A Presumptive Human XXY/XX Mosaic

Ford, C. E.; Polani, P. E.; Briggs, Jack; Bishop, P. M. F.

doi:10.1038/1831030a0

Cited by 182 publications

(38 citation statements)

References 8 publications

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“…If this is followed by mitotic non-disjunction, sex chromosome mosaics will arise and Ford (1959a, c) has in fact explained the origin of Klinefelter and Turner mosaics in this way.…”

Section: Case Notementioning

confidence: 99%

“…In this case, as in that of Ford's (1959a, c), observation has been confined to the bone marrow where ideal conditions exist for the identification of mosaicism. The occurrence of mosaicism in this tissue implies that non-disjunction must have occurred before the functional marrow tissue was produced.…”

Section: Case Notementioning

confidence: 99%

“…Of particular interest is the suggestion by Ford (1959a, c) that possible mosaicism for the sex chromosomes may occur in both Turner's and Klinefelter's syndromes. In the former condition three cases of presumptive XO/XX mosaics were described and in the latter, one case of a presumptive XXY/XX mosaic.…”

Section: Introductionmentioning

confidence: 99%

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Sex chromosome mosaicism in man

Hayward

1960

Heredity

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“…If this is followed by mitotic non-disjunction, sex chromosome mosaics will arise and Ford (1959a, c) has in fact explained the origin of Klinefelter and Turner mosaics in this way.…”

Section: Case Notementioning

confidence: 99%

Section: Case Notementioning

confidence: 99%

See 1 more Smart Citation

Sex chromosome mosaicism in man

Hayward

1960

Heredity

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“…He has also contested the theoretical basis of their argument that an increase in the number of males might have been expected on the basis of the physiological inertness of the human Y chromosome, and hence its lack of susceptibility to a dominant lethal type of injury. Recent evidence would argue against such inertness of the Y (Jacobs and Strong, '959; Ford, Polani, Briggs and Bishop, 1959). Some explanation of the variations in the response of different species may be found in the relative activities and sizes of the sex chromosomes.…”

Section: Discussionmentioning

confidence: 99%

The effect of gamma irradiation on the sex ratio of Melandrium species

Davies

Wall

1961

Heredity

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THE data available on the effect of ionising radiations on sex ratios in higher organisms are conflicting. Early work with Drosophila showed that the sex ratio tended to change in favour of males (reviewed by Catcheside and Lea, 1945), and Schull and Neel (i) concluded that there was a significant increase in the number of males in the progenies of human males exposed to the Japanese explosions.However, with mice exposed to doses of up to 1000 rads in both the pre-and post-sterile periods there was no significant change in the sex ratio of their progenies (Hertwig, 1938; Russell, Kohn, 1960). In the present experiment we have studied the effect of gamma radiation on the sex ratio of progenies of Melandrium species. These are dioecious species having an X-Y sex mechanism, a heterogametic male sex and heteromorphic sex chromosomes, the Y being longer than the X and having a definite male influence. MATERIALS AND METHODSThree populations of Mdandrium album (La 6, 8 and g) and one of M. rubrum (La 3) were used, one male plant and two females being chosen at random from each population. Two flowers on each female plant were pollinated with pollen from the selected male parent of that population. Mature pollen was exposed to one of the following doses of y-rays, at a rate of rads per minute-25, 100, 400, x6oo and 6400 rads, and used immediately afterwards for pollination of the female flowers. Control pollinations were also made in all instances. Care was taken to ensure that all pollinations were as uniform as possible-all being massive pollinations of the base of the styles. This was important in view of the known differential growth rates of X and Y bearing pollen tubes. All progenies were space planted in boxes maintained initially in the greenhouse and later outdoors. RESULTSDetails of percentage germination and percentage females are given in tables 1-4. No correlation existed between these two percentages (t10 = 1.615; P = 02 to o.i). The populations differed in terms of the percentage females and differences also occurred between genotypes within populations (table 5). In most instances there was a tendency for an increase in the proportion of females with increasing dose. This increase was not linear-a proportionally greater one occurring at lower doses, followed in several instances by a drop and a further later increase (see table 5 " within irradiated "). Control progenies differed '3'

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“…Since the first report of Ford et al (1959) regarding 46,XX/47,XXY mosaicism, a number of cases have been recorded in man (cf. Makino 1975).…”

mentioning

confidence: 99%