A prevalence study of ocular manifestations in HIV positive patients on highly active anti-retroviral therapy

Hothi, Hemal S.; Gohil, Neepa R.; Parekh, Nilesh V.; Patel, Sagar S.

doi:10.18203/2394-6040.ijcmph20192831

Cited by 4 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adnexal involvement, anterior segment involvement, posterior segment involvement, neuro-ophthalmic abnormalities, and orbital involvement all occurred in 20%, 28%, 33%, and 4% of these cases, respectively. In total, 51% of patients had CD4+ T cell counts under 200 cells/L, and 76% were in the WHO clinical stages 2 and 3 [ 24 ]. We observed that infectious eye diseases were more frequent in cases with CD4 levels of <200/mL and 201–499/mL.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmological Manifestations in People with HIV from Northeastern Romania

Cobaschi,

Loghin,

Dorobăț

et al. 2023

Medicina

View full text Add to dashboard Cite

Background and Objectives: Although ocular disorders can occasionally impact people with HIV over the course of their illness, HIV/AIDS is unmistakably a multisystem disorder. A physician can rule out a wide range of ophthalmic problems with the assistance of an ophthalmologist, from adnexal disorders to posterior segment diseases, including those affecting the optic tract and optic nerve. Materials and Methods: Based on patient medical data from the “St. Parascheva” Clinical Hospital of Infectious Diseases in Iasi, we carried out a retrospective clinical investigation on patients with HIV/AIDS and ophthalmological conditions who were hospitalized in northeastern Romania. We seek to draw attention to the characteristics and ophthalmological comorbidities of HIV/AIDS patients. The studied period was between 1 January 1991 and 31 December 2022. Results: There were a total of 38 recorded cases of ophthalmological manifestations in the HIV-infected patients. The research group’s average age was 37.31 years old (standard deviation 9.5693917). Males were primarily impacted, having lower total CD4+ T-lymphocyte levels based on sex and CD4+ T-lymphocyte levels overall. The HIV viral load was 999 268.13 copies/mL on average (standard deviation 1,653,722.9). Of all the patients, we found out that 17 had congenital eye diseases (44.73%) and the others (21, 55.26%) developed ophthalmological diseases. CMV Retinitis was found most frequently, in eight patients (21.05%), followed by Myopia in seven patients (18.42%). Conclusions: The key to the management of HIV-positive patients is a multidisciplinary approach and access to antiretroviral therapy. Anyone who is HIV-positive and experiences ocular symptoms at any time should be directed to seek professional ophthalmologic treatment as soon as feasible. A therapeutic holdup could result in irreversible vision loss. Long-term coordination is required to combat this disease, improving communication between the ophthalmology and infectious disease fields.

show abstract

Section: Discussionmentioning

confidence: 99%

Ophthalmological Manifestations in People with HIV from Northeastern Romania

Cobaschi,

Loghin,

Dorobăț

et al. 2023

Medicina

View full text Add to dashboard Cite

show abstract

Prevalence of ocular manifestations in HIV patients

Ananthan,

Kumar,

Rayar

et al. 2024

IJCEO

View full text Add to dashboard Cite

: To study the prevalence of ocular manifestations in the HIV-positive individuals and find out the different types of ocular manifestations in HIV patients based on their CD4 count levels. This is a cross-sectional observational study with a sample size of 70 which will be conducted in department of Ophthalmology at Trichy SRM Medical College Hospital & Research Centre. This study includes all HIV positive patients irrespective of their age group, gender. A total of 70 cases were included in this study. HIV induced ocular manifestations were present in 33 out of 70 patients which has accounted for 47% in our study. Most of the patients with HIV were in the age group ranging between 20 years to 70 years. Most commonly seen ocular manifestations were anterior segment manifestations accounting for 33.33% and then adnexal manifestations (27%), posterior segment manifestations (24%) and the neuro-ophthalmic manifestations (15.15%). Ocular manifestations with highest prevalence were seen to be present in population with CD4 ranging between 250-300 cells/mm. Of these anterior segment manifestations were common.: In our study, anterior segment manifestations were more commonly seen than posterior segment manifestations. Dry Eye disorder and HIV Retinopathy are the most commonly seen manifestations. Early screening of HIV positive individual should be done for the ocular manifestations at time of diagnosis.

show abstract

Vitreoretinal manifestations of human immunodeficiency virus infection and acquired immunodeficiency syndrome in patients attending an antiretroviral therapy clinic in Nigeria

Babalola

Oluleye

Ashaye

2022

Journal of Clinical Sciences

View full text Add to dashboard Cite

Background: The human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a multi-systemic disease with known manifestations involving all ocular structures from the orbit and ocular adnexa, anterior segment to the retina and vitreous. Some of these manifestations including cytomegalovirus (CMV) retinitis and HIV retinopathy are HIV/AIDS-defining illnesses. The aim of this study is to determine the vitreoretinal manifestations in patients with HIV/AIDS attending an antiretroviral therapy clinic in Nigeria. Methods: This was a prospective, cross-sectional study of consenting, confirmed HIV/AIDS patients attending an antiretroviral therapy clinic in Nigeria. All willing, consecutive patients who gave an informed consent were recruited. Sociodemographic data and clinical information were collected with the use of a structured interviewer–administered questionnaire. Best-corrected visual acuity was recorded. Anterior segment and ocular adnexa examination was performed with a pen torch. Detailed anterior and posterior segment examination was performed with slit lamp biomicroscopy with Volks +78 diopter lens and binocular indirect ophthalmoscopy. The data were analyzed with SPSS (statistical package for social sciences) version 16. Ethical approval was obtained from the institutional ethics committee. Results: Three hundred and eighteen patients were studied of which 85 (26.7%) had disorders affecting the retina and vitreous. The female-to-male ratio was 2:1. More than a third of patients (38.7%) were in the 40–49 years of age group and the mean age was 47.2 years. The most common vitreoretinal lesion was presumed ocular toxoplasmosis present in 9.7% of all respondents. This was closely followed by HIV retinopathy in 3.5%, ocular tuberculosis in 1.8%, and CMV retinitis in 1.6% respondents. Two hundred and seventy-seven (87.1%) respondents were on highly active antiretroviral therapy and 41 (12.9%) were not on treatment. Conclusion: A high prevalence of ocular conditions especially those affecting the retina and vitreous exists in patients with HIV/AIDS attending the antiretroviral therapy clinic in a tertiary hospital in Nigeria. Regular eye examinations are recommended for these patients to prevent potentially visual debilitating disorders.

show abstract

A prevalence study of ocular manifestations in HIV positive patients on highly active anti-retroviral therapy

Cited by 4 publications

References 7 publications

Ophthalmological Manifestations in People with HIV from Northeastern Romania

Ophthalmological Manifestations in People with HIV from Northeastern Romania

Prevalence of ocular manifestations in HIV patients

Vitreoretinal manifestations of human immunodeficiency virus infection and acquired immunodeficiency syndrome in patients attending an antiretroviral therapy clinic in Nigeria

Contact Info

Product

Resources

About