A Pretreatment Method for Analysing Albendazole by HPLC in Plant Material

Marciocha, Dorota; Kalka, Joanna; Turek–Szytow, Jolanta; Surmacz-Górska, Joanna

doi:10.1007/s11270-013-1646-6

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…The samples were analysed by HPLC to quantify the drug using the standard calibration curve. [17]. The concentration of ABZ in liposomes was calculated using a standard calibration curve.…”

Section: Release Profilementioning

confidence: 99%

Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing

Maqbool

Moyle

Tan

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Supercritical fluid (SCF) technology offers a potential green alternative to organic solvent-based methods for drug formulation. Albendazole (ABZ) has promising anticancer activity when formulated to increase its cellular uptake. Herein, a static volume method was used to determine the solubility of ABZ in supercritical carbon dioxide (scCO 2) for the future development of such ABZ formulations. The solubility of ABZ in scCO 2 (250 bar, 37 C) was approximately 12 mg/100 mL. The extent of dissolution was measured at various time points to determine when saturation solubility occurred, which was demonstrated from 9 h. In order to determine if scCO 2 processing induced ABZ polymorphism, DSC/ TGA, FTIR and XRD were used, which demonstrated no change in its solid state. Following this, ABZ loaded liposomes were manufactured using SCF technology. The liposomes diameter was 167.2 ± 5.3 nm as determined by Zetasizer, and confirmed by cryo-transmission electron microscopy. In conclusion, scCO 2 was used successfully to solubilize ABZ, and to manufacture liposomes of nano-sized range. This study provides insight into use of green technology for future ABZ liposomal formulation without the need for organic solvents.

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“…The samples were analysed by HPLC to quantify the drug using the standard calibration curve. [17]. The concentration of ABZ in liposomes was calculated using a standard calibration curve.…”

Section: Release Profilementioning

confidence: 99%

Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing

Maqbool

Moyle

Tan

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…At typical detected environmental concentrations, DCF does not exhibit toxic effects towards living organisms, albeit chronic exposure may lead to severe effects (Felis et al, 2005;Marciocha et al, 2013;Acuña et al, 2015;Lonappan et al, 2016;Desbiolles et al, 2018;Klopčič et al, 2018). Diclofenac due to frequent detection in the environment enters the food chain and accumulates in aquatic organisms, mainly fish.…”

Section: Introductionmentioning

confidence: 99%

Archives of Environmental Protection

Matejczyk¹,

Ofman²,

Dąbrowska³

et al. 2020

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In environmental matrices there are mixtures of parent drug and its metabolites. The majority of research is focused on the biological activity and toxic effect of diclofenac (DCF), there is little research on the biological activity of DCF metabolites and their mixtures. The study focused on the assessment of the biological impact of DCF, its metabolites 4'-hydroxydiclofenac (4'-OHDCF) and 5-hydroxydiclofenac (5-OHDCF) and their mixtures on E. coli strains. The biological effects of tested chemicals were evaluated using the following: E. coli K-12 cells viability assay, the inhibition of bacteria culture growth, ROS (reactive oxygene species) generation and glutathione (GSH) content estimation. Moreover, we examined the influence of the mixture of DCF with caffeic acid (CA) on E. coli cells viability. Our results showed the strongest impact of the mixtures of DCF with 4'-OHDCF and 5-OHDCF on E. coli SM biosensor strains in comparison to parent chemicals. Similar results were obtained in viability test, where we noticed the highest reduction in E. coli cell viability after bacteria incubation with the mixtures of DCF with 4'-OHDCF and 5-OHDCF. Similarly, these mixtures strongly inhibited the growth of E. coli culture. We also found synergistic effect of caffeic acid in combination with DCF on E. coli cells viability. After bacteria treatment with the mixture of DCF and its metabolites we also noted the strongest amount of ROS generation and GSH depletion in E. coli culture. It suggests that oxidative stress is the most important mechanism underlying the activity of DCF and its metabolites.

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“…Drugs infiltrating into the soil with organic fertilizers influence the quality of both the soil and the crop (Davis et al 2006;Oliver and Gregory 2015). The negative environmental impact is mainly due to organisms' ability to immobilize and accumulate medicines in their tissues (Boxall et al 2003;Kumar et al 2005;Marciocha et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Peroxide impact on the fate of veterinary drugs in fertilizers

et al. 2019

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The presence of veterinary medicines in organic manure causes soil contamination which contributes to increasing resistance of indigenous microflora to drugs and results in greater susceptibility of people to allergies. The main aim of the study was to assess the efficiency of inorganic peroxide mixtures (PM) with calcium peroxide content (CaO 2) in the stabilization process of manure contaminated with antiparasitic agents: albendazole (ALB) and levamisole (LEV). As a solid, CaO 2 is relatively stable against decomposition. In contact with water, however, it hydrolyzes with release of oxygen. The hydrolyzation of CaO 2 proceeds very slowly in soil, which guarantees the constant release of hydrogen peroxide that subsequently becomes the source of free radicals (chemical oxidation) and oxygen (aerobic conditions for the microbes). It may contribute to continuous elimination of drugs from manure. The study has demonstrated that there were significant differences in ALB and LEV conversion stimulated by the PM addition. PM supplementation increased the drug availability (on average 15% and 25% increase in the initial concentration for ALB and for LEV, respectively), thereby increasing the initial rate of reaction. Elimination of ALB and LEV from the manure sorption complex is followed by Ca 2+ saturation. The initial degradation rate was affected by PM for both drugs, but the mechanisms of decomposition have been modified only for ALB. The loss of ALB in the peroxide supplemented samples was 92%, and in the samples, without the PM, it did not exceed 61%. Loss of LEV was over 90% irrespective of PM supplementation.

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A Pretreatment Method for Analysing Albendazole by HPLC in Plant Material

Cited by 6 publications

References 15 publications

Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing

Preparation of albendazole-loaded liposomes by supercritical carbon dioxide processing

Archives of Environmental Protection

Peroxide impact on the fate of veterinary drugs in fertilizers

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