A prevalence study of IgG4-related ophthalmic disease in Japan

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doi:10.1007/s10384-013-0266-4

Cited by 66 publications

(20 citation statements)

References 38 publications

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“…[6,16,17] As previously suggested, sIgG4 elevation was preferentially associated with bilateral forms, and was associated with extra-orbital and systemic manifestations of IgG4-RD. [3] Under treatment, sIgG4 normalized in most evaluable patients (5/6 evaluable patients treated for IgG4-ROD) and correlated with clinical and radiological responses of the disease.…”

Section: Discussionmentioning

confidence: 86%

“…[6,14,16,17] IgG4-ROD was first identified thanks to the reporting of patients with orbital manifestations concomitant to other IgG4-RD manifestations and to the retrospective search of IgG4-RD pathological characteristics in pathological specimen of inflammatory orbital diseases. The frequency of IgG4-ROD ranges 4% to 34% of IgG4-RD patients according to the largest case series published to date.…”

Section: Discussionmentioning

confidence: 99%

“…[3,4,13] Retrospective analysis of pathological specimen from benign lymphoproliferative disorders and orbital inflammation have reported specific characteristics of IgG4-RD in up to 40% of cases. [14,15] Such discrepancies between studies in the rates of IgG4-R0D can, at least partly, be explained by the differences of disease criteria retained for tissue IgG4 + plasma cells infiltrates (i.e., either > 10/high power field (HPF), [7] > 30/HPF [16] or > 50–100/HPF [11] with an IgG4+/IgG+ ratio >40%). One hundred seventy-two pooled cases of IgG4-ROD from case-series or case reports have been recently analyzed in a review.…”

Section: Introductionmentioning

confidence: 99%

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Ophthalmic manifestations in IgG4-related disease

et al. 2017

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ophthalmic manifestations in IgG4-related disease

et al. 2017

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“…Recent studies have confirmed that conditions previously diagnosed as Mikulicz disease as well as various types of lymphoplasmacytic infiltrative disorders are consistent with a diagnosis of IgG4-related disease [1,2]. After the establishment of comprehensive diagnostic criteria for IgG4-related disease in 2012 [3], the diagnostic criteria for IgG4-related ophthalmic disease (IgG4-ROD) have recently been reported, based on both clinical and histopathologic features of ocular lesions [4].…”

Section: Introductionmentioning

confidence: 83%

Immunoglobulin G4-Related Ophthalmic Disease Involving the Sclera Misdiagnosed as Intraocular Tumor: Report of One Case

Gotô

Ueda

2016

Ocul Oncol Pathol

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Aims: Immunoglobulin G4 (IgG4)-related disease is known to have diverse clinical manifestations. We report a case of IgG4-related ophthalmic disease misdiagnosed as intraocular tumor. Methods: Case report. Results: A 41-year-old man was referred to our department with a diagnosis of intraocular tumor, presumably choroidal melanoma. Although MR imaging was compatible with choroidal melanoma, he had been observed periodically without treatment because fundus findings were not typical of melanoma and visual function was preserved. He was again referred to us 15 years later due to increased tumor size and visual field disturbance. Transscleral biopsy of the intraocular tumor was attempted to make a histopathological diagnosis. During the biopsy procedure, thick placoid tissue adhering to the sclera was found at a location consistent with the site of the elevated intraocular lesion. Histopathological examination of this extraocular material revealed proliferation of dense fibrous tissue with follicular proliferation of lymphocytes and plasmacytes. The plasmacytes were diffusely positive for IgG and IgG4. Serum IgG4 level was slightly elevated and no extraocular lesion was detected. Despite administration of systemic corticosteroids after biopsy, the intraocular mass was not reduced. Visual acuity of 20/20 has been maintained as of the last follow-up. Conclusion: IgG4-related disease should be included in the differential diagnosis of intraocular elevated lesion.

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“…In Japan, MALT lymphoma is the most frequent primary malignancy of the ocular adnexa region, whereas IgG4-related ophthalmic disease (IgG4-ROD) and reactive lymphoid hyperplasia (RLH) are the most common benign LPDs of the ocular adnexa45. The etiologies of most LPDs of the ocular adnexa have been widely investigated, but several other disorders including IgG4-ROD require further study.…”

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confidence: 99%

Comprehensive polymerase chain reaction assay for detection of pathogenic DNA in lymphoproliferative disorders of the ocular adnexa

Usui

Rao

Takase

et al. 2016

Sci Rep

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Infectious agents have been identified as a major cause of specific types of human cancers worldwide. Several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. This study aimed to conduct an exhaustive search for pathogenic DNA in lymphoproliferative disorders (LPD) of the ocular adnexa in a total of 70 patients who were diagnosed with LPD of the ocular adnexa between 2008 and 2013. Specimens were screened for bacterial, viral, fungal, and parasitic DNA by multiplex polymerase chain reaction (PCR) and quantitative real-time PCR. Among cases of conjunctival mucosa-associated lymphoid tissue lymphoma, human herpes virus (HHV)-6, HHV-7, chlamydia, Epstein-Barr virus (EBV) and bacterial 16S ribosomal DNA were detected. In cases of IgG4-related ocular disease, similar pathogens were detected but in a larger number of patients. Our PCR assays detected DNAs of various infectious agents in tumor specimens, especially HHV6, HHV7, and EBV, with different positive rates in various types of LPD. Chronic inflammatory stimulation or activation of oncogenes from these infectious agents might be involved in the pathogenesis of LPD of the ocular adnexa.

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A prevalence study of IgG4-related ophthalmic disease in Japan

Abstract: Nearly a quarter of orbital lymphoproliferative disorders in Japan are related to IgG4.

Cited by 66 publications

References 38 publications

Ophthalmic manifestations in IgG4-related disease

Ophthalmic manifestations in IgG4-related disease

Immunoglobulin G4-Related Ophthalmic Disease Involving the Sclera Misdiagnosed as Intraocular Tumor: Report of One Case

Comprehensive polymerase chain reaction assay for detection of pathogenic DNA in lymphoproliferative disorders of the ocular adnexa

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