Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that targets organ systems like the renal, central, and cardiopulmonary systems. SLE is the number one leading cause of death among women due to the illness and its comorbidities. Lupus requires lifetime management and care. Physical activity is crucial for treating patients with lupus, as previous studies have shown improvements in fatigue, pain, and overall quality of life. However, there is still a lack of participation in physical activity among patients with lupus. Therefore, this study aims to discover the obstacles presented by living with lupus that affect individuals' self-efficacy for physical activity. Data collection was done through semi-structured one-on-one interviews with 6 young adult women with lupus. Findings revealed that all participants experienced shock, fear, and uncertainty from their diagnosis due to a lack of guidance and information about the disease. A lack of energy, pain and mental barriers refrained these participants from engaging in physical activity. However, their support system and their desire to manage their lupus healthily served as a facilitator to participate in physical activities.