A Pressure Chamber to Simulate the Microcirculation of Compartmental Syndromes

Seebode, Dorothea; Scheidt, Holger A.; Schmid‐Schönbein, H.

doi:10.1006/mvre.1994.1031

Cited by 4 publications

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“…To analyze the effects of the differing aggregation behavior on microcirculation in vivo, the microvascular bed of isolated rat mesentery (10) was perfused with moderately and strongly aggregating RBC solutions. The preparation of the rat mesentery has been described in detail elsewhere (11–17).…”

Section: Methodsmentioning

confidence: 99%

“…Friedman's hemodynamic model for AMD pathogenesis contributes to the hypothesis on the mechanism of action of rheopheresis for dry AMD (5,6). The decline of perfusion and microvessel function in the submacular choroidea, which is the supplying vascular bed of the macula region, is an important factor for the progressionof AMD (7–14). Additionally, impaired perfusion provokes pathological processes, such as local inflammation, immune reactions, and deposition of macromolecules in the retina, which cause further deterioration of perfusion (1,7).…”

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confidence: 99%

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Effects of Fibrinogen and α₂‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates

et al. 2008

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Methods of therapeutic apheresis, such as plasma exchange or rheopheresis eliminate moderately aggregating macromolecules like fibrinogen, as well as strongly aggregating substances like alpha2-macroglobulin from blood. In order to examine the specific effect of eliminating alpha2-macroglobulin as a highly aggregating macromolecule, this study aimed to analyze the different rheological properties of: (i) moderately aggregating red blood cells (RBCs; inducible by fibrinogen); and (ii) strongly aggregating RBCs (inducible by alpha2-macroglobulin). In vitro, RBC aggregate geometry was determined in the presence of strong and moderate aggregation inducing macromolecules. In vivo, flow behavior of RBC aggregates was analyzed by intravital microscopy. Using network scanning, the number of perfused and non-perfused microvessels was determined. In vitro, the higher adhesive forces of strongly aggregating RBCs led to both a higher packing density of single RBCs within aggregates, expressed as a significantly reduced thickness of individual RBCs, and greater deformation, expressed as a significantly diminished offset between RBCs and an increased curvature of RBCs at the ends of the aggregates. In vivo rheoscopy showed that only high aggregating RBCs persisted in the precapillary bed and led to the absence of RBCs in up to 40% of nutritive capillaries. These novel findings are of importance regarding recent developments in clinical hemorheology, specifically the clinical use of hemapheretic therapies for diseases in which impaired microcirculation plays a role in either their development or progression, such as age-related macular degeneration and complications of diabetes mellitus. Our data support that procedures reducing the concentration of alpha2-macroglobulin in blood by extracorporeal elimination might provide a more efficient improvement of overall blood fluidity in microcirculatory beds.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of Fibrinogen and α₂‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates

et al. 2008

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Early diagnosis of tibial compartment syndrome: Continuous pressure measurement or not?

Giannoudis

Tzioupis

Pape

2009

Injury

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The impact of both-bone forearm fractures on acute compartment syndrome: An analysis of predisposing factors

Yang¹,

Wang²,

Long³

et al. 2023

Injury

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A Pressure Chamber to Simulate the Microcirculation of Compartmental Syndromes

Cited by 4 publications

References 0 publications

Effects of Fibrinogen and α₂‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates

Effects of Fibrinogen and α₂‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates

Early diagnosis of tibial compartment syndrome: Continuous pressure measurement or not?

The impact of both-bone forearm fractures on acute compartment syndrome: An analysis of predisposing factors

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A Pressure Chamber to Simulate the Microcirculation of Compartmental Syndromes

Cited by 4 publications

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Effects of Fibrinogen and α2‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates

Effects of Fibrinogen and α2‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates

Early diagnosis of tibial compartment syndrome: Continuous pressure measurement or not?

The impact of both-bone forearm fractures on acute compartment syndrome: An analysis of predisposing factors

Contact Info

Product

Resources

About

Effects of Fibrinogen and α₂‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates

Effects of Fibrinogen and α₂‐Macroglobulin and Their Apheretic Elimination on General Blood Rheology and Rheological Characteristics of Red Blood Cell Aggregates