A Preliminary Study to Treat Severe Endophthalmitis via a Foldable Capsular Vitreous Body with Sustained Levofloxacin Release in Rabbits

Wang, Ting; Huang, Xi; Gao, Qianying; Feng, Lianqiang; Xie, Zenghong; Jiang, Zhaoxin; Liu, Yaqin; Li, Yuye; Lin, Xiaofeng; Lin, Jintian

doi:10.1167/iovs.12-9695

Cited by 15 publications

(12 citation statements)

References 38 publications

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“…Beyond that, since there are numerous 300 nm tiny apertures designed on the surface of the capsule, the FCVB can act as an intravitreal drug delivery system (DDS), and release drugs following associated pharmacokinetics synchronously. Plus, FCVB will not change the chemical property of drugs [34,[36][37][38]. For instance, the implanted FCVB can sustainably and mechanically release dexamethasone sodium phosphate (the molecular mass = 516.41 Da) through the apertures in a time-dependent and a dose-dependent manner [22].…”

Section: Discussionmentioning

confidence: 99%

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Zhang

Tian²,

Zhang³

et al. 2019

BMC Ophthalmol

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Background: Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1-year follow-up. Methods: A retrospective analysis was conducted for 20 patients with severe ocular trauma or silicone oil (SO) dependent eyes underwent vitrectomy and FCVB implantation in a 1-year follow-up. All treated eyes were peformed clinical examinations involved the visual acuity (VA) examination, Goldmann applanation tonometer, noncontact specular microscopy, fundus photography, B-Scan examination and optical coherence tomography (OCT). The groups were compared with t-test and the McNemar-Bowker test. Results: In 1-year follow-up, 20 eyes were evaluated in the study. FCVB well supported the vitreous retina in all treated eyes, and 6 treated eyes achieved retinal reattachment 12 months after FCVB implantation. There were no significant differences in VA before and after FCVB implantation (P = 1.000). In addition, the postoperative IOP markedly elevated from the preoperative IOP of 12.90 ± 7.06 mmHg to 15.15 ± 3.36 mmHg (P = 0.000017). The intraocular pressure (IOP) of 10 eyes maintained at a normal level after surgeries. The other 10 eyes showed slightly lower IOP within the acceptable level. Though two patients developed keratopathy and ocular inflammation respectively, other treated eyes were symmetric with fellow eyes showing satisfactory appearance. Moreover, there was no SO emulsification or leakage happened in the observation. Conclusions: FCVB implantation was an effective and safe treatment in the eyes with severe retinal detachment.

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Section: Discussionmentioning

confidence: 99%

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Zhang

Tian²,

Zhang³

et al. 2019

BMC Ophthalmol

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“…Previous studies reported that an FCVB capsule with a 300-nm aperture in the capsule served as a drug delivery system for dexamethasone sodium phosphate, 20 levofloxacin, 26 , 27 5-fluorouracil, 28 voriconazole, and other potential drugs. In vivo and in vitro studies 29 reported that an FCVB sustainably and mechanically released 625 μg/mL of levofloxacin and effectively inhibited endophthalmitis in rabbits.…”

Section: Discussionmentioning

confidence: 99%

Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment

Lin

Wang

Jiang

et al. 2016

Trans. Vis. Sci. Tech.

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PurposeWe previously designed a novel foldable capsular vitreous body (FCVB) to treat severe retinal detachment and evaluated its performance in a 1-year follow up study. The purpose of this study was to determine the efficacy and safety of a silicone oil (SO)-filled FCVB in a 3-year follow-up.MethodsStandard three-port pars plana vitrectomy was performed, and the FCVB was triple folded and implanted in the vitreous cavity of three eyes. The SO then was injected into the capsule to support the retina. The eyes were examined using Goldmann applanation tonometry, fundus photography, optical coherence tomography (OCT), noncontact specular microscopy, and ultrasound biomicroscopy over a 3-year implantation period.ResultsAt the 3-year follow-up, retinal reattachment was achieved in all three cases, with steady intraocular pressure. The visual acuity showed slight fluctuations, and it was slightly increased compared to baseline. Optical coherence tomography revealed decreased retinal thickness and an altered retinal structure in the implanted eyes compared to the control eyes. No keratopathy, glaucoma, SO leakage, SO emulsification, or other apparent complications occurred during the observation period.ConclusionThe SO-filled FCVB was effective and safe as a vitreous substitute in three eyes over a 3-year observation period.Translational RelevanceSilicone oil emulsification is a severe complication after retinal detachment surgery. On the basis of animal experiments, we investigated a new strategy and product, the FCVB, to overcome this complication. In this pilot study, FCVB limited SO emulsification and migration. This study could lay the foundation for a further multicenter clinical trial.

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“…Foldable capsular vitreous body17, 18 independently developed by Zhongshan Ophthalmic Center reflects such an innovative awareness. Of course, whether it can be universally and clinically applicable and even replace silicone oil and long-acting gas depends on constant improvement and long-term clinical verification.

Postoperative endophthalmitis, particularly endophthalmitis after cataract surgery, has been well realized and can be successfully managed.

…”

Section: Comprehensive Development Of Medical Treatment For Eye Injurmentioning

confidence: 99%

Development of medical treatment for eye injuries in the mainland of China over the past decade

Wang

2016

Chinese Journal of Traumatology

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In the article, the development of medical treatment for eye injuries in the mainland of China was reviewed. According to the data provided in Eye Injury Vitrectomy Study (EIVS), 27% of 72 eyes with no light perception (NLP) gained recovery in term of antomy and visual function. Vitrectomy initiated at more than 4 weeks after open eye injury is an independent risk factor for developing PVR. Prognosis of anatomy and visual function of the injured eye with PVR is markedly worse than that without PVR. Serious injuries of ciliary body, choroid and retina are three key parts of the eye with NLP. The concept that the treatment of the eye injury gradually focus on the whole globe is embodied. The data from 13575 in patients with traumatic eyes in 14 hospitals revealed that the rate of immediate enucleation was remarkable reduced with comparison of 20 years ago.

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A Preliminary Study to Treat Severe Endophthalmitis via a Foldable Capsular Vitreous Body with Sustained Levofloxacin Release in Rabbits

Abstract: The FCVB could provide us with dual functions, combining a levofloxacin drug delivery system and a vitreous substitute, to treat endophthalmitis in rabbit eyes.

Cited by 15 publications

References 38 publications

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment

Development of medical treatment for eye injuries in the mainland of China over the past decade

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