A Preoperative Scoring System for Adnexal Mass in Children and Adolescents to Preserve Their Future Fertility

Depoers, Charlotte; Martin, Flore-Anne; Timoh, Krystel Nyangoh; Morçet, Jeff; Proisy, Maïa; Henno, Sébastien; Lavoué, Vincent; Arnaud, Alexis

doi:10.1016/j.jpag.2018.08.009

Cited by 26 publications

(11 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 11 , 30 These markers could be useful in differentiating between benign and malignant cysts, although their values are elevated in only 54% of the adnexal malignant neoplasms and in 6.5% of the benign lesions. 13 , 55 There are insufficient studies on the predictive value of CA 125 levels for malignant POCs. 1…”

Section: Resultsmentioning

confidence: 99%

Clinical, Imaging, Histological and Surgical Aspects Regarding Giant Paraovarian Cysts: A Systematic Review

Ștefanopol¹,

Baroiu²,

Neagu³

et al. 2022

TCRM

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Clinical, Imaging, Histological and Surgical Aspects Regarding Giant Paraovarian Cysts: A Systematic Review

Ștefanopol¹,

Baroiu²,

Neagu³

et al. 2022

TCRM

View full text Add to dashboard Cite

“…CA 125 N 35 U/mL CA 19-9 N 37 U/mL AFP N 10 ng/mL Quantitative beta-hCG N 2.3 mIU/mL LDH N 170 U/L CEA N 3 ng/mL Inhibin A N 80 pg/mL Inhibin B N 44 pg/mL for age 2-5 years; N 27 pg/mL for age 5-8; N 67 pg/mL for age [8][9][10][11]; N 120 pg/mL for age 11-14; and N 136 pg/mL for age 14-21. The rate of testing for tumor markers in this high-risk cohort varied considerably ( Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…Recently, efforts are being made to promote ovary-sparing surgery in the appropriate setting [5][6][7]. However, one of the challenges facing surgeons is how best to preoperatively risk stratify the patient who presents with an ovarian neoplasm [3,4,[8][9][10]. Elements of the patient's history, physical exam, imaging, and laboratory testing may be used to determine the best operative approach for patients with ovarian masses that are concerning for malignancy.…”

mentioning

confidence: 99%

Understanding the Value of Tumor Markers in Pediatric Ovarian Neoplasms

Lawrence

Fallat

Hewitt

et al. 2020

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Purpose: The purpose of this study was to determine the diagnostic accuracy of tumor markers for malignancy in girls with ovarian neoplasms. Methods: A retrospective review of girls 2-21 years who presented for surgical management of an ovarian neoplasm across 10 children's hospitals between 2010 and 2016 was performed. Patients who had at least one concerning feature on imaging and had tumor marker testing were included in the study. Sensitivity, specificity, and negative and positive predictive values (PPV) of tumor markers were calculated. Results: Our cohort included 401 patients; 22.4% had a malignancy. Testing for tumor markers was inconsistent. AFP had high specificity (98%) and low sensitivity (42%) with a PPV of 86%. The sensitivity, specificity, and PPV of beta-hCG was 44%, 76%, and 32%, respectively. LDH had high sensitivity (95%) and Inhibin A and Inhibin B had high specificity (97% and 92%, respectively). Conclusions: Tumor marker testing is helpful in preoperative risk stratification of ovarian neoplasms for malignancy. Given the variety of potential tumor types, no single marker provides enough reliability, and therefore a panel of tumor marker testing is recommended if there is concern for malignancy. Prospective studies may help further elucidate the predictive value of tumor markers in a pediatric ovarian neoplasm population. Type of Study: Retrospective Cohort Review. Level of Evidence: Level III.

show abstract

“…Most of the information about these two types of surgical management comes from small case series of single institutions; there is only one multicentric study about the comparison of laparoscopy and laparotomy, which was published by Ghezzi et al The study recruited 65 patients who underwent fertility-sparing and staging surgery by laparoscopy. They reported similar outcomes in terms of disease-free survival and overall survival, definitive results were not obtained with respect to the fertility rate, and more studies are necessary to clarify this point (14,15).…”

Section: Surgical Approachmentioning

confidence: 98%

Fertility-sparing treatment for epithelial ovarian cancer: a literature review

et al. 2020

View full text Add to dashboard Cite

Epithelial ovarian cancer is more common in postmenopausal women, with a mean age at diagnosis of 65 years; however, it has been documented that 3% to 17% of epithelial ovarian cancer cases are diagnosed in women younger than 40 years, with an overall survival of up to 90% when diagnosed in early-stage disease. The development of fertility-sparing approaches represents one of the most significant advances in the gynecologic oncology field. These approaches can have satisfactory outcomes on fertility with excellent oncological results in premenopausal women with early-stage epithelial ovarian cancer and the desire to preserve fertility. Because of the low occurrence of this specific population, randomized trials have not been performed. However, several retrospective series suggest that in certain cases, fertility-sparing surgery is safe, with low rates of recurrence and favorable reproductive outcomes in accordance to the new techniques in reproductive biology; therefore, fertility-sparing approaches must be discussed with young female patients with epithelial ovarian cancer or in patients that desire to preserve fertility or to maintain ovarian function and to improve quality of life in this particular group of individuals. In this review, we present the published evidence, including oncologic and reproductive results, as well as fertility-sparing surgical options, in the field in the last 10 years.

show abstract

A Preoperative Scoring System for Adnexal Mass in Children and Adolescents to Preserve Their Future Fertility

Cited by 26 publications

References 42 publications

Clinical, Imaging, Histological and Surgical Aspects Regarding Giant Paraovarian Cysts: A Systematic Review

Clinical, Imaging, Histological and Surgical Aspects Regarding Giant Paraovarian Cysts: A Systematic Review

Understanding the Value of Tumor Markers in Pediatric Ovarian Neoplasms

Fertility-sparing treatment for epithelial ovarian cancer: a literature review

Contact Info

Product

Resources

About