A Preliminary Study of the Relationship between Some Circulating Pro- and Antioxidants and Erythrocyte COMT and Methemoglobin Reductase

Mj, Laires; Cp, Monteiro; Breitenfeld, Luiza; Neto, Ivo Vieira de Sousa; Franco, M. O.; Varela, Ana C.; Sergio, Julio; Felisberto, G. M.; Rola, E; C, Vaz; Bicho, M.; Manso, C

doi:10.1042/cs087s077a

Cited by 1 publication

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“…In insulin resistance and type 2 diabetes, Mg uptake into tissues is impaired so that plasma Mg may be within the normal range with intracellular Mg being decreased. Plasma Mg may be increased (Renrotte et al 1985;Porta et al 1994;Mocci et al 2001) or decreased (Cernak et al 2000;Laires et al 1993;Weissberg et al 1991;Whyte et al 1987) as part of stress reactions. Mild physical or psychological stress appears to increase plasma Mg, while prolonged severe or chronic stress decreases plasma Mg. Genetic differences may also occur at intracellular and extracellular Mg levels with increased stress sensitivity being associated with the lower Mg levels (Renrotte et al 1985(Renrotte et al , 1991(Renrotte et al , 1999.…”

Section: Magnesium Metabolismmentioning

confidence: 99%

Magnesium and Hearing

Cevette¹,

Vormann²,

Franz³

2003

J Am Acad Audiol

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The last several decades have revealed clinical and experimental data regarding the importance of magnesium (Mg) in hearing. Increased susceptibility to noise damage, ototoxicity, and auditory hyperexcitibility are linked to states of Mg deficiency. Evidence for these processes has come slowly and direct effects have remained elusive because plasma Mg levels do not always correlate with its deficiency. Despite the major progress in the understanding of cochlear mechanical and auditory nerve function, the neurochemical and pharmacologic role of Mg is not clear. The putative mechanism suggests that Mg deficiency may contribute to a metabolic cellular cascade of events. Mg deficiency leads to an increased permeability of the calcium channel in the hair cells with a consequent over influx of calcium, an increased release of glutamate via exocytosis, and over stimulation of NMDA receptors on the auditory nerve. This paper provides a current overview of relevant Mg metabolism and deficiency and its influence on hearing.

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Section: Magnesium Metabolismmentioning

confidence: 99%