-person virus dissemination remains to be elucidated. As hantaviruses are shed in the urine of infected rodents (21,24,41), we speculated that this biological fluid would be a good starting point to document ANDV shedding in infected humans. Additionally, a recent epidemiological study supports this possibility (10).…”
Section: Resultsmentioning
confidence: 99%
“…Person-to-person transmission of ANDV has been reported (29,35,37,51), but the mechanism of person-to-person virus dissemination remains to be elucidated. As hantaviruses are shed in the urine of infected rodents (21,24,41), we speculated that this biological fluid would be a good starting point to document ANDV shedding in infected humans. Additionally, a recent epidemiological study supports this possibility (10).…”
Section: Resultsmentioning
confidence: 99%
“…This pattern of hantavirus shedding by the host has been adopted in a wide array of mathematical models describing hantavirus transmission among rodents and predicting the risk of human infections (Allen et al, 2009;Sauvage et al, 2007;Wolf, 2004). However, the current knowledge of hantavirus shedding patterns is, to a large extent, drawn from experimental infections of laboratory-reared animals, whereas only few studies have entailed the dynamics of shedding in naturally infected wild rodents (Bernshtein et al, 1999;Korva et al, 2009;McIntyre et al, 2005;Safronetz et al, 2005Safronetz et al, , 2008. In contrast to laboratory conditions with ad libitum food and water and thermoneutral temperature, rodents under the limited resources in their natural environment, often in harsh climatic conditions, are subjected to trade-offs between reproductive effort, longevity and immune response (Martin et al, 2008;Mills et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, several studies have shown fairly large proportions, i.e. 19-91 % (Boone et al, 1998(Boone et al, , 2002Kuenzi et al, 2005;McIntyre et al, 2005;Otteson et al, 1996;Rowe et al, 1995;Safronetz et al, 2005Safronetz et al, , 2006, of wild hantavirus antibody positive rodents to be RNA viraemic compared with what one might expect from the brief viraemia observed in laboratory studies (Easterbrook & Klein, 2008). For these reasons, we hypothesized that also hantavirus shedding via saliva, faeces and urine could last longer in naturally infected wild rodents than has been suggested by infection experiments in the laboratory.…”
Section: Introductionmentioning
confidence: 99%
“…Botten et al (2003) demonstrated that persistently infected deer mice had highly variable patterns of viral infection in regards to tissues involved and degree of viral replication. In a recent study (Safronetz et al, 2005), SNV RNA was amplified from tissues and excreta, including urine of some, but not all, naturally infected deer mice. These results, when taken together, suggest individual differences among naturally infected deer mice with respect to viral shedding.…”
Section: Introductionmentioning
confidence: 99%